Immunomodulatory effects of palifermin (recombinant human keratinocyte growth factor) in an SLE-like model of chronic graft-versus-host disease

Scandinavian Journal of Immunology

Volumn 75, Issue 1, 2012, Pages 69-76

  Ellison, C A ^a   Lissitsyn, Y V ^a   Gheorghiu, I ^a   Gartner, J G ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; KERATINOCYTE GROWTH FACTOR; MESSENGER RNA; PALIFERMIN; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL PROTECTION; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; CRYOGLOBULINEMIA; CYTOKINE RELEASE; DISEASE MODEL; FEMALE; GENE EXPRESSION REGULATION; GLOMERULONEPHRITIS; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOBIOLOGY; IMMUNOMODULATION; KIDNEY FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SYSTEMIC LUPUS ERYTHEMATOSUS; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, ANTINUCLEAR; CROSSES, GENETIC; CYTOKINES; FIBROBLAST GROWTH FACTOR 7; FLOW CYTOMETRY; GRAFT VS HOST DISEASE; IMMUNOLOGIC FACTORS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 83455235439     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2011.02628.x     Document Type: Article

References (37)

1. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 1989;245:752-5.
2. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 1989;86:802-6.
3. Boismenu R, Havran WL. Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science 1994;266:1253-5.
4. Bottaro DP, Rubin JS, Ron D, Finch PW, Florio C, Aaronson SA. Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem 1990;265:12767-70.
5. Housley RM, Morris CF, Boyle W et al. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J Clin Invest 1994;94:1764-77.
6. Ulich TR, Yi ES, Cardiff R et al. Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor. Am J Pathol 1994;144:862-8.
7. Parrott JA, Kim G, Mosher R, Skinner MK. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. Mol Cell Endocrinol 2000;167:77-87.
8. Yi ES, Shabaik AS, Lacey DL et al. Keratinocyte growth factor causes proliferation of urothelium in vivo. J Urol 1995;154:1566-70.
9. Pierce GF, Yanagihara D, Klopchin K et al. Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor. J Exp Med 1994;179:831-40.
10. Panos RJ, Rubin JS, Csaky KG, Aaronson SA, Mason RJ. Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest 1993;92:969-77.
11. Yi ES, Williams ST, Lee H et al. Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol 1996;149:1963-70.
12. Ulich TR, Whitcomb L, Tang W et al. Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. Cancer Res 1997;57:472-5.
13. Farrell CL, Bready JV, Rex KL et al. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 1998;58:933-9.
14. Frank S, Munz B, Werner S. The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene. Oncogene 1997;14:915-21.
15. Takeoka M, Ward WF, Pollack H, Kamp DW, Panos RJ. KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. Am J Physiol 1997;272:L1174-80.
16. Rus V, Svetic A, Nguyen P, Gause WC, Via CS. Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells. J Immunol 1995;155:2396-406.
17. Nestel FP, Price KS, Seemayer TA, Lapp WS. Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease. J Exp Med 1992;175:405-13.
18. Shlomchik WD, Couzens MS, Tang CB et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 1999;285:412-5.
19. Zhang Y, Shlomchik WD, Joe G et al. APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. J Immunol 2002;169:7111-8.
20. Penack O, Holler E, van den Brink MR. Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood 2010;115:1865-72.
21. Richie ER, Gallagher MT, Trentin JJ. Prevention of graft-versus-host disease by Fab fragments derived from ALG. Transplant Proc 1973;5:873-6.
22. Woodruff JM, Eltringham JR, Casey HW. Early secondary disease in the Rhesus monkey. I. A comparative histopathologic study. Lab Invest 1969;20:499-511.
23. Price KS, Nestel FP, Lapp WS. Progressive accumulation of bacterial lipopolysaccharide in vivo during murine acute graft-versus-host disease. Scand J Immunol 1997;45:294-300.
24. Ellison CA, Natuik SA, McIntosh AR, Scully SA, Danilenko DM, Gartner JG. The role of interferon-gamma, nitric oxide and lipopolysaccharide in intestinal graft-versus-host disease developing in F1-hybrid mice. Immunology 2003;109:440-9.
25. Chu YW, Gress RE. Murine models of chronic graft-versus-host disease: insights and unresolved issues. Biol Blood Marrow Transplant 2008;14:365-78.
26. Ellison CA, Gibson IW, Hayglass KT, Gartner JG. Effect of palifermin in a murine model of graft-versus-host disease (GVHD) associated with Th2 cytokine production, autoantibody production, and glomerulonephritis. J Clin Immunol 2006;26:485-94.
27. Taneda S, Segerer S, Hudkins KL et al. Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice. Am J Pathol 2001;159:2355-69.
28. Erickson M, Morkowski S, Lehar S et al. Regulation of thymic epithelium by keratinocyte growth factor. Blood 2002;100:3269-78.
29. Bruinsma M, van Soest PL, Leenen PJ et al. Keratinocyte growth factor induces expansion of murine peripheral CD4+Foxp3+ regulatory T cells and increases their thymic output. J Immunol 2007;179:7424-30.
30. Ellison CA, Lissitsyn YV, Packiasamy JA, Leonard WJ, Gartner JG. Role of thymic stromal lymphopoietin (TSLP) in palifermin-mediated immune modulation and protection from acute murine graft-versus-host disease. J Clin Immunol 2011;31:406-13.
31. Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 1990;346:371-4.
32. Gartner JG, Merry AC, Smith CI. An analysis of pulmonary natural killer cell activity in F1-hybrid mice with acute graft-versus-host reactions. Transplantation 1988;46:879-86.
33. Ellison CA, Fischer JM, HayGlass KT, Gartner JG. Murine graft-versus-host disease in an F1-hybrid model using IFN-gamma gene knockout donors. J Immunol 1998;161:631-40.
34. Ellison CA, Makar BM, Wiseman JM, Gheorghiu I, Taniguchi M, Gartner JG. Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease. J Clin Immunol 2008;28:600-15.
35. Hess AD. Modulation of graft-versus-host disease: role of regulatory T lymphocytes. Biol Blood Marrow Transplant 2006;12:13-21.
36. Govinden R, Bhoola KD. Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther 2003;98:257-65.
37. Yildirim AO, Muyal V, John G et al. Palifermin induces alveolar maintenance programs in emphysematous mice. Am J Respir Crit Care Med 2010;181:705-17.