Dehydration of trehalose dihydrate at low relative humidity and ambient temperature

International Journal of Pharmaceutics

Volumn 313, Issue 1-2, 2006, Pages 87-98

  Jones, Matthew D ^a   Hooton, Jennifer C ^a,c   Dawson, Michelle L ^b   Ferrie, Alan R ^b   Price, Robert ^a  

^a University of Bath   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Atomic force microscopy; Crystals; Dry powder inhalers (DPIs); Polymorphism; Surface morphology; Transition

Indexed keywords

TREHALOSE; TREHALOSE DIHYDRATE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DEHYDRATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG STORAGE; ENVIRONMENTAL TEMPERATURE; HUMIDITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REHYDRATION; SCANNING ELECTRON MICROSCOPY; STORAGE TEMPERATURE; WATER CONTENT; X RAY POWDER DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLOGRAPHY, X-RAY; DESICCATION; EXCIPIENTS; HUMIDITY; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; SURFACE PROPERTIES; TEMPERATURE; TREHALOSE; WATER;

EID: 33645293143     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.01.026     Document Type: Article

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