Pharmacologic approaches to life-threatening asthma

Therapeutic Advances in Respiratory Disease

Volumn 5, Issue 6, 2011, Pages 397-408

  Rogers, Linda ^a   Reibman, Joan ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

asthma; fatal asthma; near fatal asthma

Indexed keywords

ACETYLCYSTEINE; ADRENALIN; AMINOPHYLLINE; ANESTHETIC AGENT; ANTIASTHMATIC AGENT; ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; HELIOX; HYDROCORTISONE; LEUKOTRIENE; MAGNESIUM; METHYLPREDNISOLONE; MONTELUKAST; MORPHINE; OPIATE; PREDNISOLONE 21 PHOSPHATE; PREDNISONE; PROPOFOL; STEROID; TERBUTALINE; THEOPHYLLINE;

ACUTE RESPIRATORY FAILURE; ASTHMA; COMBINATION CHEMOTHERAPY; FATALITY; FORCED EXPIRATORY VOLUME; HELIUM OXYGEN BREATHING; HUMAN; INTENSIVE CARE; METERED DOSE INHALER; MONOTHERAPY; MORTALITY; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; REVIEW;

ACUTE DISEASE; ANTI-ASTHMATIC AGENTS; ASTHMA; EMERGENCY SERVICE, HOSPITAL; HOSPITALIZATION; HUMANS; PRACTICE GUIDELINES AS TOPIC; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 83455257995     PISSN: 17534658     EISSN: 17534666     Source Type: Journal    
DOI: 10.1177/1753465811398721     Document Type: Review

References (110)

