Biochemical and enzymatic characterization of BpMP-I, a fibrinogenolytic metalloproteinase isolated from Bothropoides pauloensis snake venom

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Volumn 161, Issue 2, 2012, Pages 102-109

  Naves de Souza, Dayane L ^a,e   Gomes, Mário Sérgio R ^a,b,e   Ferreira, Francis Barbosa ^a   Rodrigues, Renata Santos ^c,e   Achê, David Collares ^a,e   Richardson, Michael ^d   Borges, Márcia Helena ^d   Rodrigues, Veridiana M ^a,e  

^a FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^b UNIVERSIDADE ESTADUAL DO SUDOESTE DA BAHIA   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^e Instituto Nacional de Ciência e Tecnologia em NanoBiofarmacêutica N BIOFAR Avenida Antônio Carlos S n   (Brazil)

Author keywords

Bothropoides pauloensis; Fibrinogenolytic; Metalloproteinase; Non hemorrhagic; Snake venom

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BOTHROPOIDES PAULOENSIS METALLOPROTEINASE I; CASEIN; EDETIC ACID; FIBRINOGEN; KALLIKREIN; MERCAPTOETHANOL; METALLOPROTEINASE; PHENANTHROLINE; PLASMIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ALKALINITY; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BOTHROPOIDES PAULOENSIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME STABILITY; HIGH TEMPERATURE; HYDROLYSIS; ION EXCHANGE CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SNAKE;

BOVINAE; MUS; VIPERIDAE;

EID: 83555179152     PISSN: 10964959     EISSN: 18791107     Source Type: Journal    
DOI: 10.1016/j.cbpb.2011.10.002     Document Type: Article

References (50)

