Physicochemical characterization and water vapor sorption of organic solution advanced spray-dried inhalable trehalose microparticles and nanoparticles for targeted dry powder pulmonary inhalation delivery

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1420-1430

  Li, Xiaojian ^a   Mansour, Heidi M ^a  

^a University of Kentucky   (United States)

Author keywords

microparticulate nanoparticulate inhalable powders; non reducing sugar excipient; organic solution advanced spray drying; respiratory delivery; trehalose

Indexed keywords

NANOPARTICLE; ORGANIC SOLVENT; TREHALOSE;

AEROSOL; ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GLASS TRANSITION TEMPERATURE; GRAVIMETRY; HUMIDITY; LASER DIFFRACTION; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER INHALER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SOLID STATE; THERMAL ANALYSIS; TITRIMETRY; WATER CONTENT; WATER VAPOR; X RAY DIFFRACTION;

ADMINISTRATION, INHALATION; BIREFRINGENCE; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG CARRIERS; DRUG COMPOUNDING; HOT TEMPERATURE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, POLARIZATION; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POWDER DIFFRACTION; POWDERS; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TITRIMETRY; TREHALOSE; VOLATILIZATION; WATER;

EID: 83555173327     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9704-0     Document Type: Article

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