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0034723439
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362362 Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, Espeseth A, Gabryelski L, Schlief W, Blau C, Miller MD SCIENCE 2000 287 5453 646-650
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362362 Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, Espeseth A, Gabryelski L, Schlief W, Blau C, Miller MD SCIENCE 2000 287 5453 646-650
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62249209378
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570705 Japan Tobacco Inc clinical development as of October 20, 2004, Japan Tobacco Inc COMPANY WORLD WIDE WEB SITE 2004 October 20
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570705 Japan Tobacco Inc clinical development (as of October 20, 2004). Japan Tobacco Inc COMPANY WORLD WIDE WEB SITE 2004 October 20
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62249161310
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590953 Gilead and Japan Tobacco sign licensing agreement for novel HIV integrase inhibitor. Gilead Sciences Inc PRESS RELEASE 2005 March 22
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590953 Gilead and Japan Tobacco sign licensing agreement for novel HIV integrase inhibitor. Gilead Sciences Inc PRESS RELEASE 2005 March 22
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62249096115
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591479 JT concludes licensing agreement on JT's anti-HIV drug with Gilead. Japan Tobacco Inc PRESS RELEASE 2005 March 22
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591479 JT concludes licensing agreement on JT's anti-HIV drug with Gilead. Japan Tobacco Inc PRESS RELEASE 2005 March 22
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62249196675
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593293 Gilead Sciences announces early termination of Hart-Scott-Rodino waiting period for the Japan Tobacco license for JTK-303. Gilead Sciences Inc PRESS RELEASE 2005 April 04
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593293 Gilead Sciences announces early termination of Hart-Scott-Rodino waiting period for the Japan Tobacco license for JTK-303. Gilead Sciences Inc PRESS RELEASE 2005 April 04
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62249179928
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664618 Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. Sato M, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, Kawakami H, Matsuzaki Y, Watanabe W, Yamataka K, Ikeda S et al J MED CHEM 2006 49 5 1506-1508 • Structural optimization of 4-quinolone-3-carboxylic acid through the addition of 2-fluoro and 3-chloro groups to the distal benzene ring at the C5-position of the quinoline ring improved the inhibition of strand transfer and antiviral activity. The addition of a hydroxyethyl group at the 1-position of the quinolone ring further improved the inhibition of strand transfer and antiviral activity. Finally, addition of a methoxy group at the 7-position of the quinolone ring and an isopropyl group at the 1S-position of the hydroxyethyl moiety provided elvitegravir with improved inhibition of strand transfer and antiviral activity. This paper also provides a synthesis route
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664618 Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. Sato M, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, Kawakami H, Matsuzaki Y, Watanabe W, Yamataka K, Ikeda S et al J MED CHEM 2006 49 5 1506-1508 • Structural optimization of 4-quinolone-3-carboxylic acid through the addition of 2-fluoro and 3-chloro groups to the distal benzene ring at the C5-position of the quinoline ring improved the inhibition of strand transfer and antiviral activity. The addition of a hydroxyethyl group at the 1-position of the quinolone ring further improved the inhibition of strand transfer and antiviral activity. Finally, addition of a methoxy group at the 7-position of the quinolone ring and an isopropyl group at the 1S-position of the hydroxyethyl moiety provided elvitegravir with improved inhibition of strand transfer and antiviral activity. This paper also provides a synthesis route.
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62249188012
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729738 Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatmentnaive and treatment-experienced patients. DeJesus E, Berger D, Markowitz M, Cohen C, Hawkins T, Ruane P, Elion R, Farthing C, Zhong L, Cheng AK, McColl D et al JAIDS-J ACQUIR IMMUNE DEFIC SYNDR 2006 43 1 1-5 • This paper presented data from a phase I clinical trial in treatmentnaïve and treatment-experienced patients (n, 40) with HIV-1 infection, randomized to receive placebo, elvitegravir (200, 400 or 800 mg po, bid or 800 mg po, qd) or elvitegravir/ritonavir 50/100 mg po, qd, The most potent antiviral activity was observed in the 400- and 800-mg twice-daily elvitegravir groups and the elvitegravir/ritonavir group, 1.94, 1.91 and -1.99 log10 copies/ml, respectively, Pharmacokinetics were doseproportional, and increased exposure was observed when elvitegravir was coadministered with ritonavir. Elvitegravir was g
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10 copies/ml, respectively). Pharmacokinetics were doseproportional, and increased exposure was observed when elvitegravir was coadministered with ritonavir. Elvitegravir was generally well tolerated, and exhibited a similar safety profile to placebo.