1. Akao P.K., Tonoli C.C.C., Navarro M.S., Cintra A.C.O., Neto J.R., Arni R.K., Murakami M.T. Structural studies of BmooMPα-I, a non-hemorrhagic metalloproteinase from Bothrops moojeni venom. Toxicon 2010, 55:361-368.
2. Amaral A. A general consideration of snake poisoning and observations on Neotropical pit-viper. Contributions of Harvard Institute of Tropical Biology and Medicine 1925, 2:1-64.
3. Anai K., Sugiki M., Yoshida E., Maruyama M. Neutralization of a snake venom hemorragic metalloproteinase prevents coagulopathy after subcutaneous injection of Bothrops jararaca venom in rats. Toxicon 2002, 40:63-68.
4. Bello C.A., Hermogenes A.L.N., Magalhães A., Veiga S.S., Gremski L.H., Richardson M., Sanchez E.F. Isolation and biochemical characterization of a fibrinolytic proteinase from Bothrops leucurus (white-tailed jararaca) snake venom. Biochimie 2006, 88:189-200.
5. Berger M., Pinto A.F.M., Guimarães J.A. Purification and functional characterization of bothrojaractivase, a prothrombin-activating metalloproteinase isolated from Bothrops jararaca snake venom. Toxicon 2008, 51:488-501.
6. Bernardes C.P., Santos-Filho N.A., Costa T.R., Gomes M.S.R., Torres F.S., Costa J., Borges M.H., Richardson M., Santos D.M., Pimenta A.M.C., Homsi-Bradeburgo M.I., Soares A.M., Oliveira F. Isolation and structural characterization of a new fibrin(ogen)olytic metalloproteinase from Bothrops moojeni snake venom. Toxicon 2008, 51:574-584.
7. Bérnils R.S. Brazilian Reptiles - List Species 2010, (org.), Sociedade Brasileira de Herpetologia, (Accessible at), (Consult in 07/28/2011). http://www.sbherpetologia.org.br/.
8. Bradford M.M. A rapid and sensitive method for the qualitation of microgram quantities of protein utilizing the principle of proteine-dye binding. Anal. Biochem. 1976, 72:248-254.
9. Braud S., Bon C., Wisner A. Snake venom proteins acting on hemostasis. Biochimie 2000, 82:851-859.
10. Costa F.L.S., Rodrigues R.S., Izidoro L.F.M., Menaldo D.L., Hamaguchi A., Homsi-Brandeburgo M.I., Fuly A.L., Soares S.G., Selistre-de-Araujo H.S., Barraviera B., Soares A.M., Rodrigues V.M. Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom. Toxicon 2009, 54:725-735.
11. Costa J.O., Fonseca K.C., Mamede C.C.N., Beletti M.E., Santos-Filho N.A., Soares A.M., Arantes E.C., Hirayama S.N.S., Selistre-de-Araújo H.S., Fonseca F., Henrique-Silva F., Penha-Silva N., Oliveira F. Bhaternin: Functional and structural characterization of a new thrombin-like enzyme from Bothrops alternatus snake venom. Toxicon 2010, 55:1365-1377.
12. Cruz L.S., Vargas R., Lopes A.A. Snakebite envenomation and death in the developing world. Ethn. Dis. 2009, 19:41-46.
13. Fenwick A.M., Gutberlet R.L., Evans J.A., Parkinson C.L. Morphological and molecular evidence for phylogeny and classification of South American pitvipers, genera Bothrops, Bothriopsis, and Bothrocophias (Serpentes: Viperidae). Zool. J. Linn. Soc. 2009, 156:617-640.
14. Fox J.W., Serrano S.M.T. Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity. FEBS Lett. 2008, 275:3016-3030.
15. Gomes M.S.R., Mendes M.M., Oliveira F., Andrade R.M., Bernardes C.P., Hamaguchi A., Alcântara T.M., Soares A.M., Rodrigues V.R., Homsi-Brandeburgo M.I. BthMP: a new weakly hemorrhagic metalloproteinase from Bothrops moojeni snake venom. Toxicon 2009, 53:24-32.
16. Gomes M.S.R., Queiroz M.R., Mamede C.C.N., Mendes M.M., Hamaguchi A., Homsi-Brandeburgo M.I., Sousa M.V., Aquino E.N., Castro M.S., Oliveira F., Rodrigues V.M. Purification and functional characterization of a new metalloproteinase (BleucMP) from Bothrops leucurus snake venom. Comp. Biochem. Physiol. C 2011, 153:290-300.
17. Guan A.L., Retzios A.D., Henderson G.N., Markland F.S. Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix). Arch. Biochem. Biophys. 1991, 289:197-207.
18. Gutiérrez J.M., Rucavado A. Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage. Biochimie 2000, 82:841-850.
19. Gutiérrez J.M., Romero M., Díaz C., Borkow G., Ovadia M. Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (Terciopelo). Toxicon 1995, 33:19-29.
20. Gutiérrez J.M., Rucavado A., Escalante T., Diaz C. Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage. Toxicon 2005, 45:997-1011.
21. Hoser R. A reclassification of the rattlesnakes; species formerly exclusively referred to the genera Crotalus and Sistrurus. Aust. J. Herpet. 2009, 6:1-21.
22. Laemmli U.K. Cleavege of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
23. Laing D.G., Clissa P.B., Theakston R.D.G., Moura D.A.S., Taylor M.J. Inflammatory pathogenesis of snake venom metalloprotease-induced skin necrosis. Eur. J. Immunol. 2003, 33:3458-3463.
24. Lewis R.J., Garcia M.L. Therapeutic potential of venom peptides. Nat. Rev. Drug Discov. 2003, 2:790-802.
25. Manning M.C. Sequence analysis of fibrolase, a fibrinolytic metalloproteinase from Agkistrodon contortrix contortrix. Toxicon 1995, 33:1189-1200.
26. Marcussi S., Bernardes C.P., Santos-Filho N.A., Mazzi M.V., Oliveira C.Z., Izidoro L.F.M., Fuly A.L., Magro A.J., Braz A.S.K., Fontes M.R.M., Giglio J.R., Soares A.M. Molecular and functional characterization of a new non-hemorrhagic metalloprotease from Bothrops jararacussu snake venom with antiplatelet activity. Peptides 2007, 28:2328-2339.
