Discovery of a potent HIV integrase inhibitor that leads to a prodrug with significant anti-HIV activity

ACS Medicinal Chemistry Letters

Volumn 2, Issue 12, 2011, Pages 877-881

  Seo, Byung I ^a   Uchil, Vinod R ^a   Okello, Maurice ^a   Mishra, Sanjay ^a   Ma, Xiao Hui ^a   Nishonov, Malik ^a   Shu, Qingning ^a   Chi, Guochen ^a   Nair, Vasu ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

anti HIV prodrug; CYP UGT profile; Integrase inhibitor; pyridinone

Indexed keywords

4 [5 (2,4 DIFLUOROBENZYL) 1 (2 FLUOROBENZYL) 2 OXO 1,2 DIHYDROPYRIDIN 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOIC ACID; CYTOCHROME P450; ESTER DERIVATIVE; GLUCURONOSYLTRANSFERASE; INTEGRASE INHIBITOR; PRODRUG; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 83455258317     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2001246     Document Type: Article

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