Age-dependent telomere attrition as a potential indicator of racial differences in renal growth patterns

Nephron - Experimental Nephrology

Volumn 98, Issue 3, 2004, Pages

  Tchakmakjian, L ^a   Gardner, J P ^a   Wilson, P D ^b   Kimura, M ^a   Skurnick, J ^a   Zielke, H R ^c   Aviv, A ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

African Americans; Caucasians; Hypertension; Renal growth; Sodium chloride; Telomeres

Indexed keywords

ADOLESCENT; ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CAUCASIAN; CHILD; CHROMOSOME DAMAGE; CHROMOSOME SIZE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; ETHNIC GROUP; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; KIDNEY CORTEX; KIDNEY DEVELOPMENT; KIDNEY MEDULLA; MALE; MEASUREMENT; NEWBORN; PRIORITY JOURNAL; RACE DIFFERENCE; RESTRICTION FRAGMENT; SOMATIC CELL; STATISTICAL SIGNIFICANCE; TELOMERE; CELL DIVISION; CELL PROLIFERATION; DEVELOPMENTAL STAGE; HUMAN EXPERIMENT; POSTNATAL DEVELOPMENT; AGING; AUTOPSY; COMPARATIVE STUDY; FEMALE; GROWTH, DEVELOPMENT AND AGING; KIDNEY; KIDNEY PROXIMAL TUBULE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PRESCHOOL CHILD; SODIUM INTAKE; ULTRASTRUCTURE;

ADOLESCENT; ADULT; AFRICAN AMERICANS; AGED; AGING; AUTOPSY; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; KIDNEY; KIDNEY CORTEX; KIDNEY TUBULES, PROXIMAL; MALE; MIDDLE AGED; SODIUM, DIETARY; TELOMERE;

EID: 8344262987     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080683     Document Type: Article

References (34)

