Licorice extract increases cyclophosphamide teratogenicity by upregulating the expression of cytochrome P-450 2B mRNA

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 92, Issue 6, 2011, Pages 553-559

  Park, Dongsun ^a   Yang, Yun Hui ^a   Choi, Ehn Kyoung ^a   Yang, Goeun ^a   Bae, Dae Kwon ^a   Lee, Sun Hee ^a   Kim, Tae Kyun ^a   Kyung, Jangbeen ^a   Kim, Dajeong ^a   Choi, Kyung Chul ^a   Kim, Yun Bae ^a,b  

^a Chungbuk National University   (South Korea)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cyclophosphamide; Cytochrome P 450 (CYP); Licorice; Teratogenicity

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOCHROME P450 2B; GLYCYRRHIZA EXTRACT; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CESAREAN SECTION; CLEFT PALATE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FETUS WEIGHT; GENE EXPRESSION; GESTATIONAL AGE; GLYCYRRHIZA; LIMB DEFECT; NONHUMAN; PLACENTA WEIGHT; PRIORITY JOURNAL; RAT; SKELETON MALFORMATION; SKULL DEFECT; TERATOGENICITY; UPREGULATION; URETER DILATATION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BODY WEIGHT; CYCLOPHOSPHAMIDE; CYTOCHROME P-450 CYP2B1; FEMALE; FETAL DEVELOPMENT; GLYCYRRHIZA; PLANT EXTRACTS; POLYMERASE CHAIN REACTION; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TERATOGENS; UP-REGULATION;

EID: 83455207969     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20327     Document Type: Article

References (46)

