Structural basis for the substrate specificity of a novel β-N-acetylhexosaminidase StrH protein from Streptococcus pneumoniae R6

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43004-43012

  Jiang, Yong Liang ^a   Yu, Wei Li ^a   Zhang, Jun Wei ^a   Frolet, Cecile ^b   Di Guilmi, Anne Marie ^b   Zhou, Cong Zhao ^a   Vernet, Thierry ^b   Chen, Yuxing ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVITY ASSAYS; CATALYTIC DOMAINS; COMPLEX MODEL; ENZYMATIC ACTIVITIES; GALACTOSIDASES; GLYCOCONJUGATES; GLYCOSIDE HYDROLASES; HOST DEFENSE; KINETIC INVESTIGATIONS; N-ACETYLGLUCOSAMINE; N-ACETYLHEXOSAMINIDASE; N-TERMINAL DOMAINS; NEURAMINIDASE; SIALIC ACIDS; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL BASIS; SUBSTRATE SPECIFICITY; TANDEM REPEATS; TIM BARRELS;

CARBOXYLIC ACIDS; ENZYME ACTIVITY; SUGARS;

CRYSTAL STRUCTURE;

4 NITROPHENYL N ACETYL BETA DEXTRO GLUCOSAMINIDE; AMINOSUGAR; BETA N ACETYLGLUCOSAMINE; BETA N ACETYLGLUCOSIDE; BETA N ACETYLHEXOSAMINIDASE; CYSTEINE; GLUCOSAMINE DERIVATIVE; PROTEIN STRH; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; STREPTOCOCCUS PNEUMONIA;

BACTERIAL PROTEINS; BETA-N-ACETYLHEXOSAMINIDASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; PROTEIN STRUCTURE, SECONDARY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 83355163344     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.256578     Document Type: Article

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