1. Voors AW, Berenson GS, Dalferes ER, Webber LS, Shuler SE: Racial differences in blood pressure control. Science 1979;204:1091-1094.
2. Kilcoyne MM, Thomson GE, Branche G, Williams M, Granier C, Chiles B, Soland T: Characteristics of hypertension in the black population. Circulation 1974;50:1006-1013.
3. Aviv A, Aladjem M: Essential hypertension in Blacks: Epidemiology, characteristics, and possible roles of racial differences in sodium, potassium, and calcium regulation. Cardiovasc Drugs Ther 1990;4:335-342.
4. Vaughan ED Jr, Laragh JH, Gavras I, Buhler FR, Gavras H, Brunner HR, Baer L: Volume factor in low and normal renin essential hypertension: Treatment with either spironolactone or chlorthalidone. Am J Cardiol 1973;32:523-532.
5. Woods JW, Pittman AW, Pulliam CC, Werk EE Jr, Waider W, Allen CA: Renin profiling in hypertension and its use in treatment with propranolol and chlorthalidone. N Engl J Med 1976;294:1137-1143.
6. Materson BJ, Freis ED: VA Coop. Study Group. Propranol vs. hydrochlorothiazide as monotherapy for mild to moderate hypertension. Circulation 1981;64:iv-323.
7. Buhler FR: Antihypertensive treatment according to age, plasma renin and race. Drugs 1988;35:495-503.
8. Weir MR, Saunders E: Pharmacologic management of systemic hypertension in Blacks. Am J Cardiol 1988;61:46H-52H.
9. Burt VL, Whelton P, Rocella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D: Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 1995;25:305-313.
10. Harlan WR, Hull AL, Schmouder RL, Landis JR, Larkin FA, Thompson FE: High blood pressure in older Americans. The First National Health and Nutrition Examination Survey. Hypertension 1984;6:802-809.
11. Brenner BM, Mackenzie HS: Nephron mass as a risk factor for progression of renal disease. Kidney Int 1997;52(suppl 63):124-127.
12. Yiu V, Buka S. Zurakowski D, McCormick M, Brenner B, Jabs K: Relationship between birthweight and blood pressure in childhood. Am J Kidney Dis 1999;33:253-260.
13. Weder AB, Schork NJ: Adaptation, allometry, and hypertension. Hypertension 1994;24:145-156.
14. Keller G, Zimmer G, Mall G, Ritz E, Amann K: Nephron number in patients with primary hypertension. N Engl J Med 2003;348:101-108.
15. Hughson M, Farris AB III, Douglas-Denton R, Hoy WE, Bertram JF: Glomerular number and size in autopsy kidney: The relationship to birth weight. Kidney Int 2003;63:2113-2122.
16. Darmady EM, Offer J, Woodhouse MA: The parameters of the ageing kidney. J Pathol 1973;109:195-207.
17. Fetterman GH, Shuplock NA, Philipp FJ, Gregg HS: The growth and maturation of human glomeruli and proximal convolutions from term to adulthood: Studies by microdissection. Pediatrics 1965;35:601-619.
18. Harley CB, Vaziri H, Counter CM, Allsopp RC: The telomere hypothesis of cellular aging. Exp Gerontol 1992;27:375-382.
19. Aviv A, Harley CB: How long should telomeres be? Curr Hypertens Rep 2001;3:145-151.
20. Okuda K, Khan MY, Skurnick J, Kimura M, Aviv H, Aviv A: Telomere attrition of the human abdominal aorta: Relationships with age and atherosclerosis. Atherosclerosis 2000;152:391-398.
21. Melk A, Ramassar V, Helms LM, Moore R, Rayner D, Solez K, Halloran PF: Telomere shortening in kidneys with age. J Am Soc Nephrol 2000;11:444-453.
22. Jeanclos E, Schork NJ, Kyvik KO, Kimura M, Skurnick J, Aviv A: Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 2000;36:195-200.
23. Benetos A. Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A: Telomere length as an indicator of biologic aging. The gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 2001;37:381-385.
24. Nawrot TS, Staessen JA, Gardner JP, Aviv A: Telomere length and possible link to X-chromosome. Lancet 2004;363:507-510.
25. Slagboom PE, Droog S, Boomsma DI: Genetic determination of telomere size in humans: A twin study of three age groups. Am J Hum Genet 1994;55:876-882.
26. Wright WE, Shay JW: Cellular senescence as a human-protection mechanism: The essential role of counting. Curr Opin Genet Dev 2001;11:98-103.
27. Von Zglinicki T: Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-344.
28. Youngern K, Jeanclos E, Aviv H, Kimura M, Stock J, Hanna M, Skurnick J, Bardeguez A, Aviv A: Synchrony in telomere length of the human fetus. Hum Genet 1998;102:640-643.
29. Okuda K, Bardequez A, Gardner JP, Rodriquez P, Ganesh V, Kimura M, Skurnick J, Awad G, Aviv A: Telomere length in the newborn. Pediatr Res 2002;52:377-381.
30. Von Zglinicki T, Serra V, Lorenz M, Saretzki G, Lenzen-Grossimlighaus R, Gessner R, Risch A, Steinhagen-Thiessen E: Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and possible risk factors? Lab Invest 2000;80:1739-1747.
31. Martens UM, Zijlmans JM, Poon SS, Dragowska W, Yui J, Chavez EA, Ward RK, Lansdorp PM: Short telomeres on human chromosome 17p. Nat Genet 1998;18:76-80.
32. Butler MG, Tilburt J, DeVries A, Muralidhar B, Aue G, Hedges L, Atkinson J, Schwartz H: Comparison of chromosome telomere integrity in multiple tissues from subjects at different ages. Cancer Genet Cytogenet 1998;105:138-144.
33. Aviv A, Hollenberg NK, Weder AB: Urinary potassium excretion and sodium sensitivity in African Americans. Hypertension 2004;43:707-713.
34. Lever AF, Harrap SB: Essential hypertension: A disorder of growth with origins in childhood? J Hypertens 1992;10:101-120.