Bactericidal and neurotoxic activities of two myotoxic phospholipases A2 from Bothrops neuwiedi pauloensis snake venom

Toxicon

Volumn 44, Issue 3, 2004, Pages 305-314

  Rodrigues, Veridiana M ^a   Marcussi, Silvana ^b   Cambraia, Rafael S ^b   De Araújo, Ana L ^b   Malta Neto, Natael R ^b   Hamaguchi, Amélia ^a   Ferro, Eloísa A V ^a   Homsi Brandeburgo, Maria I ^a   Giglio, José R ^c   Soares, Andreimar M ^b  

^a FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^b UNIVERSITY OF RIBEIRÃO PRETO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bactericidal activity; BnpTX I, myotoxin I from Bothrops neuwiedi pauloensis venom; Bothrops neuwiedi pauloensis; Myotoxins; Neurotoxicity; Phospholipases A2; PLA2, phospholipase A 2; Snake venom

Indexed keywords

HEPARIN; MYOTOXIN BNPTX I; MYOTOXIN BNPTX II; PHOSPHOLIPASE A2; SNAKE VENOM; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BACTERICIDAL ACTIVITY; BOTHROPS NEUWIEDI; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; EDEMA; ESCHERICHIA COLI; GEL FILTRATION CHROMATOGRAPHY; HYPOTHESIS; INCUBATION TIME; ION EXCHANGE CHROMATOGRAPHY; LETHALITY; MALE; MOUSE; MUSCLE TOXICITY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE HOMOLOGY; SNAKE; STAPHYLOCOCCUS AUREUS; STATISTICAL SIGNIFICANCE;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES; BOTHROPS; BRAZIL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CREATINE KINASE; CROTALID VENOMS; EDEMA; EDETIC ACID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; IMMUNOASSAY; MICE; MOLECULAR SEQUENCE DATA; MUSCLES; MYOBLASTS; NECROSIS; PHOSPHOLIPASES A; PHRENIC NERVE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; STAPHYLOCOCCUS AUREUS;

BOTHROPS; BOTHROPS NEUWIEDI PAULOENSIS; ESCHERICHIA COLI; SERPENTES; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 4043109863     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.06.008     Document Type: Article

References (44)

