Pivotal role of apoptosis signal-regulating kinase 1 in monoclonal free light chain-mediated apoptosis

American Journal of Pathology

Volumn 180, Issue 1, 2012, Pages 41-47

  Ying, Wei Zhong ^a,b   Wang, Pei Xuan ^a,b   Sanders, Paul W ^a,b,c  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CASPASE 9; IMMUNOGLOBULIN FREE LIGHT CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INCUBATION TIME; INTRACELLULAR MEMBRANE; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY PROXIMAL TUBULE EPITHELIAL CELL; KIDNEY TUBULE EPITHELIUM; MEDIATOR; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 9; EPITHELIAL CELLS; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; KIDNEY FAILURE, CHRONIC; KIDNEY TUBULES, PROXIMAL; MAP KINASE KINASE KINASE 5; MULTIPLE MYELOMA; PROTEINURIA; RNA, SMALL INTERFERING;

EID: 83455258098     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.09.017     Document Type: Article

References (49)

1. V. Batuman, A.W. Dreisbach, J. Cyran Light-chain binding sites on renal brush-border membranes Am J Physiol 258 1990 F1259 F1265
2. V. Batuman, S. Guan Receptor-mediated endocytosis of immunoglobulin light chains by renal proximal tubule cells Am J Physiol 272 1997 F521 F530
3. V. Batuman, P.J. Verroust, G.L. Navar, J.H. Kaysen, F.O. Goda, W.C. Campbell, E. Simon, F. Pontillon, M. Lyles, J. Bruno, T.G. Hammond Myeloma light chains are ligands for cubilin (gp280) Am J Physiol 275 1998 F246 F254
4. R.B. Klassen, P.L. Allen, V. Batuman, K. Crenshaw, T.G. Hammond Light chains are a ligand for megalin J Appl Physiol 98 2005 257 263 (Pubitemid 40041255)
5. M.D. Holland, J.H. Galla, P.W. Sanders, R.G. Luke Effect of urinary pH and diatrizoate on Bence Jones protein nephrotoxicity in the rat Kidney Int 27 1985 46 50 (Pubitemid 15130684)
6. P.W. Sanders, G.A. Herrera, A. Chen, B.B. Booker, J.H. Galla Differential nephrotoxicity of low molecular weight proteins including Bence Jones proteins in the perfused rat nephron in vivo J Clin Invest 82 1988 2086 2096 (Pubitemid 19054958)
7. P.W. Sanders, G.A. Herrera, J.H. Galla Human Bence Jones protein toxicity in rat proximal tubule epithelium in vivo Kidney Int 32 1987 851 861 (Pubitemid 18015516)
8. P.W. Sanders, G.A. Herrera, R.L. Lott, J.H. Galla Morphologic alterations of the proximal tubules in light chainrelated renal disease Kidney Int 33 1988 881 889
9. A. Arimura, M. Li, V. Batuman Potential protective action of pituitary adenylate cyclaseactivating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury Blood 107 2006 661 668 (Pubitemid 43076392)
10. A. Pote, C. Zwizinski, E.E. Simon, S. Meleg-Smith, V. Batuman Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells Am J Kidney Dis 36 2000 735 744
11. S. Sengul, C. Zwizinski, V. Batuman Role of MAPK pathways in light chaininduced cytokine production in human proximal tubule cells Am J Physiol Renal Physiol 284 2003 F1245 F1254
12. M. Li, S. Balamuthusamy, E.E. Simon, V. Batuman Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells Am J Physiol Renal Physiol 295 2008 F82 F90
13. X.S. Wang, K. Diener, D. Jannuzzi, D. Trollinger, T.H. Tan, H. Lichenstein, M. Zukowski, Z. Yao Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase J Biol Chem 271 1996 31607 31611 (Pubitemid 26408622)
14. H. Ichijo, E. Nishida, K. Irie, P. ten Dijke, M. Saitoh, T. Moriguchi, M. Takagi, K. Matsumoto, K. Miyazono, Y. Gotoh Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways Science 275 1997 90 94 (Pubitemid 27020316)