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8
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34547850200
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777607 Development of integrase inhibitors for treatment of AIDS: An overview. Dubey S, Satyanarayana YD, Lavania H EUR J MED CHEM 2007 42 9 1159-1168
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777607 Development of integrase inhibitors for treatment of AIDS: An overview. Dubey S, Satyanarayana YD, Lavania H EUR J MED CHEM 2007 42 9 1159-1168
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9
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34247092052
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800621 Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors. Daelemans D, Lu R, De Clercq E, Engelman A J VIROL 2007 81 8 4381-4385
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800621 Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors. Daelemans D, Lu R, De Clercq E, Engelman A J VIROL 2007 81 8 4381-4385
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34347347164
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824806 Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137. Ramanathan S, Shen G, Cheng A, Kearney BP JAIDS-J ACQUIR IMMUNE DEFIC SYNDR 2007 45 3 274-279
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824806 Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137. Ramanathan S, Shen G, Cheng A, Kearney BP JAIDS-J ACQUIR IMMUNE DEFIC SYNDR 2007 45 3 274-279
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11
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62249219683
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829908 Effect of atazanavir/r on the steady-state pharmacokinetics of elvitegravir. Mathias A, Ramanathan S, Hinkle J, West S, Enejosa D, Kearney D ICAAC 2007 47 September 19 Abs A-1417
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829908 Effect of atazanavir/r on the steady-state pharmacokinetics of elvitegravir. Mathias A, Ramanathan S, Hinkle J, West S, Enejosa D, Kearney D ICAAC 2007 47 September 19 Abs A-1417
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12
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62249100551
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829910 A pharmacokinetic interaction between lopinavir/r and elvitegravir. Mathias A, West S, Enejosa J, Kearney B ICAAC 2007 47 September 19 Abs A-1418
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829910 A pharmacokinetic interaction between lopinavir/r and elvitegravir. Mathias A, West S, Enejosa J, Kearney B ICAAC 2007 47 September 19 Abs A-1418
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13
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34748824953
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843333 Pharmacokinetics of coadministered ritonavir-boosted elvitegravir and zidovudine, didanosine, stavudine, or abacavir. Ramanathan S, Shen G, Hinkle J, Enejosa J, Kearney BP JAIDS-J ACQUIR IMMUNE DEFIC SYNDR 2007 46 2 160-166
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843333 Pharmacokinetics of coadministered ritonavir-boosted elvitegravir and zidovudine, didanosine, stavudine, or abacavir. Ramanathan S, Shen G, Hinkle J, Enejosa J, Kearney BP JAIDS-J ACQUIR IMMUNE DEFIC SYNDR 2007 46 2 160-166
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62249090163
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843779 Drug datasheet: Isentress. DRUG DATASHEET WEBSITE 2007 October 25
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843779 Drug datasheet: Isentress. DRUG DATASHEET WEBSITE 2007 October 25
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44449155764
