Evidence of scrapie transmission via milk

BMC Veterinary Research

Volumn 4, Issue , 2008, Pages

  Konold, Timm ^a,b   Moore, S J O ^a   Bellworthy, Susan J ^a   Simmons, Hugh A ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BOVIDAE; OVIS ARIES;

PRION PROTEIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMISTRY; DISEASE TRANSMISSION; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; LACTATION; MILK; RISK FACTOR; SCRAPIE; SHEEP;

ANIMALS; DISEASE TRANSMISSION, VERTICAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; LACTATION; MILK; PRPSC PROTEINS; RISK FACTORS; SCRAPIE; SHEEP;

EID: 50349101871     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-4-14     Document Type: Article

References (40)

1. Andréoletti O, Berthon P, Marc D, Sarradin P, Grosclaude J, van Keulen L, Schelcher F, Elsen JM, Lantier F: Early accumulation of PrP (Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. J Gen Virol 2000, 81:3115-3126.
2. van Keulen LJ, Vromans ME, van Zijderveld FG: Early and late pathogenesis of natural scrapie infection in sheep. APMIS 2002, 110:23-32.
3. McIntyre KM, Gubbins S, Sivam SK, Baylis M: Flock-level risk factors for scrapie in Great Britain: analysis of a 2002 anonymous postal survey. BMC Vet Res 2006, 2:25.
4. Hourrigan JL: Experimentally induced bovine spongiform encephalopathy in cattle in Mission, Tex, and the control of scrapie. J Am Vet Med Assoc 1990, 196:1678-1679.
5. Lacroux C, Corbiere F, Tabouret G, Lugan S, Costes P, Mathey J, Delmas JM, Weisbecker JL, Foucras G, Cassard H, Elsen JM, Schelcher F, Andréoletti O: Dynamics and genetics of PrPSc placental accumulation in sheep. J Gen Virol 2007, 88:1056-1061.
6. Detwiler LA, Baylis M: The epidemiology of scrapie. Rev Sci Tech 2003, 22:121-143.
7. Hadlow WJ, Kennedy RC, Race RE: Natural infection of Suffolk sheep with scrapie virus. J Infect Dis 1982, 146:657-664.
8. Pattison IH, Millson GC: Experimental transmission of scrapie to goats and sheep by the oral route. J Comp Pathol 1961, 71:171-176.
9. Castilla J, Brun A, Díaz-San Segundo F, Salguero FJ, Gutiérrez-Adán A, Pintado B, Ramírez MA, del Riego L, Torres JM: Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model. J Virol 2005, 79:8665-8668.
10. Franscini N, Gedaily AE, Matthey U, Franitza S, Sy MS, Bürkle A, Groschup M, Braun U, Zahn R: Prion protein in milk. PLoS One 2006, 1:e71.
11. Elsen JM, Amigues Y, Schelcher F, Ducrocq V, Andréoletti O, Eychenne F, Khang JV, Poivey JP, Lantier F, Laplanche JL: Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Arch Virol 1999, 144:431-445.
12. van Keulen LJM, Schreuder BE, Vromans ME, Langeveld JPM, Smits MA: Pathogenesis of natural scrapie in sheep. Arch Virol Suppl 2000:57-71.
13. Jeffrey M, González L: Classical sheep transmissible spongiform encephalopathies: pathogenesis, pathological phenotypes and clinical disease. Neuropathol Appl Neurobiol 2007, 33:373-394.
14. St Rose S, Hunter N, Matthews L, Foster J, Chase-Topping M, Kruuk L, Shaw D, Rhind S, Will R, Woolhouse M: Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies. BMC Infect Dis 2006, 6:5.
15. St Rose SG, Hunter N, Foster JD, Drummond D, McKenzie C, Parnham D, Will RG, Woolhouse MEJ, Rhind SM: Quantification of Peyer's patches in Cheviot sheep for future scrapie pathogenesis studies. Vet Immunol Immunopathol 2007, 116:163-171.
16. Reynolds JD, Morris B: The evolution and involution of Peyer's patches in fetal and postnatal sheep. Eur J Immunol 1983, 13:627-635.
17. Ryder S, Dexter G, Bellworthy S, Tongue S: Demonstration of lateral transmission of scrapie between sheep kept under natural conditions using lymphoid tissue biopsy. Res Vet Sci 2004, 76:211-217.
18. Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, Maestrale C, Cancedda MG, Madau L, Aguzzi A: PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med 2005, 11:1137-1138.
19. Hunter N, Foster J, Chong A, McCutcheon S, Parnham D, Eaton S, MacKenzie C, Houston F: Transmission of prion diseases by blood transfusion. J Gen Virol 2002, 83:2897-2905.
