Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCε/mK ATP pathway in rats

Phytomedicine

Volumn 18, Issue 11, 2011, Pages 916-925

  Chiu, Po Yee ^a   Wong, Sze Man ^a   Leung, Hoi Yan ^a   Leong, Pou Kuan ^a   Chen, Na ^a   Zhou, Limin ^b   Zuo, Zhong ^b   Lam, Philip Y ^a   Ko, Kam Ming ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Danshen Gegen; Ischemia; Myocardium; Protein kinase C; Redox; Reperfusion; Root of Salvia miltiorrhiza Pueraria Lobata

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ALPHA TOCOPHEROL; CALCIUM; CYTOCHROME C; DANSHEN GEGEN DECOCTION; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN KINASE C EPSILON; PUERARIA EXTRACT; SALVIA MILTIORRHIZA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFICACY; EX VIVO STUDY; FEMALE; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISCHEMIC PRECONDITIONING; MEMBRANE STRUCTURE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROPHYLAXIS; RAT; REPERFUSION INJURY; TREATMENT DURATION;

ALPHA-TOCOPHEROL; ANIMALS; CARDIOTONIC AGENTS; CYTOCHROMES C; DRUGS, CHINESE HERBAL; FEMALE; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATION-REDUCTION; PHENANTHROLINES; PLANT ROOTS; POTASSIUM CHANNELS; PROTEIN KINASE C-EPSILON; PUERARIA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SALVIA MILTIORRHIZA;

LOBATA; RATTUS; SALVIA; SALVIA MILTIORRHIZA;

EID: 80051871008     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.03.006     Document Type: Article

References (53)