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915506 Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. Hombrouck A, Voet A, Van Remoortel B, Desadeleer C, De Maeyer M, Debyser Z, Witvrouw M ANTIMICROB AGENTS CHEMOTHER 2008 52 6 2069-2078
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915506 Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. Hombrouck A, Voet A, Van Remoortel B, Desadeleer C, De Maeyer M, Debyser Z, Witvrouw M ANTIMICROB AGENTS CHEMOTHER 2008 52 6 2069-2078
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926148 Resistance mutations in HIV-1 integrase selected with raltegravir or elvitegravir confer reduced susceptibility to a diverse panel of integrase inhibitors. Goethals O, Clayton R, Wagemans E, Van Ginderen M, Vos A, Geluykens P, Dockx K, Smits V, Meersseman G, Jochmans D, Hallenberger S et al ANTIVIR THER 2008 13 Suppl 3 Abs 9
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926148 Resistance mutations in HIV-1 integrase selected with raltegravir or elvitegravir confer reduced susceptibility to a diverse panel of integrase inhibitors. Goethals O, Clayton R, Wagemans E, Van Ginderen M, Vos A, Geluykens P, Dockx K, Smits V, Meersseman G, Jochmans D, Hallenberger S et al ANTIVIR THER 2008 13 Suppl 3 Abs 9
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62249103599
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927181 Gilead initiates phase III clinical trial of elvitegravir, an investigational integrase inhibitor for HIV. Gilead Sciences Inc PRESS RELEASE 2008 July 22
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927181 Gilead initiates phase III clinical trial of elvitegravir, an investigational integrase inhibitor for HIV. Gilead Sciences Inc PRESS RELEASE 2008 July 22
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937281 Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients. Xu L, Anderson J, Ferns B, Cook P, Wildfire A, Workman J, Graham S, Smit E AIDS RES HUM RETROVIRUSES 2008 24 7 1003-1007
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937281 Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients. Xu L, Anderson J, Ferns B, Cook P, Wildfire A, Workman J, Graham S, Smit E AIDS RES HUM RETROVIRUSES 2008 24 7 1003-1007
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37849002059
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939220 Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir JTK-303/GS-9137, Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Watanabe Y, Ohata Y, Doi S, Sato M, Kano M et al J VIROL 2008 82 2 764-774
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939220 Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Watanabe Y, Ohata Y, Doi S, Sato M, Kano M et al J VIROL 2008 82 2 764-774
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939223 Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase II study of elvitegravir (GS-9137, McColl DJ, Fransen S, Gupta S, Parkin N, Margot N, Chuck S, Cheng AK, Miller MD ANTIVIR THER 2007 12 Suppl 11 Abs 9 •• This abstract presented data from a phase II, 48-week clinical trial in HIV-1-infected, treatment-experienced patients (n, 278; HIV-1 RNA ≥ 1000 copies/ml) randomized to receive elvitegravir/ritonavir (20/100, 50/100 or 125/100 mg po, qd) or ritonavir-boosted comparator protease inhibitor; both groups received OBT. At week 24, a greater mean change in HIV-1 RNA levels was observed in patients receiving elvitegravir/ ritonavir (125/100 mg po, qd) with at least one active NRTI or first use of enfuvirtide, compared with patients receiving elvitegravir/ritonavir (125/100 mg po, qd) with no active drugs in the OBT, 2.1 versus -0.7 log10 copies/ ml, Data from this trial were also presente
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10 copies/ ml). Data from this trial were also presented at the International Conference on Retroviruses and Opportunistic Infections [958850].