15. A. Van Laethem, K. Nys, S. Van Kelst, S. Claerhout, H. Ichijo, J.R. Vandenheede, M. Garmyn, P. Agostinis Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes Free Radic Biol Med 41 2006 1361 1371 (Pubitemid 44466720)
16. T. Hatai, A. Matsuzawa, S. Inoshita, Y. Mochida, T. Kuroda, K. Sakamaki, K. Kuida, S. Yonehara, H. Ichijo, K. Takeda Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria- dependent caspase activation J Biol Chem 275 2000 26576 26581
17. M. Saitoh, H. Nishitoh, M. Fujii, K. Takeda, K. Tobiume, Y. Sawada, M. Kawabata, K. Miyazono, H. Ichijo Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1 EMBO J 17 1998 2596 2606 (Pubitemid 28221195)
18. R. Zhang, R. Al-Lamki, L. Bai, J.W. Streb, J.M. Miano, J. Bradley, W. Min Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner Circ Res 94 2004 1483 1491 (Pubitemid 38780321)
19. A. Matsuzawa, H. Ichijo Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling Biochim Biophys Acta 1780 2008 1325 1336
20. A. Matsuzawa, H. Nishitoh, K. Tobiume, K. Takeda, H. Ichijo Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice Antioxid Redox Signal 4 2002 415 425 (Pubitemid 34753381)
21. K. Tobiume, A. Matsuzawa, T. Takahashi, H. Nishitoh, K. Morita, K. Takeda, O. Minowa, K. Miyazono, T. Noda, H. Ichijo ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis EMBO Rep 2 2001 222 228 (Pubitemid 32273301)
22. K. Tobiume, M. Saitoh, H. Ichijo Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer J Cell Physiol 191 2002 95 104 (Pubitemid 34195221)
23. Y. Izumi, S. Kim-Mitsuyama, M. Yoshiyama, T. Omura, M. Shiota, A. Matsuzawa, T. Yukimura, T. Murohara, M. Takeya, H. Ichijo, J. Yoshikawa, H. Iwao Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis Arterioscler Thromb Vasc Biol 25 2005 1877 1883 (Pubitemid 41243457)
24. Y. Terada, S. Inoshita, H. Kuwana, T. Kobayashi, T. Okado, H. Ichijo, S. Sasaki Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury Biochem Biophys Res Commun 364 2007 1043 1049 (Pubitemid 350087906)
25. A.H. Kim, G. Khursigara, X. Sun, T.F. Franke, M.V. Chao Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1 Mol Cell Biol 21 2001 893 901 (Pubitemid 32104737)
26. 2, a necessary evil for cell signaling Science 312 2006 1882 1883 (Pubitemid 43993698)
27. P.X. Wang, P.W. Sanders Immunoglobulin light chains generate hydrogen peroxide J Am Soc Nephrol 18 2007 1239 1245 (Pubitemid 46536910)
28. K. Basnayake, W.Z. Ying, P.X. Wang, P.W. Sanders Immunoglobulin light chains activate tubular epithelial cells through redox signaling J Am Soc Nephrol 21 2010 1165 1173
29. W.Z. Ying, P.X. Wang, K.J. Aaron, K. Basnayake, P.W. Sanders Immunoglobulin light chains activate NF-κB in renal epithelial cells through a Src-dependent mechanism Blood 117 2011 1301 1307
30. M.J. Ryan, G. Johnson, J. Kirk, S.M. Fuerstenberg, R.A. Zager, B. Torok-Storb HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney Kidney Int 45 1994 48 57 (Pubitemid 24045991)
31. G.P. Mead, H.D. Carr-Smith, M.T. Drayson, G.J. Morgan, J.A. Child, A.R. Bradwell Serum free light chains for monitoring multiple myeloma Br J Haematol 126 2004 348 354 (Pubitemid 39005714)
32. J.H. Hanke, J.P. Gardner, R.L. Dow, P.S. Changelian, W.H. Brissette, E.J. Weringer, B.A. Pollok, P.A. Connelly Discovery of a novel, potent, and Src familyselective tyrosine kinase inhibitor Study of Lck- and FynT-dependent T cell activation J Biol Chem 271 1996 695 701
33. M. Ouyang, X. Shen Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells J Neurochem 97 2006 234 244