27. Marsh N.A. Diagnostic uses of snake venom. Haemostasis 2001, 31:211-217.
28. Matsui T., Fujimura Y., Titani K. Snake venom proteases affecting hemostasis and thrombosis. Biochim. Biophys. Acta 2000, 1477:146-156.
29. Moreau M.E., Garbacki N., Molinaro G., Brown N., Marceau F., Adam A. The kallikrein-kinin system: current and future pharmacological targets. J. Pharmacol. Sci. 2005, 99:6-38.
30. Nikai T., Mori N., Kishida M., Sugihara H., Tu A.T. Isolation and biochemical characterization of hemorrhagic toxin from the venom of Crotalus atrox. Arch. Biochem. Biophys. 1984, 231:309-311.
31. Oliveira F., Rodrigues V.M., Borges M.H., Hamaguchi A., Giglio J.R., Homsi-Brandeburgo M.I. Purification and characterization of a new proteolytic enzyme from the venom of Bothrops moojeni (caissaca). Biochem. Mol. Biol. Int. 1999, 47:1069-1077.
32. Ramos O.H.P., Selistre-de-Araújo H.S. Snake venom metalloprotease-structure and function of catalytic and desintegrin domains. Comp. Biochem. Physiol. C 2006, 142:328-346.
33. Rodrigues, R.S. Purificação e caracterização de uma PLA2 de Bothrops pauloensis, 2006. Uberlândia. Dissertação (Mestrado em Bioquímica)- Universidade Federal de Uberlândia.
34. Rodrigues V.M., Soares A.M., Guerra-Sá R., Rodrigues V., Fontes M.R.M., Giglio J.R. Structural and functional characterization of Neuwiedase, a nonhemorrhagic fibrin(ogen)olytic metalloprotease from Bothrops neuwiedi snake venom. Arch. Biochem. Biophys. 2000, 381:213-224.
35. Rodrigues V.M., Hamaguchi A., Ferro E.A.V., Homsi-Brandeburgo M.I., Giglio J.R., Marcussi S., Araújo A.L., Malta-Neto N.R., Soares A.M. Bactericidal and neurotoxic activities of two myotoxic phospholipases A2 from Bothrops neuwiedi pauloensis snake venom. Toxicon 2004, 44:305-314.
36. Rodrigues R.S., Silva J.F., Boldrini-França J., Fonseca F.P.P., Otaviano A.R., Silva F.H., Hamaguchi A., Magro A.J., Braz A.S.K., Santos J.I., Homsi-Brandeburgo M.I., Fontes M.R.M., Fuly A.L., Soares A.M., Rodrigues V.M. Structural and functional properties of Bp-LAAO, new l-amino acid oxidase from Bothrops pauloensis snake venom. Biochimie 2009, 91:490-501.
37. Rodríguez-Acosta A., Sanchez E.F., Márquez A., Carvajal Z., Salazar A.M., Giron M.E., Estrella A., Gil A., Guerrero B. Hemostatic properties of Venezuelan Bothrops snake venoms with special reference to Bothrops isabelae venom. Toxicon 2010, 56:926-935.
38. Rucavado A., Escalante T., Teixeira C.F., Fernandes C.M., Diaz C., Gutiérrez J.M. Incrementes in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damagin toxins from the venom of the snake Bothrops asper. Mediators Inflamm. 2002, 11:121-128.
39. Sanchéz E.F., Schneider F.S., Yarleque A., Borges M.H., Richardson M., Figueiredo S.G., Evangelista K.S., Eble J.A. The novel metalloproteinase atroxlysin-I from Peruvian Bothrops atrox (Jergón) snake venom acts both on blood vessel ECM and platelets. Arch. Biochem. Biophys. 2010, 496:9-20.
40. Silva V.X., Rodrigues M.T. Taxonomic revisión of the Bothrops neuwiedi complex (Serpentes, Viperidae) with description of a new species. Phyllomedusa 2008, 7(1):45-90.
41. Silva, V.X. Revisão sistemática do complexo e Bothrops neuwiedi (Serpentes, Viperidae, Crotalinae). v. 1e 2, 2000. Tese (Doutorado em Zoologia). Instituto de Biociências da Universidade de São Paulo, São Paulo.
42. Soares A.M., Guerra-Sá R., Borja-Oliveira C.R., Rodrigues V.M., Rodrigues-Simioni L., Rodrigues V., Fontes M.R.M., Lomonte B., Gutiérrez J.M., Giglio J.R. Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A2 homologue from Bothrops neuwiedi pauloensis venom. Arch. Biochem. Biophys. 2000, 378:201-209.
43. Swenson S., Markland F.S. Snake venom fibri(ogen)lytic enzymes. Toxicon 2005, 45:1021-1039.
44. Teixeira F.P.C., Chaves F., Zamunér S.T., Fernandes C.M., Zuliani J.P., Cruz-Hofling M.A., Fernandes I., Gutiérrez J.M. Effects of neutrophil depletion in the local patological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom. Int. J. Exp. Pathol. 2005, 86:107-115.
45. Torres-Huaco F.D., Ponce-Soto L.A., Martins-de-Souza D., Marangoni S. Purification and characterization of a new weak hemorrhagic metalloproteinase BmHF-1 from Bothrops marajoensis snake venom. Protein J. 2010, 29:407-416.
46. Watanabe L., Shannon J.D., Valente R.H., Rucavado A., Alape-Girón A., Kamiguti A.S., Theakston R.D.G., Fox J.W., Gutiérrez J.M., Arni R.K. Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake that exerts multiple tissue-damaging activities. Protein Sci. 2003, 12:2273-2281.
47. White J. Snake venoms and coagulopathy. Toxicon 2005, 45:951-967.
48. Wilson K.J., Yuan P.M. Protein and peptide purification. Protein Sequencing a Practical Approach 1989, 3-41. IRL Press, Oxford, NewYork, Tokyo. J.B.C. Findlay, M.J. Geisow (Eds.).
49. Xu X.L., Liu X.H., Wu B., Liu Y., Liu W.Q., Xie Y.S., Liu L.Q. Metal-ion- and pH-induced conformational changes of acutolysin D from Agkistrodon acutus venom probed by fluorescent spectroscopy. Biopolymers 2004, 74:336-344.
50. Zhu X.Y., Zhu Z.L., Gong W.M., Teng M.K., Niu L.W. Studies on relationship between the biological activities and circular dichroism of south Anhui Dienagkistrodon acutus hemorrhagins. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 1997, 29:163-169.