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62249202781
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939224 In vitro cross-resistance studies of five different classes of integrase inhibitors in recombinant HIV-1. Ren C, May S, Miletti T, Bedard J ANTIVIR THER 2007 12 Suppl 3 Abs 1
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939224 In vitro cross-resistance studies of five different classes of integrase inhibitors in recombinant HIV-1. Ren C, May S, Miletti T, Bedard J ANTIVIR THER 2007 12 Suppl 3 Abs 1
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55249116493
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953643 Effect of ritonavir-boosted tipranavir or darunavir on the steady-state pharmacokinetics of elvitegravir. Mathias AA, Hinkle J, Shen G, Enejosa J, Piliero PJ, Sekar V, Mack R, Tomaka F, Kearney BP JAIDS-J ACQUIR IMMUNE DEFIC SYNDR 2008 49 2 156-162
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953643 Effect of ritonavir-boosted tipranavir or darunavir on the steady-state pharmacokinetics of elvitegravir. Mathias AA, Hinkle J, Shen G, Enejosa J, Piliero PJ, Sekar V, Mack R, Tomaka F, Kearney BP JAIDS-J ACQUIR IMMUNE DEFIC SYNDR 2008 49 2 156-162
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0034468560
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958150 Repair of gaps in retroviral DNA integration intermediates. Yoder KE, Bushman FD J VIROL 2000 74 23 11191-11200
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958150 Repair of gaps in retroviral DNA integration intermediates. Yoder KE, Bushman FD J VIROL 2000 74 23 11191-11200
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62249206484
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958158 JTK-303/GS 9137, a novel small-molecule inhibitor of HIV-1 integrase: Anti-HIV activity profile and pharmacokinetics in animals. Matsuzaki Y, Watanabe W, Yamataka K, Sato M, Enya S, Kano M, Kodama E, Matsuoka M, Ikeda S INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2006 13 Abs 508
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958158 JTK-303/GS 9137, a novel small-molecule inhibitor of HIV-1 integrase: Anti-HIV activity profile and pharmacokinetics in animals. Matsuzaki Y, Watanabe W, Yamataka K, Sato M, Enya S, Kano M, Kodama E, Matsuoka M, Ikeda S INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2006 13 Abs 508
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62249207947
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958163 Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor, GS-9137 JTK-303, Jones G, Ledford R, Yu F, Miller M, Tsiang M, McColl D INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2007 14 Abs 627
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958163 Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303). Jones G, Ledford R, Yu F, Miller M, Tsiang M, McColl D INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2007 14 Abs 627
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0036268538
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958164 Human immunodeficiency virus type 2. Reeves JD, Doms RW J GEN VIROL 2002 83 6 1253-1265
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958164 Human immunodeficiency virus type 2. Reeves JD, Doms RW J GEN VIROL 2002 83 6 1253-1265
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958843 Emergence of drug resistance mutations in human immunodeficiency virus type 2-infected subjects undergoing antiretroviral therapy. Rodes B, Holguin A, Soriano V, Dourana M, Mansinho K, Antunes F, Gonzalez-Lahoz J J CLIN MICROBIOL 2000 38 4 1370-1374
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958843 Emergence of drug resistance mutations in human immunodeficiency virus type 2-infected subjects undergoing antiretroviral therapy. Rodes B, Holguin A, Soriano V, Dourana M, Mansinho K, Antunes F, Gonzalez-Lahoz J J CLIN MICROBIOL 2000 38 4 1370-1374
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958844 HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro. Roquebert B, Damond F, Collin G, Matheron S, Peytavin G, Benard A, Campa P, Chene G, Brun-Vezinet F, Descamps D J ANTIMICROB CHEMOTHER 2008 62 5 914-920
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958844 HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro. Roquebert B, Damond F, Collin G, Matheron S, Peytavin G, Benard A, Campa P, Chene G, Brun-Vezinet F, Descamps D J ANTIMICROB CHEMOTHER 2008 62 5 914-920
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958846 Safety and pharmacokinetics of single oral dose of JTK-303/ GS 9137, a novel HIV integrase inhibitor, in healthy volunteers. Kawaguchi I, Ishikawa T, Ishibashi M, Irie S, Kakee A INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2006 13 Abs 580
