Detection of PrPres in genetically susceptible fetuses from sheep with natural scrapie

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Garza, María Carmen ^a   Fernández Borges, Natalia ^b   Bolea, Rosa ^a   Badiola, Juan José ^a   Castilla, Joaquín ^b,c   Monleón, Eva ^a,d  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b CIC BIOGUNE   (Spain)

^c BASQUE FOUNDATION FOR SCIENCE   (Spain)

^d UNIVERSITY OF LLEIDA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN PRPRES; UNCLASSIFIED DRUG; PRION PROTEIN;

AMNION FLUID; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; EWE; FEMALE; FETUS; GENE AMPLIFICATION; GENETIC SUSCEPTIBILITY; ILEOCECAL VALVE; IN VITRO STUDY; LYMPH NODE; NONHUMAN; PHARYNX; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN MISFOLDING CYCLIC AMPLIFICATION TECHNIQUE; SCRAPIE; SPLEEN; TISSUE DISTRIBUTION; VERTICAL TRANSMISSION; VIRUS TRANSMISSION; WESTERN BLOTTING; ANIMAL; AUTOMATION; GENETIC PREDISPOSITION; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; PROTEIN FOLDING; SHEEP;

ANIMALS; AUTOMATION; BLOTTING, WESTERN; FEMALE; FETUS; GENETIC PREDISPOSITION TO DISEASE; IMMUNOHISTOCHEMISTRY; PREGNANCY; PROTEIN FOLDING; PRPSC PROTEINS; SCRAPIE; SHEEP;

EID: 83455217660     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027525     Document Type: Article

References (42)