1. Alvine G.F. Rodgers P. Fitzsimmons K.M. Ahrens R.C. (1992) Disposable jet nebulizers. How reliable are they? Chest 101: 316–319.
2. Appel D. Karpel J.P. Sherman M. (1989) Epinephrine improves expiratory flow rates in patients with asthma who do not respond to inhaled metaproterenol sulfate. J Allergy Clin Immunol 84: 90–98.
3. Awadh N. Chu S. Grunfeld A. Simpson K. FitzGerald J.M. (1996) Comparison of males and females presenting with acute asthma to the emergency department. Respir Med 90: 485–489.
4. Babl F.E. Sheriff N. Borland M. Acworth J. Neutze J. Krieser D. (2008) Paediatric acute asthma management in Australia and New Zealand: practice patterns in the context of clinical practice guidelines. Arch Dis Child 93: 307–312.
5. Bag R. Bandi V. Fromm R.E. Jr Guntupalli K.K. (2002) The effect of heliox-driven bronchodilator aerosol therapy on pulmonary function tests in patients with asthma. J Asthma 39: 659–665.
6. Barnes P.J. (2009) Histone deacetylase-2 and airway disease. Ther Adv Respir Dis 3: 235–243.
7. Behbehani N.A. Al-Mane F. D–Yachkova Y. Pare P. FitzGerald J.M. (1999) Myopathy following mechanical ventilation for acute severe asthma: the role of muscle relaxants and corticosteroids. Chest 115: 1627–1631.
8. Bogie A.L. Towne D. Luckett P.M. Abramo T.J. Wiebe R.A. (2007) Comparison of intravenous terbutaline versus normal saline in pediatric patients on continuous high-dose nebulized albuterol for status asthmaticus. Pediatr Emerg Care 23: 355–361.
9. Bousquet J. Dahl R. Khaltaev N. (2007) Global alliance against chronic respiratory diseases. Eur Respir J 29: 233–239.
10. Bowton D.L. Goldsmith W.M. Haponik E.F. (1992) Substitution of metered-dose inhalers for hand-held nebulizers. Success and cost savings in a large, acute-care hospital. Chest 101: 305–308.
11. British Thoracic Society (2009) British Guideline on the Management of Asthma.
12. Brophy C. Ahmed B. Bayston S. Arnold A. McGivern D. Greenstone M. (1998) How long should Atrovent be given in acute asthma? Thorax 53: 363–367.
13. Camargo C.A. Jr Gurner D.M. Smithline H.A. Chapela R. Fabbri L.M. Green S.A. (2010) A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma. J Allergy Clin Immunol 125: 374–380.
14. Camargo C.A. Jr Smithline H.A. Malice M.P. Green S.A. Reiss T.F. (2003) A randomized controlled trial of intravenous montelukast in acute asthma. Am J Respir Crit Care Med 167: 528–533.
15. Cates C. (2003) Spacers and nebulisers for the delivery of beta-agonists in non-life-threatening acute asthma. Respir Med 97: 762–769.
16. Craven D. Kercsmar C.M. Myers T.R. O–Riordan M.A. Golonka G. Moore S. (2001) Ipratropium bromide plus nebulized albuterol for the treatment of hospitalized children with acute asthma. J Pediatr 138: 51–58.
17. Craven D.E. Goularte T.A. Make B.J. (1984) Contaminated condensate in mechanical ventilator circuits. A risk factor for nosocomial pneumonia? Am Rev Respir Dis 129: 625–628.
18. Cunnington D. Smith N. Steed K. Rosengarten P. Kelly A.M. Teichtahl H. (2005) Oral versus intravenous corticosteroids in adults hospitalised with acute asthma. Pulm Pharmacol Ther 18: 207–212.
19. Cydulka R. Davison R. Grammer L. Parker M. Mathews J.T. (1988) The use of epinephrine in the treatment of older adult asthmatics. Ann Emerg Med 17: 322–326.
20. Darioli R. Perret C. (1984) Mechanical controlled hypoventilation in status asthmaticus. Am Rev Respir Dis 129: 385–387.
21. Dhand R. (2004) Basic techniques for aerosol delivery during mechanical ventilation. Respir Care 49: 611–622.
22. Dhand R. (2007) Bronchodilator therapy in mechanically ventilated patients: patient selection and clinical outcomes. Respir Care 52: 152–153.
23. Dhand R. Mercier E. (2007) Effective inhaled drug administration to mechanically ventilated patients. Expert Opin Drug Deliv 4: 47–61.
24. Dolovich M.B. Ahrens R.C. Hess D.R. Anderson P. Dhand R. Rau J.L. (2005) Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. Chest 127: 335–371.
25. Eckert D.J. Catcheside P.G. McEvoy R.D. (2004) Blunted sensation of dyspnoea and near fatal asthma. Eur Respir J 24: 197–199.
26. Ellul-Micallef R. Borthwick R.C. McHardy G.J. (1974) The time-course of response to prednisolone in chronic bronchial asthma. Clin Sci Mol Med 47: 105–117.
27. Ellul-Micallef R. Fenech F.F. (1975) Intravenous prednisolone in chronic bronchial asthma. Thorax 30: 312–315.
28. Engel T. Dirksen A. Frolund L. Heinig J.H. Svendsen U.G. Pedersen B.K. (1990) Methylprednisolone pulse therapy in acute severe asthma. A randomized, double-blind study. Allergy 45: 224–230.