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958846 Safety and pharmacokinetics of single oral dose of JTK-303/ GS 9137, a novel HIV integrase inhibitor, in healthy volunteers. Kawaguchi I, Ishikawa T, Ishibashi M, Irie S, Kakee A INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2006 13 Abs 580
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958847 Lack of clinically relevant drug interactions between ritonavir-boosted elvitegravir and TMC125. Ramanathan S, West S, Kakuda TN, Mack R, Holmes C, Kearney BP ICAAC 2007 47 September 17-20 Abs H-1049
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958847 Lack of clinically relevant drug interactions between ritonavir-boosted elvitegravir and TMC125. Ramanathan S, West S, Kakuda TN, Mack R, Holmes C, Kearney BP ICAAC 2007 47 September 17-20 Abs H-1049
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958849 Pharmacokinetics of coadministered ritonavir-boosted elvitegravir plus maraviroc. Ramanathan S, West S, Abel S, Enejosa J, Kearney BP ICAAC 2007 47 September 17-20 Abs H-1050
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958849 Pharmacokinetics of coadministered ritonavir-boosted elvitegravir plus maraviroc. Ramanathan S, West S, Abel S, Enejosa J, Kearney BP ICAAC 2007 47 September 17-20 Abs H-1050
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958850 The HIV integrase inhibitor GS-9137 demonstrates potent antiretroviral activity in treatment-experienced patients. Zolopa AR, Mullen M, Berger D, Ruane P, Hawkins T, Zhong L, Chuck S, Enejosa J, Kearney B, Cheng A INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2007 14 Abs 143LB •• This abstract presented data from a phase II, 48-week clinical trial in HIV-1-infected, treatment-experienced patients (n, 278; HIV-1 RNA ≥ 1000 copies/ml) randomized to receive elvitegravir/ritonavir (20/100, 50/100 or 125/100 mg po, qd) or ritonavir-boosted comparator PI; both groups received optimized background therapy. At week 16, the elvitegravir/ritonavir (125/100 mg po, qd) arm demonstrated statistically greater reductions in HIV-1 RNA levels compared with the PI/ritonavir arm, 1.7 versus -1.2 log10 copies/ml; p, 0.01, similar data were observed at week 24, 1.7 versus -1.2 log 10 copies/ml; p, 0.02, Data from this trial were also pre
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10 copies/ml; p = 0.02). Data from this trial were also presented at the HIV Drug Resistance Workshop [939223].
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959012 Pharmacokinetic characterization of GS-9137 an HIV integrase inhibitor dosed with ritonavir. Mathias A, Jain A, Hui J, Shen G, Kearney B INT WORKSHOP CLIN PHARMACOL HIV THER 2006 7 Abs 75 •• This abstract describes the first clinical pharmacokinetic trial demonstrating the increased bioavailability and higher systemic exposure to elvitegravir when the drug was coadministered with ritonavir. Healthy volunteers (n, 12) received elvitegravir alone (100 mg po, bid for 10 days, followed by ritonavir-boosted elvitegravir 100/100 mg po, bid for 10 days, Steady-state elimination t1/2 values were increased from 3.5 to 9.5 h by coadministration of ritonavir. Furthermore, steady-state AUCτ, Cmax and Cτ values were increased by 19.9, 11.1- and 90-fold, respectively, and relative oral bioavailability was increased by 6- to 7-fold
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τ values were increased by 19.9-, 11.1- and 90-fold, respectively, and relative oral bioavailability was increased by 6- to 7-fold.
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959013 Clinical pharmacokinetics of once-daily elvitegravir boosted by atazanavir versus ritonavir. Ramanthan S, West S, Hui J, Chuck SL, Kearney BP INT WORKSHOP CLIN PHARMACOL HIV THER 2008 9 Abs O18
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959013 Clinical pharmacokinetics of once-daily elvitegravir boosted by atazanavir versus ritonavir. Ramanthan S, West S, Hui J, Chuck SL, Kearney BP INT WORKSHOP CLIN PHARMACOL HIV THER 2008 9 Abs O18
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959015 Lack of clinically relevant drug-drug interaction between ritonavir-boosted GS-9137 (elvitegravir) and fosamprenavir/r. Ramanathan S, Mathias AA, Shen G, Holmes C, Kearney BP INT AIDS SOC CONF HIV PATHOGENESIS TREAT 2007 4 Abs WEPEB014
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959015 Lack of clinically relevant drug-drug interaction between ritonavir-boosted GS-9137 (elvitegravir) and fosamprenavir/r. Ramanathan S, Mathias AA, Shen G, Holmes C, Kearney BP INT AIDS SOC CONF HIV PATHOGENESIS TREAT 2007 4 Abs WEPEB014
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959016 Pharmacokinetic interaction between elvitegravir/ritonavir and dose-adjusted rifabutin. German PI, West S, Hui J, Kearney BP INT WORKSHOP CLIN PHARMACOL HIV THER 2008 9 Abs P19