1. J.D. Adams, R. Wang, J. Yang, and E.J. Lien Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions Chinese Med. 1 2006 3
2. J.S. Armstrong, and D.P. Jones Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells FASEB J. 16 2002 1263 1265
3. S.V. Bannur, S.V. Kulgod, S.S. Metkar, S.K. Mahajan, and J.K. Sainis Protein determination by ponceau S using digital color image analysis of protein spots on nitrocellulose membranes Anal. Biochem. 267 1999 382 389 (Pubitemid 29095887)
4. N. Baudry, E. Laemmel, and E. Vicaut In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice: involvement of xanthine oxidase and mitochondria Am. J. Physiol. Heart Circ. Physiol. 294 2008 H821 H828
5. P.S. Brookes, Y. Yoon, J.L. Robotham, M.W. Anders, and S.S. Sheu Calcium, ATP, and ROS: a mitochondrial love-hate triangle Am. J. Physiol. Cell Physiol. 287 2004 C817 C833
6. Q. Chang, L. Sun, R.H. Zhao, M.S. Chow, and Z. Zuo Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high-performance liquid chromatography Phytochem. Anal. 19 2008 368 375
7. P.Y. Chiu, and K.M. Ko Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats Mol. Cell. Biochem. 266 2004 139 144 (Pubitemid 39562314)
8. P.Y. Chiu, S.M. Wong, H.Y. Leung, P.K. Leong, N. Chen, L. Zhou, Z. Zuo, P.Y. Lam, and K.M. Ko Long-term treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCε/mKATP pathway in rats Rejuven Res. 2010 10.1089/rej.2010.1094
9. A.D. Costa, and K.D. Garlid Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT Am. J. Physiol. Heart Circ. Physiol. 295 2008 H874 H882
10. A.D. Costa, and K.D. Garlid MitoKATP activity in healthy and ischemic hearts J. Bioenerg. Biomembr. 41 2009 123 126
11. M. Degli Esposti Measuring mitochondrial reactive oxygen species Methods (San Diego, CA) 26 2002 335 340 (Pubitemid 34971573)
12. E.C. Dempsey, A.C. Newton, D. Mochly-Rosen, A.P. Fields, M.E. Reyland, P.A. Insel, and R.O. Messing Protein kinase C isozymes and the regulation of diverse cell responses Am. J. Physiol. Lung Cell. Mol. Physiol. 279 2000 L429 L438
13. H. Fauvel, P. Marchetti, G. Obert, O. Joulain, C. Chopin, P. Formstecher, and R. Neviere Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats Am. J. Respir. Crit. Care Med. 165 2002 449 455 (Pubitemid 34165466)
14. P. Ferdinandy, R. Schulz, and G.F. Baxter Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning Pharmacol. Rev. 59 2007 418 458
15. Q. Gao, H.Y. Pan, S. Qiu, Y. Lu, I.C. Bruce, J.H. Luo, and Q. Xia Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart Life Sci. 79 2006 217 224 (Pubitemid 43782549)
16. Q. Gao, B. Yang, Z.G. Ye, J. Wang, I.C. Bruce, and Q. Xia Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin Eur. J. Pharmacol. 574 2007 179 184 (Pubitemid 47575526)
17. K.D. Garlid, A.D. Costa, C.L. Quinlan, S.V. Pierre, and P. Dos Santos Cardioprotective signaling to mitochondria J. Mol. Cell. Cardiol. 46 2009 858 866
18. F.J. Giordano Oxygen, oxidative stress, hypoxia, and heart failure J. Clin. Invest. 115 2005 500 508 (Pubitemid 40322219)
19. O.W. Griffith Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Anal. Biochem. 106 1980 207 212 (Pubitemid 11246585)
20. T.E. Gunter, L. Buntinas, G. Sparagna, R. Eliseev, and K. Gunter Mitochondrial calcium transport: mechanisms and functions Cell Calcium 28 2000 285 296 (Pubitemid 32050824)
21. A.P. Halestrap, G.P. McStay, and S.J. Clarke The permeability transition pore complex: another view Biochimie 84 2002 153 166
22. D. Haouzi, I. Cohen, H.L. Vieira, D. Poncet, P. Boya, M. Castedo, N. Vadrot, A.S. Belzacq, D. Fau, C. Brenner, G. Feldmann, and G. Kroemer Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo Apoptosis 7 2002 395 405
23. D.J. Hausenloy, and D.M. Yellon New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway Cardiovasc. Res. 61 2004 448 460 (Pubitemid 38210151)
24. H. He, M. Shi, X. Yang, X. Zeng, L. Wu, and L. Li Comparison of cardioprotective effects using salvianolic acid B and benazepril for the treatment of chronic myocardial infarction in rats Naunyn-Schmiedeberg's Arch. Pharmacol. 378 2008 311 322
25. C. Hidalgo, P. Aracena, G. Sanchez, and P. Donoso Redox regulation of calcium release in skeletal and cardiac muscle Biol. Res. 35 2002 183 193 (Pubitemid 35189791)
26. X. Ji, B.K. Tan, Y.C. Zhu, W. Linz, and Y.Z. Zhu Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats Life Sci. 73 2003 1413 1426 (Pubitemid 36794583)
27. M.T. Jiang, Y. Nakae, M. Ljubkovic, W.M. Kwok, D.F. Stowe, and Z.J. Bosnjak Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers Anesth. Analg. 105 2007 926 932 table of contents (Pubitemid 47479302)
28. X. Jiang, and X. Wang Cytochrome C-mediated apoptosis Annu. Rev. Biochem. 73 2004 87 106 (Pubitemid 39050364)