1. Prusiner SB, (1998) Prions. Proc Natl Acad Sci U S A 95: 13363-13383.
2. Sigurdson CJ, (2008) A prion disease of cervids: chronic wasting disease. Vet Res 39: 41.
3. Jeffrey M, Gonzalez L, (2007) Classical sheep transmissible spongiform encephalopathies: pathogenesis, pathological phenotypes and clinical disease. Neuropathol Appl Neurobiol 33: 373-394.
4. Miller MW, Williams ES, (2003) Prion disease: horizontal prion transmission in mule deer. Nature 425: 35-36.
5. Hoinville LJ, (1996) A review of the epidemiology of scrapie in sheep. Rev Sci Tech 15: 827-852.
6. Race R, Jenny A, Sutton D, (1998) Scrapie infectivity and proteinase K-resistant prion protein in sheep placenta, brain, spleen, and lymph node: implications for transmission and antemortem diagnosis. J Infect Dis 178: 949-953.
7. Andreoletti O, Lacroux C, Chabert A, Monnereau L, Tabouret G, et al. (2002) PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol 83: 2607-2616.
8. Tuo W, O'Rourke K, Zhuang D, Cheevers W, Spraker T, (2002) Pregnancy status and fetal prion genetics determine PrPsc accumulation in placentomes of scrapie infected shhep. PNAS 99: 6310-6315.
9. Alverson J, O'Rourke KI, Baszler TV, (2006) PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus. J Gen Virol 87: 1035-1041.
10. Hadlow WJ, Kennedy RC, Race RE, (1982) Natural infection of Suffolk sheep with scrapie virus. J Infect Dis 146: 657-664.
11. Ersdal C, Ulvund MJ, Espenes A, Benestad SL, Sarradin P, et al. (2005) Mapping PrPSc propagation in experimental and natural scrapie in sheep with different PrP genotypes. Vet Pathol 42: 258-274.
12. Caplazi P, O'Rourke K, Wolf C, Shaw D, Baszler TV, (2004) Biology of PrPsc accumulation in two natural scrapie-infected sheep flocks. J Vet Diagn Invest 16: 489-496.
13. Onodera T, Ikeda T, Muramatsu Y, Shinagawa M, (1993) Isolation of scrapie agent from the placenta of sheep with natural scrapie in Japan. Microbiol Immunol 37: 311-316.
14. Hourrigan JL, (1990) Experimentally induced bovine spongiform encephalopathy in cattle in Mission, Tex, and the control of scrapie. J Am Vet Med Assoc 196: 1678-1679.
15. Castilla J, Brun A, Diaz-San Segundo F, Salguero FJ, Gutierrez-Adan A, et al. (2005) Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model. J Virol 79: 8665-8668.
16. Gough KC, Maddison, (2010) BC Prion transmission: prion excretion and occurrence in the environment. Prion 4: 275-282.
17. Saá P, Castilla J, Soto C, (2006) Ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification. J Biol Chem 281: 35245-35252.
18. Wrathall AE, Holyoak GR, Parsonson IM, Simmons HA, (2008) Risks of transmitting ruminant spongiform encephalopathies (prion diseases) by semen and embryo transfer techniques. Theriogenology 70: 725-745.
19. Dickinson AG, Stamp JT, Renwick CC, (1974) Maternal and lateral transmission of scrapie in sheep. J Comp Pathol 84: 19-25.
20. Hoinville LJ, Tongue SC, Wilesmith JW, (2009) Evidence for maternal transmission of scrapie in naturally affected flocks. Prev Vet Med 93: 121-128.
21. Lacroux C, Simon S, Benestad SL, Maillet S, Mathey J, et al. (2008) Prions in milk from ewes incubating natural scrapie. PLoS Pathog 4: e1000238.
22. Konold T, Moore SJ, Bellworthy SJ, Simmons HA, (2008) Evidence of scrapie transmission via milk. BMC Vet Res 4: 14.
23. Maddison BC, Rees HC, Baker CA, Taema M, Bellworthy SJ, et al. (2010) Prions are secreted into the oral cavity in sheep with preclinical scrapie. J Infect Dis 201: 1672-1676.
24. Castilla J, Saá P, Soto C, (2005) Detection of prions in blood. Nat Med 11: 982-985.
25. Myagkaya G, Schellens JPM, (1981) Final stages of erythrophagocytosis in the sheep placenta. Cell and Tissue Research 214: 501-518.
26. Wooding P, Burton G, eds. (2008) Comparative placentation. pp. 17-230 Structures, Functions and Evolution. Springer ed. Verlag Berlin Heidelberg.
27. Lacroux C, Corbiere F, Tabouret G, Lugan S, Costes P, et al. (2007) Dynamics and genetics of PrPSc placental accumulation in sheep. J Gen Virol 88: 1056-1061.
28. Thorne L, Terry LA, (2008) In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie. J Gen Virol 89: 3177-3184.
29. Mishra RS, Basu S, Gu Y, Luo X, Zou WQ, et al. (2004) Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: implications for species barrier in prion uptake from the intestine. J Neurosci 24: 11280-11290.
30. Sunkesula SR, Luo X, Das D, Singh A, Singh N, (2010) Iron content of ferritin modulates its uptake by intestinal epithelium: implications for co-transport of prions. Mol Brain 3: 14.
31. Leiser R, Krebs C, Klisch K, Ebert B, Dantzer V, et al. (1997) Fetal villosity and microvasculature of the bovine placentome in the second half of gestation. J Anat 191 (Pt 4): 517-527.
32. Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, et al. (1996) Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 379: 339-343.
33. Peralta OA, Huckle WR, Eyestone WH, (2010) Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells. Differentiation 81: 68-77.
34. Haley NJ, Seelig DM, Zabel MD, Telling GC, Hoover EA, (2009) Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay. PLoS One 4: e4848.
35. Kruger D, Thomzig A, Lenz G, Kampf K, McBride P, et al. (2009) Faecal shedding, alimentary clearance and intestinal spread of prions in hamsters fed with scrapie. Vet Res 40: 4.
36. Barria MA, Mukherjee A, Gonzalez-Romero D, Morales R, Soto C, (2009) De novo generation of infectious prions in vitro produces a new disease phenotype. PLoS Pathog 5: e1000421.
37. Vargas F, Bolea R, Monleon E, Acin C, Vargas A, et al. (2005) Clinical characterisation of natural scrapie in a native Spanish breed of sheep. Vet Rec 156: 318-320.
38. Monleon E, Monzon M, Hortells P, Vargas A, Acin C, et al. (2004) Detection of PrPsc on lymphoid tissues from naturally affected scrapie animals: comparison of three visualization systems. J Histochem Cytochem 52: 145-151.
39. Monleon E, Garza MC, Sarasa R, Alvarez-Rodriguez J, Bolea R, et al. (2011) An assessment of the efficiency of PrPsc detection in rectal mucosa and third-eyelid biopsies from animals infected with scrapie. Vet Microbiol 147: 237-243.
40. Spraker TR, Gidlewski TL, Balachandran A, VerCauteren KC, Creekmore L, et al. (2006) Detection of PrP(CWD) in postmortem rectal lymphoid tissues in Rocky Mountain elk (Cervus elaphus nelsoni) infected with chronic wasting disease. J Vet Diagn Invest 18: 553-557.
41. Castilla J, Saá P, Morales R, Abid K, Maundrell K, et al. (2006) Protein misfolding cyclic amplification for diagnosis and prion propagation studies. Methods Enzymol 412: 3-21.
42. Vilotte JL, Soulier S, Essalmani R, Stinnakre MG, Vaiman D, et al. (2001) Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp. J Virol 75: 5977-5984.