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959016 Pharmacokinetic interaction between elvitegravir/ritonavir and dose-adjusted rifabutin. German PI, West S, Hui J, Kearney BP INT WORKSHOP CLIN PHARMACOL HIV THER 2008 9 Abs P19
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959017 Pharmacokinetic evaluation of drug interactions with ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and acid reducing agents. Ramanathan S, Shen G, Hinkle J, Enejosa J, Kearney B INT WORKSHOP CLIN PHARMACOL HIV THER 2007 8 Abs 69
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959017 Pharmacokinetic evaluation of drug interactions with ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and acid reducing agents. Ramanathan S, Shen G, Hinkle J, Enejosa J, Kearney B INT WORKSHOP CLIN PHARMACOL HIV THER 2007 8 Abs 69
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62249216327
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959018 The HIV integrase inhibitor GS-9137 (JTK-303) exhibits potent antiviral activity in treatment-naive and experienced patients. DeJesus E, Berger D, Markowitz M, Cohen C, Hawkins T, Ruane P, Elion R, Farthing C, Cheng A, Kearney B INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2006 13 Abs 160LB
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959018 The HIV integrase inhibitor GS-9137 (JTK-303) exhibits potent antiviral activity in treatment-naive and experienced patients. DeJesus E, Berger D, Markowitz M, Cohen C, Hawkins T, Ruane P, Elion R, Farthing C, Cheng A, Kearney B INT CONF RETROVIRUSES OPPORTUNISTIC INFECT 2006 13 Abs 160LB
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62249185157
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969323 HIV/AIDS surveillance report: Cases of HIV infection and AIDS in the United States and dependent areas, 2005. Centers for Disease Controls and Prevention COMPANY PUBLICATION 2007 17, Revised Edition June 28
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969323 HIV/AIDS surveillance report: Cases of HIV infection and AIDS in the United States and dependent areas, 2005. Centers for Disease Controls and Prevention COMPANY PUBLICATION 2007 Volume 17, Revised Edition June 28
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970072 Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: Implications for treatment and postexposure prophylaxis. Witvrouw M, Pannecouque C, Switzer WM, Folks TM, De Clercq E, Heneine W ANTIVIR THER 2004 9 1 57-65
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970072 Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: Implications for treatment and postexposure prophylaxis. Witvrouw M, Pannecouque C, Switzer WM, Folks TM, De Clercq E, Heneine W ANTIVIR THER 2004 9 1 57-65
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971608 Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. Goethals O, Clayton R, Van Ginderen M, Vereycken I, Wagemans E, Geluykens P, Dockx K, Strijbos R, Smits V, Vos A, Meersseman G et al J VIROL 2008 82 21 10366-10374
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971608 Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. Goethals O, Clayton R, Van Ginderen M, Vereycken I, Wagemans E, Geluykens P, Dockx K, Strijbos R, Smits V, Vos A, Meersseman G et al J VIROL 2008 82 21 10366-10374
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971609 Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. Marinello J, Marchand C, Mott BT, Bain A, Thomas CJ, Pommier Y BIOCHEMISTRY 2008 47 36 9345-9354
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971609 Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. Marinello J, Marchand C, Mott BT, Bain A, Thomas CJ, Pommier Y BIOCHEMISTRY 2008 47 36 9345-9354
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971611 Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility. Van Baelen K, Van Eygen V, Rondelez E, Stuyver LJ AIDS 2008 22 14 1877-1880
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972094 Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine. Kempf DJ, King MS, Bernstein B, Cernohous P, Bauer E, Moseley J, Gu K, Hsu A, Brun S, Sun E J INFECT DIS 2004 189 1 51-60
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972095 GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: Absence of protease resistance at 48 weeks. MacManus S, Yates PJ, Elston RC, White S, Richards N, Snowden W AIDS 2004 18 4 651-655
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972095 GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: Absence of protease resistance at 48 weeks. MacManus S, Yates PJ, Elston RC, White S, Richards N, Snowden W AIDS 2004 18 4 651-655
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