1. 2 isolated from the venom of the snake Bothrops asper (Viperidae). Rev. Biol. Trop. 36:1988;563-565
2. 2 in Bothrops snake venoms: Effects of chemical modifications on the enzymatic and pharmacological properties of bothrops toxins from Bothrops jararacussu. Biochimie. 82:2000;755-763
3. 2 from Bothrops asper snake venom. Toxicon. 39:2001;879-887
4. 2: a structural review. Toxicon. 34:1996;827-841
5. 2. Annu. Rev. Pharmacol. Toxicol. 39:1999;175-189
6. Borja-Oliveira C.R., Soares A.M., Zamuner S.R., Hyslop S., Giglio J.R., Prado-Franceschi J., Rodrigues-Simioni L. Intraspecific variation in the neurotoxic and myotoxic activities of Bothrops neuwiedi snake venoms. J. Venom. Anim. Toxins. 8:2002;88-101
7. Campbell J.A., Lamar W.W. The Venomous Reptiles of Latin America. 1989;Cornell University, New York
8. 2 from Bothrops neuwiedii venom. Arch. Biochem. Biophys. 318:1995;65-70
9. 2 isoform isolated from Bothrops neuwiedii (yararaca chica) venom with novel kinetic and chromatographic properties. Toxicon. 35:1997;1205-1215
10. 2, anticoagulant and myotoxic activities. Biochim. Biophys. Acta. 1070:1991;455-460
11. 2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties. Toxicon. 35:1997;241-252
12. 2 homologue from Bothrops neuwiedi pauloensis venom. Biochim. Biophys. Acta. 1432:1999;393-395
13. 2-homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarara chica) from Argentina. Toxicon. 37:1999;1735-1746
14. 2 Enzymes: Structure, Function and Mechanism. 1997;321-352 Wiley, Chichester
15. de Haas G.H., Postema N.M., Nieuwenhuizen W., van Deenen L.L.M. Purification and properties of phospholipase A from porcine pancreas. Biochim. Biophys. Acta. 159:1968;103-117
16. Itzhaki R.F., Gill D.M. A micro-biuret method for estimating proteins. Anal. Biochem. 9:1964;401-410
17. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685
18. 2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family. Biochem. Pharmacol. 47:1994;1509-1518
19. 2 from Bothrops asper snake venom. J. Biol. Chem. 269:1994;29867-29873
20. 2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro. Toxicon. 37:1999;141-158
21. 2 from snake venoms. Toxicon. 42:2003;307-312
22. 2 homologues from Bothrops neuwiedi pauloensis venom. Biochem. Biophys. Res. Commun. 311:2003;713-720
23. Nishioka S.A., Silveira P.V.P. A clinical and epidemiologic study of 292 cases of lance-headed viper bite in a Brazilian teaching hospital. Am. J. Trop. Med. Hyg. 47:1992;805-810
24. Ownby C.L. Structure, function and biophysical aspects of the myotoxins from snake venoms. J. Toxicol.-Toxin Rev. 17:1998;213-238
25. 2 proteins. Toxicon. 37:1999;411-445
26. 2 from Bothrops asper snake venom - synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region. Eur. J. Biochem. 253:1998;452-461
27. Rodrigues V.M., Soares A.M., Mancin A.C., Fontes M.R.M., Homsi-Brandeburgo M.I., Giglio J.R. Geographic variations in the compositions of myotoxins from Bothrops neuwiedi snake venoms: biochemical characterization and biological activity. Comp. Biochem. Physiol. 121A:1998;215-222
28. Rodrigues V.M., Soares A.M., Guera-Sá R., Rodrigues V., Fontes M.R.M., Giglio J.R. Structural and functional characterization of neuwiedase, a non-hemorrhagic fibrin(ogen)olytic metalloprotease from Bothrops neuwiedi snake venom. Arch. Biochem. Biophys. 381:2000;213-224
29. Rodrigues-Simioni L., Borgese N., Ceccarelli B. The effects of Bothrops jararacussu venom and its components on frog nerve-muscle preparation. Neuroscience. 10:1983;475-489
30. Rosenfeld G. Bucherl W., Buckley E.E. Venomous Animals and Their Venoms 2. 1971;345-403 Academic Press, New York
31. 2. Science. 250:1990;1541-1546
32. 2 enzymes: classification and characterization. Biochim. Biophys. Acta. 1488:2000;1-19
33. 2 from snake venoms: effects on catalytic and pharmacological properties. Rev. Toxicon. 42:2003;855-868
34. Soares A.M., Rodrigues V.M., Homsi-Brandeburgo M.I., Toyama M.H., Lombardi F.R., Arni R.K., Giglio J.R. A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic activity. Toxicon. 36:1998;503-516
35. Soares A.M., Pedrosa L.H.A., Fontes M.R.M., da Silva R.J., Giglio J.R. Polyacrylamide gel electrophoresis as a tool for the taxonomic identification of snakes from the Elapidae and Viperidae families. J. Venom. Anim. Toxins. 4:1998;137-142
36. Soares A.M., Andrião-Escarso S.H., Angulo Y., Lomonte B., Gutiérrez J.M., Marangoni S., Toyama M.H., Arni R.K., Giglio J.R. Structural and functional characterization of a myotoxin I from Bothrops moojeni (caissaca) snake venom. Arch. Biochem. Biophys. 373:2000;7-15
37. 2 homologue, from Bothrops neuwiedi pauloensis venom. Arch. Biochem. Biophys. 378:2000;201-209
38. 2 from Bothrops pirajai snake venom. Arch. Biochem. Biophys. 387:2001;188-196
39. 2 subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities. Int. J. Biochem. Cell Biol. 33:2001;877-888
40. 2 homologue from Bothrops jararacussu snake venom. Int. J. Biochem. Cell Biol. 34:2002;668-677
41. 2 myotoxin inhibitor protein from Bothrops moojeni snake plasma. Biochem. Biophys. Res. Comm. 302:2003;193-200
42. Spackman D.H., Stein W.H., Moore S. Automatic recording apparatus for use in the chromatography of amino acids. Anal. Chem. 30:1958;1190-1206
43. Thompson J.D., Higgins D.G., Gibson T.J. Clustal-w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic. Acids. Res. 22:1994;4673-4680
44. Vesterberg O. Isoelectric focusing of proteins in polyacrylamide gels. Biochim. Biophys. Acta. 257:1972;11-30