29. Fink J. Dhand R. (2000) Bronchodilator resuscitation in the emergency department. Part 2 of 2: dosing strategies. Respir Care 45: 497–512.
30. Fink J.B. Dhand R. Grychowski J. Fahey P.J. Tobin M.J. (1999) Reconciling in vitro and in vivo measurements of aerosol delivery from a metered-dose inhaler during mechanical ventilation and defining efficiency-enhancing factors. Am J Respir Crit Care Med 159: 63–68.
31. Gluck E.H. Onorato D.J. Castriotta R. (1990) Helium-oxygen mixtures in intubated patients with status asthmaticus and respiratory acidosis. Chest 98: 693–698.
32. Goggin N. Macarthur C. Parkin P.C. (2001) Randomized trial of the addition of ipratropium bromide to albuterol and corticosteroid therapy in children hospitalized because of an acute asthma exacerbation. Arch Pediatr Adolesc Med 155: 1329–1334.
33. Graham V. Lasserson T. Rowe B.H. (2001) Antibiotics for acute asthma. Cochrane Database Syst Rev 3: CD002741.
34. Greenberger P.A. Miller T.P. Lifschultz B. (1993) Circumstances surrounding deaths from asthma in Cook County (Chicago) Illinois. Allergy Proc 14: 321–326.
35. Gupta D. Keogh B. Chung K.F. Ayres J.G. Harrison D.A. Goldfrad C. (2004) Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care 8: R112–R121.
36. Guttman A. Afilalo M. Colacone A. Kreisman H. Dankoff J. (1997) The effects of combined intravenous and inhaled steroids (beclomethasone dipropionate) for the emergency treatment of acute asthma. The Asthma ED Study Group. Acad Emerg Med 4: 100–106.
37. Haller J. Mikics E. Makara G.B. (2008) The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings. Front Neuroendocrinol 29: 273–291.
38. Hamill R.J. Houston E.D. Georghiou P.R. Wright C.E. Koza M.A. Cadle R.M. (1995) An outbreak of Burkholderia (formerly Pseudomonas) cepacia respiratory tract colonization and infection associated with nebulized albuterol therapy. Ann Intern Med 122: 762–766.
39. Haskell R.J. Wong B.M. Hansen J.E. (1983) A double-blind, randomized clinical trial of methylprednisolone in status asthmaticus. Arch Intern Med 143: 1324–1327.
40. Hess D. Fisher D. Williams P. Pooler S. Kacmarek R.M. (1996) Medication nebulizer performance. Effects of diluent volume, nebulizer flow, and nebulizer brand. Chest 110: 498–505.
41. Hess D.R. Dillman C. Kacmarek R.M. (2003) In vitro evaluation of aerosol bronchodilator delivery during mechanical ventilation: pressure-control vs. volume control ventilation. Intensive Care Med 29: 1145–1150.
42. Horvath G. Wanner A. (2006) Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma. Eur Respir J 27: 172–187.
43. Hyzy R.C. Travis W.D. Hanna E. Lyon-Callo S. Flaherty K.R. Rosenman K.D. (2008) Slow-onset asthma deaths have more eosinophils and health care utilization than rapid-onset deaths. Respir Med 102: 1819–1826.
44. James A.L. Elliot J.G. Abramson M.J. Walters E.H. (2005) Time to death, airway wall inflammation and remodelling in fatal asthma. Eur Respir J 26: 429–434.
45. Jonsson S. Kjartansson G. Gislason D. Helgason H. (1988) Comparison of the oral and intravenous routes for treating asthma with methylprednisolone and theophylline. Chest 94: 723–726.
46. Kallenbach J.M. Frankel A.H. Lapinsky S.E. Thornton A.S. Blott J.A. Smith C. (1993) Determinants of near fatality in acute severe asthma. Am J Med 95: 265–272.
47. Kao C.C. Jain S. Guntupalli K.K. Bandi V. (2008) Mechanical ventilation for asthma: a 10-year experience. J Asthma 45: 552–556.
48. Kass J.E. Terregino C.A. (1999) The effect of heliox in acute severe asthma: a randomized controlled trial. Chest 116: 296–300.
49. Kikuchi Y. Okabe S. Tamura G. Hida W. Homma M. Shirato K. (1994) Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. N Engl J Med 330: 1329–1334.
50. Kress J.P. Noth I. Gehlbach B.K. Barman N. Pohlman A.S. Miller A. (2002) The utility of albuterol nebulized with heliox during acute asthma exacerbations. Am J Respir Crit Care Med 165: 1317–1321.
51. Krishnan V. Diette G.B. Rand C.S. Bilderback A.L. Merriman B. Hansel N.N. (2006) Mortality in patients hospitalized for asthma exacerbations in the United States. Am J Respir Crit Care Med 174: 633–638.
52. Kumar S.D. Brieva J.L. Danta I. Wanner A. (2000) Transient effect of inhaled fluticasone on airway mucosal blood flow in subjects with and without asthma. Am J Respir Crit Care Med 161: 918–921.
53. Kuyper L.M. Pare P.D. Hogg J.C. Lambert R.K. Ionescu D. Woods R. (2003) Characterization of airway plugging in fatal asthma. Am J Med 115: 6–11.
