HILIC-MS/MS method development for targeted quantitation of metabolites: Practical considerations from a clinical diagnostic perspective

Journal of Separation Science

Volumn 34, Issue 24, 2011, Pages 3527-3537

  Rappold, Brian A ^a   Grant, Russell P ^a  

^a LABORATORY CORPORATION OF AMERICA   (United States)

Author keywords

Empirical method development; Hydrophilic interaction liquid chromatography; Metabolomics; Targeted quantitation

Indexed keywords

CHROMATOGRAPHIC TECHNIQUES; CLINICAL DIAGNOSTICS; CLINICAL UTILITY; EMPIRICAL EVALUATIONS; EMPIRICAL METHOD; HIGH-THROUGHPUT; HIGH-THROUGHPUT ANALYSIS; HILIC-MS; HILIC-MS/MS; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; METABOLOMICS; METHOD DEVELOPMENT; METHYLMALONIC ACID; MOBILE PHASE ADDITIVES; MOBILE PHASIS; MOLECULAR CLASS; NUMBER OF COMPONENTS; POLAR MOLECULES; RE-EQUILIBRATION; SENSITIVE ASSAY; TARGETED QUANTITATION;

ASSAYS; BIOMOLECULES; HYDROPHILICITY; LIQUIDS; METABOLISM; METABOLITES; THROUGHPUT;

LIQUID CHROMATOGRAPHY;

METHYLMALONIC ACID;

ARTICLE; HYDROPHILIC INTERACTION CHROMATOGRAPHY; METABOLITE; METABOLOMICS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; CLINICAL LABORATORY TECHNIQUES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ORGANIC CHEMICALS; TANDEM MASS SPECTROMETRY;

EID: 83455228790     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201100550     Document Type: Article

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