29. A.N. Kavazis, J.M. McClung, D.A. Hood, and S.K. Powers Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli Am. J. Physiol. Heart Circ. Physiol. 294 2008 H928 H935
30. J.S. Kim, L. He, and J.J. Lemasters Mitochondrial permeability transition: a common pathway to necrosis and apoptosis Biochem. Biophys. Res. Commun. 304 2003 463 470 (Pubitemid 36506518)
31. J.W. Kim, Y.C. Jin, Y.M. Kim, S. Rhie, H.J. Kim, H.G. Seo, J.H. Lee, Y.L. Ha, and K.C. Chang Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kappaB activation Life Sci. 84 2009 227 234
32. K.M. Ko, and H.Y. Yiu Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts Mol. Cell. Biochem. 220 2001 141 147
33. G. Kroemer, and J.C. Reed Mitochondrial control of cell death Nat. Med. 6 2000 513 519 (Pubitemid 30305900)
34. Y.E. Kushnareva, and P.M. Sokolove Prooxidants open both the mitochondrial permeability transition pore and a low-conductance channel in the inner mitochondrial membrane Arch. Biochem. Biophys. 376 2000 377 388 (Pubitemid 30210887)
35. L. Lacerda, S. Somers, L.H. Opie, and S. Lecour Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway Cardiovasc. Res. 84 2009 201 208
36. F.F. Lam, S.Y. Deng, E.S. Ng, J.H. Yeung, Y.W. Kwan, C.B. Lau, J.C. Koon, L. Zhou, Z. Zuo, P.C. Leung, and K.P. Fung Mechanisms of the relaxant effect of a Danshen and Gegen formulation on rat isolated cerebral basilar artery J. Ethnopharmacol. 132 2010 186 192
37. C. Lu, and J.S. Armstrong Role of calcium and cyclophilin D in the regulation of mitochondrial permeabilization induced by glutathione depletion Biochem. Biophys. Res. Commun. 363 2007 572 577
38. G.P. McStay, S.J. Clarke, and A.P. Halestrap Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore Biochem. J. 367 2002 541 548 (Pubitemid 35216831)
39. A. Meister, and M.E. Anderson Glutathione Annu. Rev. Biochem. 52 1983 711 760 (Pubitemid 13030692)
40. M.A. Menze, K. Hutchinson, S.M. Laborde, and S.C. Hand Mitochondrial permeability transition in the crustacean Artemia franciscana: absence of a calcium-regulated pore in the face of profound calcium storage Am. J. Physiol. 289 2005 R68 R76
41. A.L. Moens, M.J. Claeys, J.P. Timmermans, and C.J. Vrints Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process Int. J. Cardiol. 100 2005 179 190
42. S. Numazawa, M. Ishikawa, A. Yoshida, S. Tanaka, and T. Yoshida Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress Am. J. Physiol. Cell Physiol. 285 2003 C334 C342
43. Y. Ohnuma, T. Miura, T. Miki, M. Tanno, A. Kuno, A. Tsuchida, and K. Shimamoto Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning Am. J. Physiol. Heart Circ. Physiol. 283 2002 H440 H447
44. M. Ovize, G.F. Baxter, F. Di Lisa, P. Ferdinandy, D. Garcia-Dorado, D.J. Hausenloy, G. Heusch, J. Vinten-Johansen, D.M. Yellon, and R. Schulz Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology Cardiovasc. Res. 87 2010 406 423
45. P. Pagliaro, D. Mancardi, R. Rastaldo, C. Penna, D. Gattullo, K.M. Miranda, M. Feelisch, D.A. Wink, D.A. Kass, and N. Paolocci Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning Free Radic. Biol. Med. 34 2003 33 43 (Pubitemid 36043884)
46. D.P. Sieveking, K.S. Woo, K.P. Fung, P. Lundman, S. Nakhla, and D.S. Celermajer Chinese herbs Danshen and Gegen modulate key early atherogenic events in vitro Int. J. Cardiol. 105 2005 40 45 (Pubitemid 41408528)
47. J.W. Starnes, B.D. Barnes, and M.E. Olsen Exercise training decreases rat heart mitochondria free radical generation but does not prevent Ca2+-induced dysfunction J. Appl. Physiol. 102 2007 1793 1798 (Pubitemid 46701946)
48. W.Y. Tam, P. Chook, M. Qiao, L.T. Chan, T.Y. Chan, Y.K. Poon, K.P. Fung, P.C. Leung, and K.S. Woo The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients J. Altern. Complement. Med. (New York, NY) 15 2009 415 421
49. P. Tyagi, and G. Tayal Ischemic preconditioning of myocardium Acta Pharmacol. Sin. 23 2002 865 870
50. L. Wu, H. Qiao, Y. Li, and L. Li Cardioprotective effects of the combined use of puerarin and Danshensu on acute ischemic myocardial injury in rats Phytother. Res. 21 2007 751 756 (Pubitemid 47217775)
51. G.H. Xie, S.Y. Rah, K.S. Yi, M.K. Han, S.W. Chae, M.J. Im, and U.H. Kim Increase of intracellular Ca(2+) during ischemia/reperfusion injury of heart is mediated by cyclic ADP-ribose Biochem. Biophys. Res. Commun. 307 2003 713 718 (Pubitemid 36944991)
52. D. Zhang, C. Lu, M. Whiteman, B. Chance, and J.S. Armstrong The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction J. Biol. Chem. 283 2008 3476 3486
53. S.Z. Zhang, Z.G. Ye, Q. Xia, W. Zhang, and I. Bruce Inhibition of mitochondrial permeability transition pore: a possible mechanism for cardioprotection conferred by pretreatment with tanshinone IIA Conf. Proc. IEEE Eng. Med. Biol. Soc. 3 2005 2276 2279 (Pubitemid 46229368)