54. Leatherman J.W. Fluegel W.L. David W.S. Davies S.F. Iber C. (1996) Muscle weakness in mechanically ventilated patients with severe asthma. Am J Respir Crit Care Med 153: 1686–1690.
55. Levenson T. Greenberger P.A. Donoghue E.R. Lifschultz B.D. (1996) Asthma deaths confounded by substance abuse. An assessment of fatal asthma. Chest 110: 604–610.
56. Lin R.Y. Sauter D. Newman T. Sirleaf J. Walters J. Tavakol M. (1993) Continuous versus intermittent albuterol nebulization in the treatment of acute asthma. Ann Emerg Med 22: 1847–1853.
57. Loffert D.T. Ikle D. Nelson H.S. (1994) A comparison of commercial jet nebulizers. Chest 106: 1788–1792.
58. Magadle R. Berar-Yanay N. Weiner P. (2002) The risk of hospitalization and near-fatal and fatal asthma in relation to the perception of dyspnea. Chest 121: 329–333.
59. Manser R. Reid D. Abramson M. (2000) Corticosteroids for acute severe asthma in hospitalised patients. Cochrane Database Syst Rev 2: CD001740.
60. Marquette C.H. Saulnier F. Leroy O. Wallaert B. Chopin C. Demarcq J.M. (1992) Long-term prognosis of near-fatal asthma. A 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma. Am Rev Respir Dis 146: 76–81.
61. McFadden E.R. Jr Kiser R. deGroot W.J. Holmes B. Kiker R. Viser G. (1976) A controlled study of the effects of single doses of hydrocortisone on the resolution of acute attacks of asthma. Am J Med 60: 52–59.
62. McFadden E.R. Jr Warren E.L. (1997) Observations on asthma mortality. Ann Intern Med 127: 142–147.
63. Menitove S.M. Goldring R.M. (1983) Combined ventilator and bicarbonate strategy in the management of status asthmaticus. Am J Med 74: 898–901.
64. Miller D.D. Amin M.M. Palmer L.B. Shah A.R. Smaldone G.C. (2003) Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med 168: 1205–1209.
65. Montuschi P. Peters-Golden M.L. (2010) Leukotriene modifiers for asthma treatment. Clin Exp Allergy 40: 1732–1741.
66. Montuschi P. Sala A. Dahlen S.E. Folco G. (2007) Pharmacological modulation of the leukotriene pathway in allergic airway disease. Drug Discov Today 12: 404–412.
67. Mutlu G.M. Factor P. Schwartz D.E. Sznajder J.I. (2002) Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia. Crit Care Med 30: 477–480.
68. National Center for Health Statistics (2009) FastStats on Asthma. Available at: http://www.cdc.gov/NCHS/ ( accessed 22 April 2009).
69. New York Post (2010) Asthma Death Shock, New York Post, 30 August.
70. Nuhoglu Y. Atas E. Nuhoglu C. Iscan M. Ozcay S. (2005) Acute effect of nebulized budesonide in asthmatic children. J Investig Allergol Clin Immunol 15: 197–200.
71. O–Hollaren M.T. Yunginger J.W. Offord K.P. Somers M.J. O–Connell E.J. Ballard D.J. (1991) Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 324: 359–363.
72. Papo M.C. Frank J. Thompson A.E. (1993) A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children. Crit Care Med 21: 1479–1486.
73. Parameswaran K. Belda J. Rowe B.H. (2000) Addition of intravenous aminophylline to beta2-agonists in adults with acute asthma. Cochrane Database Syst Rev 4: CD002742.
74. Patrawalla P. Rogers L. Liu M. Cheng Q. Fernandez-Beros B.A. Reibman J. (2010) Environmental tobacco smoke exposure and asthma control in an adult ruban population. Am J Respir Crit Care Med 181; 2010: A2728.
75. Pendergraft T.B. Stanford R.H. Beasley R. Stempel D.A. Roberts C. McLaughlin T. (2004) Rates and characteristics of intensive care unit admissions and intubations among asthma-related hospitalizations. Ann Allergy Asthma Immunol 93: 29–35.
76. Pietinalho A. Pelkonen A. Rytila P. (2009) Linkage between smoking and asthma. Allergy 64: 1722–1727.
77. Plaza V. Serrano J. Picado C. Sanchis J. (2002) Frequency and clinical characteristics of rapid-onset fatal and near-fatal asthma. Eur Respir J 19: 846–852.
78. Quon B.S. Fitzgerald J.M. Lemiere C. Shahidi N. Ducharme F.M. (2010) Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children. Cochrane Database Syst Rev 10: CD007524.
79. Ratto D. Alfaro C. Sipsey J. Glovsky M.M. Sharma O.P. (1988) Are intravenous corticosteroids required in status asthmaticus? JAMA 260: 527–529.
80. Rodrigo C. Rodrigo G. (1998) Therapeutic response patterns to high and cumulative doses of salbutamol in acute severe asthma. Chest 113: 593–598.
81. Rodrigo G. Rodrigo C. (1993) Assessment of the patient with acute asthma in the emergency department. A factor analytic study. Chest 104: 1325–1328.
82. Rodrigo G. Rodrigo C. (1999) Ipratropium bromide in acute asthma: small beneficial effects? Chest 115: 1482.
83. Rodrigo G.J. (2006) Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation. Chest 130: 1301–1311.