34. I. Berggrd, P.A. Peterson Polymeric forms of free normal k and λ chains of human immunoglobulin J Biol Chem 244 1969 4299 4307
35. P.W. Sanders, G.A. Herrera, K.A. Kirk, C.W. Old, J.H. Galla Spectrum of glomerular and tubulointerstitial renal lesions associated with monotypical immunoglobulin light chain deposition Lab Invest 64 1991 527 537
36. P.W. Sanders, B.B. Booker, J.B. Bishop, H.C. Cheung Mechanisms of intranephronal proteinaceous cast formation by low molecular weight proteins J Clin Invest 85 1990 570 576 (Pubitemid 20070067)
37. U. Kapur, K. Barton, R. Fresco, D.J. Leehey, M.M. Picken Expanding the pathologic spectrum of immunoglobulin light chain proximal tubulopathy Arch Pathol Lab Med 131 2007 1368 1372 (Pubitemid 47427590)
38. G.A. Herrera, P.W. Sanders, B.V. Reddy, J.A. Hasbargen, W.S. Hammond, J.D. Brooke Ultrastructural immunolabeling: a unique diagnostic tool in monoclonal light chainrelated renal diseases Ultrastruct Pathol 18 1994 401 416 (Pubitemid 24250257)
39. X. Li, N. Pabla, Q. Wei, G. Dong, R.O. Messing, C.Y. Wang, Z. Dong PKC-delta promotes renal tubular cell apoptosis associated with proteinuria J Am Soc Nephrol 21 2010 1115 1124
40. A.M. Khan, M. Li, S. Balamuthusamy, J.L. Maderdrut, E.E. Simon, V. Batuman Myeloma light chaininduced renal injury in mice Nephron Exp Nephrol 116 2010 e32 e41
41. Y. Izumi, S. Kim, M. Yoshiyama, Y. Izumiya, K. Yoshida, A. Matsuzawa, H. Koyama, Y. Nishizawa, H. Ichijo, J. Yoshikawa, H. Iwao Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia Circulation 108 2003 2812 2818 (Pubitemid 37498985)
42. S. Roy, S. Khanna, A. Azad, R. Schnitt, G. He, C. Weigert, H. Ichijo, C.K. Sen Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts Cardiovasc Res 87 2010 647 655
43. W.Z. Ying, K. Aaron, P.W. Sanders Dietary salt activates an endothelial proline-rich tyrosine kinase 2/c-Src/phosphatidylinositol 3-kinase complex to promote endothelial nitric oxide synthase phosphorylation Hypertension 52 2008 1134 1141
44. R.A. Kyle, M.A. Gertz, T.E. Witzig, J.A. Lust, M.Q. Lacy, A. Dispenzieri, R. Fonseca, S.V. Rajkumar, J.R. Offord, D.R. Larson, M.E. Plevak, T.M. Therneau, P.R. Greipp Review of 1027 patients with newly diagnosed multiple myeloma Mayo Clin Proc 78 2003 21 33 (Pubitemid 36033957)
45. J. Blade, P. Fernandez-Llama, F. Bosch, J. Montoliu, X.M. Lens, S. Montoto, A. Cases, A. Darnell, C. Rozman, E. Montserrat Renal failure in multiple myeloma: presenting features and predictors of outcome in 94 patients from a single institution Arch Intern Med 158 1998 1889 1893 (Pubitemid 28440861)
46. G.A. Herrera, L. Joseph, X. Gu, A. Hough, B. Barlogie Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia Arch Pathol Lab Med 128 2004 875 879 (Pubitemid 39014119)
47. P.W. Sanders, B.B. Booker Pathobiology of cast nephropathy from human Bence Jones proteins J Clin Invest 89 1992 630 639
48. K. Basnayake, C.K. Cheung, M. Sheaff, W. Fuggle, D. Kamel, S. Nakoinz, C.A. Hutchison, M. Cook, J. Stoves, A.R. Bradwell, P. Cockwell Differential progression of renal scarring and determinants of late renal recovery in sustained dialysis dependent acute kidney injury secondary to myeloma kidney J Clin Pathol 63 2010 884 887
49. C.A. Hutchison, P. Cockwell, S. Stringer, A. Bradwell, M. Cook, M.A. Gertz, A. Dispenzieri, J.L. Winters, S. Kumar, S.V. Rajkumar, R.A. Kyle, N. Leung Early reduction of serum-free light chains associates with renal recovery in myeloma kidney J Am Soc Nephrol 22 2011 1129 1136