Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1157-1162

  Bi, Mingda ^a   Kyad, Ali ^a   Kiang, Yuan Hon ^a   Alvarez Nunez, Fernando ^a   Alvarez, Francisco ^a  

^a AMGEN INC   (United States)

Author keywords

enhancing; microenvironmental pH; nucleation inhibitor; pH modifier; precipitation; supersaturation; sustaining; tablet dissolution

Indexed keywords

AMG 009; ANTIINFLAMMATORY AGENT; SODIUM CARBONATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; MATRIX TABLET; PH; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET DISINTEGRATION;

EID: 83555176151     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9679-x     Document Type: Article

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