1. Akao T, Terasawa T, Hiai S, Kobashi K. 1992. Inhibitory effects of glycyrrhetic acid derivatives on 11 beta- and 3 alpha-hydroxysteroid dehydrogenases of rat liver. Chem Pharm Bull 40:3021-3024.
2. Badam L. 1997. In vitro antiviral activity of indigenous glycyrrhizin, licorice and glycyrrhizic acid (Sigma) on Japanese encephalitis virus. J Commun Disorders 29:91-92.
3. Bailey MM, Sawyer RD, Behling JE, et al. 2005. Prior exposure to indole-3-carbinol decreases the incidence of specific cyclophosphamide-induced developmental defects in mice. Birth Defects Res B 74:261-267.
4. Burke MD, Thompson S, Weaver RJ, et al. 1994. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol 48:923-936.
5. Chahoud I, Kuriyama SN, Paumgartten FJ. 2002. Maternal protein-and-energy restriction reduces the developmental toxicity of cyclophosphamide and hydroxyuria in rats. Toxicology 179:137-149.
6. Cinatl J, Morgenstern B, Bauer G, et al. 2003. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361:2045-2046.
7. Cox PJ. 1979. Cyclophosphamide cystitis-identification of acrolein as the causative agent. Biochem Pharmacol 28:2045-2049.
8. Davis EA, Morris DJ. 1991. Medicinal uses of licorice through the millennia: the good and plenty of it. Mol Cell Endocrinol 78:1-6.
9. Dawson AB. 1926. A note on the staining of the skeleton of cleared specimens with Alizarin red S. Stain Technol 1:123-124.
10. Fantel AG, Greenaway JC, Juchau MR, et al. 1979. Teratogenic bioactivation of cyclophosphamide in vitro. Life Sci 25:67-72.
11. Fiore C, Eisenhut M, Ragazzi E, et al. 2005. A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol 99:317-324.
12. Gomes-Carneiro MR, De-Oliveira AC, De-Carvalho RR, et al. 2003. Inhibition of cyclophophamide-induced teratogenesis by β-ionone. Toxicol Lett 138:205-213.
13. Hales BF. 1981. Modification of the teratogenicity and mutagenicity of cyclophosphamide with thiol compounds. Teratology 23:373-381.
14. Hales BF. 1989. Effects of phosphoramide mustard and acrolein, cytotoxic metabolites of cyclophosphamide, on mouse limb development in vitro. Teratology 40:11-20.
15. Han SY, Shin JH, Kwon SC, et al. 1995. Effects of enzyme inducers and glutathione on the embryotoxicity of cyclophosphamide in cultured rat embryos. Korean J Toxicol 11:31-36.
16. Kang HG, Lee CH, Lee KC, et al. 2003. Effects of butylated hydroxyanisole on glutathione S-transferases activity and cyclophosphamide-induced teratogenicity in rats. J Toxicol Pub Health 19:181-187.
17. Kim HJ, Lee J-E, Choi EK, Kim Y-B. 2003. Effects of butylated hydroxyanisole on glutathione S-transferases activity and teratogenicity of cyclophosphamide in mice. Korean J Lab Anim Sci 19:120-125.
18. Lee YE, Byun SK, Shin S, et al. 2005. Effect of red ginseng extract on cyclophosphamide teratogenicity in rats. Lab Anim Res 21:255-261.
19. Lin JC. 2003. Mechanism of action of glycyrrhizic acid in inhibition of Epstein Barr virus replication in vitro. Antiviral Res 59:41-47.
20. Liu Y, Li W, Li P, Deng M-C, et al. 2004. The inibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity. Biol Pharm Bull 27:1555-1560.
21. Lowry OH, Rosenbrough NJ, Farr AL, Randall R J. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
22. Manson JM, Kang YJ. 1989. The methods for assessing female reproductive and developmental toxicology. In: Hayes AW, editor. Principles and methods of toxicology. New York: Raven Press. p 311-359.
23. Marinello AJ, Bansal SK, Paul B, et al. 1984. Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450. Cancer Res 44:4615-4621.
24. Meirow D, Epstein M, Lewis H, et al. 2001. Administration of cyclophosphamide at different stages of follicular maturation in mice: effects on reproductive performance and fetal malformations. Hum Reprod 16:632-637.
25. Mirkes PE. 1985. Cyclophosphamide teratogenesis: a review. Teratog Carcinog Mutagen 5:75-88.
26. Mirkes PE, Fantel AG, Greenaway JC, Shepard TH. 1981. Teratogenicity of cyclophosphamide metabolites: phosphoramide mustard, acrolein and 4-ketocyclophosphamide in rat embryos cultured in vitro. Toxicol Appl Pharmacol 58:322-330.
27. Nishimura KA. 1974. Microdissection method for detecting thoracic visceral malformations in mouse and rat fetuses. Congenit Anom 14:23-40.
28. Ojima M, Satoh K, Gomibuchi T, Itoh N, et al. 1990. The inhibitory effects of glycyrrhizin and glycyrrhetinic acid on the metabolism of cortisol and prednisolone-in vivo and in vitro studies. Nippon Naibunpi Gakkai Zasshi 66:584-596.
29. Paolini M, Pozzetti L, Sapone A, Cantelli-Forti G. 1998. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases. Life Sci 62:571-582.
30. Paolini M, Barillari J, Broccoli M, et al. 1999. Effect of liquorice and glycyrrhizin on rat liver carcinogen metabolizing enzymes. Cancer Lett 145:35-42.
31. Park D, Jeon JH, Shin S, et al. 2009a. Green tea extract increases cyclophophamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA. Reprod Toxicol 27:79-84.
32. Park D, Kim S, Kang H, et al. 2009b. Preventive effect of piperonyl butoxide on cyclophosphamide-induced teratogenesis in rats. Birth Defects Res B Dev Reprod Toxicol 86:402-408.
33. Sasaki H, Takei M, Kobayashi M, et al. 2002. Effect of glycyrrhizin, an active component of licorice roots, on HIV replication in cultures of peripheral blood mononuclear cells from HIV-seropositive patients. Pathobiology 70:229-236.
34. Sekizawa T, Yanagi K, Itoyama Y. 2001. Glycyrrhizin increases survival of mice with herpes simplex encephalitis. Acta Virol 45:51-54.
35. Shah RM, Izadnegahdar MF, Henh BM, Young AV. 1996. In vivo/in vitro studies on the effects of cyclophosphamide on growth and differentiation of hamster palate. Anticancer Drugs 7:204-212.
36. ® extract on cyclophosphamide-induced teratogenicity in rats. Lab Anim Res 22:31-37.
37. Slott VL, Hales BF. 1987. Enhancement of embryotoxicity of acrolein, but not phosphoramide mustard, by glutathione depletion in rat embryos in vitro. Biochem Pharmacol 36:2019-2025.
38. Slott VL, Hales BF. 1988. Role of the 4-hydroxy intermediate in the in vitro embryotoxicity of cyclophosphamide and dechlorocyclophosphamide. Toxicol Appl Pharmacol 92:170-178.
39. Ujhazy E, Balonova T, Durisova M, et al. 1993. Teratogenicity of cyclophosphamide in New Zealand white rabbits. Neoplasma 40:45-49.
40. Utsunomiya T, Kobayashi M, Pollard RB, Suzuki F. 1997. Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus. Antimicrob Agents Chemother 41:551-556.
41. Vaya J, Belinky PA, Aviram M. 1997. Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic Biol Med 23:302-313.
42. Wexler P. 1998. Encyclopedia of toxicology. Vol 1. New York: Academic Press. p 392-393.
43. Wilson JG. 1965. Methods for administering agents and detecting malformations in experimental animals. In: Wilson JG, editor. Teratology. Principles and techniques. Chicago: University of Chicago Press. p 262-277.
44. Yu LJ, Drewers P, Gustafsson K, et al. 1999. In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: Impact on pharmacokinetics and antitumor activity. J Pharmacol Exp Ther 288:928-937.
45. Zemlickis D, Lishner M, Erlich R, Koren G. 1993. Teratogenicity and carcinogenicity in a twin exposed in utero to cyclophosphamide. Teratog Carcinog Mutag 13:139-143.
46. Zinke H, Woods JE. 1977. Donor pretreatment in cadaver renal transplantation. Surg Gynecol Obstet 145:183-188.