Dexamethasone decreases hepatocellular carcinoma cell sensitivity to cisplatin-lnduced apoptosis

Hepato-Gastroenterology

Volumn 58, Issue 110-111, 2011, Pages 1730-1735

  Yang, Ning ^a   Zhang, Haibin ^a   Si Ma, Hui ^a   Fu, Yong ^a   Zhao, Wenchao ^a   Li, Dongyu ^a   Yang, Guangshun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cisplatin; Dexamethasone; Hepatocellular carcinoma

Indexed keywords

CISPLATIN; DEXAMETHASONE; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL XL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL STRAIN SNU449; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; BCL-X PROTEIN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DEXAMETHASONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; STAINING AND LABELING; TUMOR CELLS, CULTURED;

EID: 83355174168     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Llovet JM, Burroughs A, Bruix J: Hepatocellular carcinoma. Lancet 2003; 362(9399):1907-1917. (Pubitemid 37518510)
2. Parkin DM, Bray F, Ferlay J, et al.: Global cancer statistics, 2002. Cancer J Clin 2005; 55(2):74-108. (Pubitemid 40372904)
3. Gassler N, Zhang C, Wenger T, et al.: Dexamethasone-induced cisplatin and gemcitabine resistance in lung carcinoma samples treated ex vivo. British J Cancer 2005; 92(6):1084-1088. (Pubitemid 40546673)
4. Hengartner MO: The biochemistry of apoptosis. Nature 2000; 407(6805):770-776.
5. Kofler R: The molecular basis of glucocorticoid-induced apoptosis of lymphoblastic leukemia cells. Histochem Cell Biol 2000; 114(1):1-7.
6. Planey SL, Litwack G: Glucocorticoid-induced apoptosis in lymphocytes. Biochem Biophys Res Commun 2000; 279(2):307-312. (Pubitemid 32016713)
7. Warr D: Standard treatment of chemotherapy-induced emesis. Support Care Cancer 1997; 5(1):12-16.
8. Ekert P, MacLusky N, Luo XP, et al.: Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (hie) by a reactive oxygen species-independent mechanism. Brain Res 1997; 747(1):9-17. (Pubitemid 27063793)
9. Macaya A, Munell F, Ferrer I, et al.: Cell death and associated c-jun induction in perinatal hypoxia-ischemia. Effect of the neuroprotective drug dexamethasone. Brain Res Mol Brain Res 1998; 56(1-2):29-37. (Pubitemid 28271658)
10. Pearl JM, Nelson DP, Schwartz SM, et al.: Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts. Ann Thorac Surg 2002; 74(3):830-836; discussion 836-837.
11. Robson H, Anderson E, Eden O, et al.: Glucocorticoid pretreatment reduces the cytotoxic effects of a variety of DNA-damaging agents on rat tibial growth-plate chondrocytes in vitro. Cancer Chemother Pharmacol 1998; 42(2):171-176. (Pubitemid 28267300)
12. Kriegler AB, Bernardo D, Verschoor SM: Protection of murine bone marrow by dexamethasone during cytotoxic chemotherapy (J). Blood, 1994; 83(1):65-71. (Pubitemid 24016517)
13. Feng Z, Marti A, Jehn B, et al.: Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J Cell Biol 1995; 131(4):1095-1103.
14. Mikosz CA, Brickley DR, Sharkey MS, et al.: Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 2001; 276(20):16649-16654.
15. Kamradt MC, Mohideen N, Krueger E, et al.: Inhibition of radiation-induced apoptosis by dexamethasone in cervical carcinoma cell lines depends upon increased hpv e6/e7. British J Cancer 2000; 82(10):1709-1716. (Pubitemid 30229583)
16. Evans-Storms RB, Cidlowski JA: Delineation of an antiapoptotic action of glucocorticoids in hepatoma cells: The role of nuclear factor-kappa b. Endocrinology 2000; 141(5):1854-1862. (Pubitemid 32274415)
17. Kruit A, Reyes-Moreno C, Newling DW, et al.: Response of pc-3 prostate cancer cells to combination therapy using irradiation with glucocorticoids or doxorubicin. Anticancer Res 1999; 19(4B):3153-3156. (Pubitemid 30042603)
18. Uozumi J, Koikawa Y, Yasumasu T, et al.: The protective effect of methylprednisolone against cisplatin-induced nephrotoxicity in patients with urothelial tumors. Int J Urol 1996; 3(5):343-347. (Pubitemid 26332116)
19. Benedetti S, Pirola B, Poliani PL, et al.: Dexamethasone inhibits the anti-tumor effect of interleukin 4 on rat experimental gliomas. Gene Ther 2003; 10(2):188-192. (Pubitemid 36582591)
20. Wolff JE, Denecke J, Jurgens H: Dexamethasone induces partial resistance to cisplatinum in c6 glioma cells. Anticancer Res 1996; 16(2):805-809. (Pubitemid 26182013)
21. Chang TC, Hung MW, Jiang SY, et al.: Dexamethasone suppresses apoptosis in a human gastric cancer cell line through modulation of bcl-x gene expression. FEBS Lett 1997; 415(1):11-15.