Enhancing and sustaining AMG 009 dissolution from a bilayer oral solid dosage form via microenvironmental pH modulation and supersaturation

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1401-1406

  Bi, Mingda ^a   Kyad, Ali ^a   Alvarez Nunez, Fernando ^a   Alvarez, Francisco ^a  

^a AMGEN INC   (United States)

Author keywords

bilayer dosage form; enhancing; matrix dosage form; microenvironmental pH; nucleation inhibitor; pH modifier; precipitation; supersaturation; sustaining; tablet dissolution

Indexed keywords

AMG 009; ANTIINFLAMMATORY AGENT; HYDROXYPROPYLMETHYLCELLULOSE; SODIUM CARBONATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DOSAGE FORM; DRUG SOLUBILITY; PH; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANTI-INFLAMMATORY AGENTS; CAPSULES; CARBONATES; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; KINETICS; METHYLCELLULOSE; PHENYLACETATES; SOLUBILITY; SULFONAMIDES; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 83555174495     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9710-2     Document Type: Article

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