Mapping PrPSc propagation in experimental and natural scrapie in sheep with different PrP genotypes

Veterinary Pathology

Volumn 42, Issue 3, 2005, Pages 258-274

  Ersdal, C ^a   Ulvund, M J ^a   Espenes, A ^a   Benestad, S L ^b   Sarradin, P ^c   Landsverk, T ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b NORWEGIAN VETERINARY INSTITUTE   (Norway)

^c CEMAGREF   (France)

Author keywords

Central and peripheral nervous tissues; ELISA; Immunohistochemistry; Lymphoid tissues; Placenta; PrpSc; Sheep scrapie; Western blot

Indexed keywords

ALANINE; ARGININE; GLUTAMINE; PRION PROTEIN; VALINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CERVICAL LYMPH NODE; CODON; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INOCULATION; LYMPHATIC SYSTEM; MALE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PEYER PATCH; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SATELLITE CELL; SCRAPIE; SHEEP; SPLEEN; TISSUE DISTRIBUTION; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; ANIMAL; GENETICS; METABOLISM; NERVOUS SYSTEM; PHYSIOLOGY;

ANIMALIA; OVIS ARIES;

AMINO ACID SUBSTITUTION; ANIMALS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; IMMUNOHISTOCHEMISTRY; LYMPHATIC SYSTEM; MALE; NERVOUS SYSTEM; PROTEIN TRANSPORT; PRPSC PROTEINS; SCRAPIE; SHEEP;

EID: 18944365333     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.42-3-258     Document Type: Article

References (50)