84. Rodrigo G.J. Castro-Rodriguez J.A. (2005) Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis. Thorax 60: 740–746.
85. Rodrigo G. Pollack C. Rodrigo C. Rowe B.H. (2006) Heliox for nonintubated acute asthma patients. Cochrane Database Syst Rev 18(4): CD002884.
86. Rodrigo G.J. Rodrigo C. (2000) First-line therapy for adult patients with acute asthma receiving a multiple-dose protocol of ipratropium bromide plus albuterol in the emergency department. Am J Respir Crit Care Med 161: 1862–1868.
87. Rodrigo G.J. Rodrigo C. (2002) Continuous vs intermittent beta-agonists in the treatment of acute adult asthma: a systematic review with meta-analysis. Chest 122: 160–165.
88. Rodriguez-Trigo G. Plaza V. Picado C. Sanchis J. (2008) [Management according to the Global Initiative for Asthma guidelines of patients with near-fatal asthma reduces morbidity and mortality]. Arch Bronconeumol 44: 192–196.
89. Rowe B.H. Bretzlaff J.A. Bourdon C. Bota G.W. Camargo C.A. Jr (2000) Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev 2: CD001490.
90. Ruddy R.M. Kolski G. Scarpa N. Wilmott R. (1986) Aerosolized metaproterenol compared to subcutaneous epinephrine in the emergency treatment of acute childhood asthma. Pediatr Pulmonol 2: 230–236.
91. Rudnitsky G.S. Eberlein R.S. Schoffstall J.M. Mazur J.E. Spivey W.H. (1993) Comparison of intermittent and continuously nebulized albuterol for treatment of asthma in an urban emergency department. Ann Emerg Med 22: 1842–1846.
92. Ruffin R.E. Dolovich M.B. Oldenburg F.A. Jr Newhouse M.T. (1981) The preferential deposition of inhaled isoproterenol and propranolol in asthmatic patients. Chest 80(6 Suppl): 904–907.
93. Sandilands E.A. Bateman D.N. (2009) Adverse reactions associated with acetylcysteine. Clin Toxicol (Phila) 47: 81–88.
94. Sears M.R. (2008) Epidemiology of asthma exacerbations. J Allergy Clin Immunol 122: 662–668: quiz 669–670.
95. Serrano J. Plaza V. Sureda B. de Pablo J. Picado C. Bardagi S. (2006) Alexithymia: a relevant psychological variable in near-fatal asthma. Eur Respir J 28: 296–302.
96. Strauss L. Hejal R. Galan G. Dixon L. McFadden E.R. Jr (1997) Observations on the effects of aerosolized albuterol in acute asthma. Am J Respir Crit Care Med 155: 454–458.
97. Suissa S. Ernst P. Benayoun S. Baltzan M. Cai B. (2000) Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 343: 332–336.
98. Suissa S. Ernst P. Boivin J.F. Horwitz R.I. Habbick B. Cockroft D. (1994) A cohort analysis of excess mortality in asthma and the use of inhaled beta-agonists. Am J Respir Crit Care Med 149: 604–610.
99. Sung L. Osmond M.H. Klassen T.P. (1998) Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma. Acad Emerg Med 5: 209–213.
100. The Guardian (2010) School Suspends 5 Staff Over Asthma Death of Boy, Guardian.co.uk, 24 March.
101. thebottlenosewordpress.com (2010) Learning from Jarvis Williams Asthma Death, thebottlenosewordpress.com, 27 May.
102. ten Brinke A. Zwinderman A.H. Sterk P.J. Rabe K.F. Bel E.H. (2004) “Refractory” eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids. Am J Respir Crit Care Med 170: 601–605.
103. Tillmann H.C. Stuck B.A. Feuring M. Rossol-Haseroth K. Tran B.M. Losel R. (2004) Delayed genomic and acute nongenomic action of glucocorticosteroids in seasonal allergic rhinitis. Eur J Clin Invest 34: 67–73.
104. Tough S.C. Green F.H. Paul J.E. Wigle D.T. Butt J.C. (1996) Sudden death from asthma in 108 children and young adults. J Asthma 33: 179–188.
105. Travers A.H. Rowe B.H. Barker S. Jones A. Camargo C.A. Jr (2002) The effectiveness of IV beta-agonists in treating patients with acute asthma in the emergency department: a meta-analysis. Chest 122: 1200–1207.
106. US Department of Health and Human Services (2007) EPRIII: Guidelines for the Diagnosis and Management of Asthma, Vol. 07-4051. US Department of Health and Human Services, National Institutes of Health.
107. Wanner A. Horvath G. Brieva J.L. Kumar S.D. Mendes E.S. (2004) Nongenomic actions of glucocorticosteroids on the airway vasculature in asthma. Proc Am Thorac Soc 1: 235–238.
108. Wall Street Journal (2010) Suit Filed in Asthma Death, onlineWSJ.com, 4 September.
109. Yoshimine F. Hasegawa T. Suzuki E. Terada M. Koya T. Kondoh A. (2005) Contribution of aspirin-intolerant asthma to near fatal asthma based on a questionnaire survey in Niigata Prefecture, Japan. Respirology 10: 477–484.
110. Yung M. South M. (1998) Randomised controlled trial of aminophylline for severe acute asthma. Arch Dis Child 79: 405–410.