20. Hunter N: Scrapie and experimental BSE in sheep. Br Med Bull 2003, 66:171-183.
21. Fthenakis GC, el-Masannat ET, Booth JM, Jones JE: Somatic cell counts of ewes' milk. Br Vet J 1991, 147:575-581.
22. Green TJ: Use of somatic cell counts for detection of subclinical mastitis in ewes. Vet Rec 1984, 114:43.
23. Pernthaner A, Deutz A, Schlerka G, Baumgartner W: Untersuchungen über den Zellgehalt in Schaf-und Ziegenmilch [The cell count in sheep and goat milk]. Tierärztl Prax 1991, 19:612-616.
24. Bergonier D, de Crémoux R, Rupp R, Lagriffoul G, Berthelot X: Mastitis of dairy small ruminants. Vet Res 2003, 34:689-716.
25. Watkins GH, Jones JET: Mastitis and contagious agalactia. In Diseases of sheep Volume 15. 4th edition. Edited by: Aitken ID. Oxford, Blackwell Publishing; 2007:99-105.
26. Menzies PI, Ramanoon SZ: Mastitis of sheep and goats. Vet Clin North Am Food Anim Pract 2001, 17:333-358.
27. Ligios C, Cancedda MG, Madau L, Santucciu C, Maestrale C, Agrimi U, Ru G, Di Guardo G: PrP (Sc) deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep preclinically affected with natural scrapie. Arch Virol 2006, 151:2007-2020.
28. Wells GAH, Hawkins SAC, Green RB, Austin AR, Dexter I, Spencer YI, Chaplin MJ, Stack MJ, Dawson M: Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE) : an update. Vet Rec 1998, 142:103-106.
29. Buschmann A, Groschup MH: Highly bovine spongiform encephalopathy-sensitive transgenic mice confirm the essential restriction of infectivity to the nervous system in clinically diseased cattle. J Infect Dis 2005, 192:934-942.
30. EFSA: Opinion on the quantitative risk assessment on the residual BSE risk in sheep meat and meat products. EFSA J 2007, 442:1-44 [http://www.efsa.europa.eu/EFSA/efsa-locale-1178620753812-1178620775377.htm].
31. SEAC: 95th meeting of the Spongiform Encephalopathy Advisory Committee (7th December 2006). 2006 [http://www.seac.gov. uk/summaries/seac95- summary.pdf].
32. Bellworthy SJ, Dexter G, Stack M, Chaplin M, Hawkins SAC, Simmons MM, Jeffrey M, Martin S, González L, Hill P: Natural transmission of BSE between sheep within an experimental flock. Vet Rec 2005, 157:206.
33. Everest SJ, Thorne L, Barnicle DA, Edwards JC, Elliott H, Jackman R, Hope J: Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme. J Gen Virol 2006, 87:471-477.
34. González L, Dagleish MP, Bellworthy SJ, Sisó S, Stack MJ, Chaplin MJ, Davis LA, Hawkins SA, Hughes J, Jeffrey M: Postmortem diagnosis of preclinical and clinical scrapie in sheep by the detection of disease-associated PrP in their rectal mucosa. Vet Rec 2006, 158:325-331.
35. Espenes A, Press CM, Landsverk T, Tranulis MA, Aleksandersen M, Gunnes G, Benestad SL, Fuglestveit R, Ulvund MJ: Detection of PrP (Sc) in rectal biopsy and necropsy samples from sheep with experimental scrapie. J Comp Pathol 2006, 134:115-125.
36. Konold T, Davis A, Bone G, Bracegirdle J, Everitt S, Chaplin M, Saunders GC, Cawthraw S, Simmons MM: Clinical findings in two cases of atypical scrapie in sheep: a case report. BMC Vet Res 2007, 3:2.
37. Spiropoulos J, Casalone C, Caramelli M, Simmons MM: Immunohistochemistry for PrPSc in natural scrapie reveals patterns which are associated with the PrP genotype. Neuropathol Appl Neurobiol 2007, 33:398-409.
38. Stack MJ, Chaplin MJ, Clark J: Differentiation of prion protein glycoforms from naturally occurring sheep scrapie, sheep-passaged scrapie strains (CH1641 and SSBP1), bovine spongiform encephalopathy (BSE) cases and Romney and Cheviot breed sheep experimentally inoculated with BSE using two monoclonal antibodies. Acta Neuropathol 2002, 104:279-286.
39. Taylor DM: Inactivation of transmissible degenerative encephalopathy agents: a review. Vet J 2000, 159:10-17.
40. Cockram MS: A review of behavioural and physiological responses of sheep to stressors to identify potential behavioural signs of distress. Anim Welfare 2004, 13:283-291.