1. Sc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. J Gen Virol 81:3115-3126, 2000
2. Sc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb trans-mission. J Gen Virol 83:2607-2616, 2002
3. Archer F, Bachelin C, Andréoletti O, Besnard N, Perrot G, Langevin C, Le Dur A, Vilette D, Baron-Van Evercooren A, Vilotte J-L, Laude H: Cultured peripheral neuroglial cells are highly permissive to sheep prion infection. J Virol 78:482-490, 2004
4. Beekes M, Baldauf E, Diringer H: Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie. J Gen Virol 77:1925-1934, 1996
5. Beekes M, McBride PA: Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie. Neurosci Lett 278:181-184, 2000
6. Benestad SL, Sarradin P, Thu B, Schönheit J, Tranulis MA, Bratberg B: Cases of scrapie with unusual features in Norway and designation of a new type, Nor98. Vet Rec 153:202-208, 2003
7. Borchelt DR, Taraboulos A, Prusiner SB: Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem 267:16188-16199, 1992
8. Bossers A, Belt PBGM, Raymond GJ, Caughey B, de Vries R, Smits MA: Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms. Proc Natl Acad Sci USA 94:4931-4936, 1997
9. Bossers A, Schreuder BE, Muileman IH, Belt PB, Smits MA: PrP genotype contributes to determining survival times of sheep with natural scrapie. J Gen Virol 77:2669-2673, 1996
10. Bruce ME, Boyle A, Cousens S, McConnell I, Foster J, Goldmann W, Fraser H: Strain characterization of natural sheep scrapie and comparison with BSE. J Gen Virol 83:695-704, 2002
11. Bruce ME, McConnell I, Fraser H, Dickinson AG: The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis. J Gen Virol 72:595-603, 1991
12. Büeler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, Weissmann C: Mice devoid of PrP are resistant to scrapie. Cell 73:1339-1347, 1993
13. Caughey B, Raymond GJ: The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive. J Biol Chem 266:18217-18223, 1991
14. Caughey B, Raymond GJ, Ernst D, Race RE: N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state. J Virol 65:6597-6603, 1991
15. Eriksen JO, Ulvund MJ, Riber U, Lind P, Heegaard PMH: Cell surface expression of PrP on subsets of peripheral blood monocytes from sheep of different genotypes. XXth International Winter Meeting St. Moritz: Growth and Death in the Nervous System: 25, 2004.
16. Sc) in nervous and lymphoid tissues of sheep with subclinical scrapie. Vet Pathol 40:164-174, 2003
17. Follet J, Lemaire-Vieille C, Blanquet-Grossard F, Podevin-Dimster V, Lehmann S, Chauvin J, Decavel J, Varea R, Grassi J, Fontes M, Cesbron J: PrP expression and replication by Schwann cells: implications in prion spreading. J Virol 76:2434-2439, 2002
18. Fraser H: Diversity in the neuropathology of scrapie-like diseases in animals. Br Med Bull 49:792-809, 1993
19. Goldmann W, Hunter N, Benson G, Foster JD, Hope J: Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene. J Gen Virol 72:2411-2417, 1991
20. González L, Martin S, Begara-McGorum I, Hunter N, Houston F, Simmons M, Jeffrey M: Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie. J Comp Pathol 126:17-29, 2002
21. Grassi J, Comoy E, Simon S, Creminon C, Frobert Y, Trapmann S, Schimmel H, Hawkins SA, Moynagh J, Deslys JP, Wells GA: Rapid test for the preclinical post-mortem diagnosis of BSE in central nervous system tissue. Vet Rec 149:577-582, 2001
22. Groschup MH, Beekes M, McBride PA, Hardt M, Hainfellner JA, Budka H: Deposition of disease-associated prion protein involves the peripheral nervous system in experimental scrapie. Acta Neuropathol 98:453-457, 1999
23. Habel RE, St. Clair LE: Ruminant digestive system. In: The Anatomy of The Domestic Animals, ed. Getty R, 5th ed., pp. 861-915. Saunders, Philadelphia, PA 1975
24. Heggebø R, González L, Press CM, Gunnes G, Espenes A, Jeffrey M: Disease-associated PrP in the enteric nervous system of scrapie-affected Suffolk sheep. J Gen Virol 84:1327-1338, 2003
25. Sc in lymphoid tissues of lambs experimentally exposed to the scrapie agent. J Comp Pathol 128:172-181, 2003
26. Heggebø R, Press CMcL, Gunnes G, Lie KI, Tranulis MA, Ulvund M, Groschup MH, Landsverk T: Distribution of prion protein in the ileal Peyer's patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent. J Gen Virol 81:2327-2337, 2000
27. Houston EF, Halliday SI, Jeffrey M, Goldmann W, Hunter N: New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1). J Gen Virol 83:1247-1250, 2002
28. Hunter N, Foster J, Chong A, McCutcheon S, Parnham D, Eaton S, MacKenzie C, Houston F: Transmission of prion diseases by blood transfusion. J Gen Virol 83:2897-2905, 2002
29. Hunter N, Foster JD, Goldmann W, Stear MJ, Hope J, Bostock C: Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. Arch Virol 141:809-824, 1996
30. Jeffrey M, Goodsir CM, Holliman A, Higgins RJ, Bruce ME, McBride PA, Fraser JR: Determination of the frequency and distribution of vascular and parenchymal amyloid with polyclonal and N-terminal-specific PrP antibodies in scrapie-affected sheep and mice. Vet Rec 142:534-537, 1998
31. Jeffrey M, Martin S, Thomson JR, Dingwall WS, Begara-McGorum I, González L: Onset and distribution of tissue PrP accumulation in scrapie-affected Suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies. J Comp Pathol 125:48-57, 2001
32. Jeffrey M, Ryder S, Martin S, Hawkins SA, Terry L, Berthelin-Baker C, Bellworthy SJ: Oral inoculation of sheep with the agent of bovine spongiform encephalopathy (BSE). 1. Onset and distribution of disease-specific PrP accumulation in brain and viscera. J Comp Pathol 124:280-289, 2001
33. Kimberlin RH, Walker CA: Pathogenesis of mouse scrapie: evidence for neural spread of infection to the CNS. J Gen Virol 51:183-187, 1980
34. Kleitman N, Bunge RP: The Schwann cell: morphology and development. In: The Axon. Structure, Function and Pathophysiology, ed. Waxman SG, Kocsis JD, and Stys PK, pp. 97-115. Oxford University Press, New York, NY 1995
35. Künzi V, Glatzel M, Nakano MY, Greber UF, Van Leuven F, Aguzzi A: Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. J Neurosci 22:7471-7477, 2002
36. Ligios C, Jeffrey M, Ryder SJ, Bellworthy SJ, Simmons MM: Distinction of scrapie phenotypes in sheep by lesion profiling. J Comp Pathol 127:45-57, 2002
37. Maignien T, Lasmézas CI, Beringue V, Dormont D, Deslys JP: Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents. J Gen Virol 80:3035-3042, 1999
38. McBride PA, Schulz-Schaeffer WJ, Donaldson M, Bruce M, Diringer H, Kretzschmar HA, Beekes M: Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves. J Virol 75:9320-9327, 2001
39. McKibben JS: Ruminant nervous system: cervical and thoracic autonomic innervation. In: The Anatomy of Domestic Animals, ed. Getty R, 5th ed., pp. 1151-1165. Saunders, Philadelphia PA, 1975
40. Prinz M, Heikenwalder M, Junt T, Schwarz P, Glatzel M, Heppner FL, Fu Y-X, Lipp M, Aguzzi A: Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature 425:957-962, 2003
41. Prusiner SB: Novel proteinaceous infectious particles cause scrapie. Science 216:136-144, 1982
42. Reynolds JD, Morris B: The evolution and involution of Peyer's patches in fetal and postnatal sheep. Eur J Immunol 13:627-635, 1983
43. Sc detection in the preclinical diagnosis of scrapie. Vet Rec 142:564-568, 1998
44. Stahl N, Borchelt DR, Hsiao K, Prusiner SB: Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell 51:229-240, 1987
45. Tranulis MA, Osland A, Bratberg B, Ulvund MJ: Prion protein gene polymorphisms in sheep with natural scrapie and healthy controls in Norway. J Gen Virol 80:1073-1077, 1999
46. Sc accumulation in placentomes of scrapie-infected sheep. Proc Natl Acad Sci USA 99:6310-6315, 2002
47. van Keulen LJ, Vromans ME, van Zijderveld FG: Early and late pathogenesis of natural scrapie infection in sheep. APMIS 110:23-32, 2002
48. van Keulen LJM, Schreuder BEC, Meloen RH, Mooij-Harkes G, Vromans MEW, Langeveld JPM: Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. J Clin Microbiol 34:1228-1231, 1996
49. van Keulen LJM, Schreuder BEC, Vromans MEW, Langeveld JPM, Smits MA: Pathogenesis of natural scrapie in sheep. Arch Virol Suppl:57-71, 2000
50. Wood JL, McGill IS, Done SH, Bradley R: Neuropathology of scrapie: a study of the distribution patterns of brain lesions in 222 cases of natural scrapie in sheep, 1982-1991. Vet Rec 140:167-174, 1997