Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis

Structure

Volumn 19, Issue 11, 2011, Pages 1603-1614

  Pluvinage, Benjamin ^a   Higgins, Melanie A ^a   Abbott, D Wade ^a   Robb, Craig ^a   Dalia, Ankur B ^b   Deng, Lehua ^c   Weiser, Jeffrey N ^b   Parsons, Thomas B ^d   Fairbanks, Antony J ^e   Vocadlo, David J ^c   Boraston, Alisdair B ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c SIMON FRASER UNIVERSITY   (Canada)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIDEOXY 2' METHYL ALPHA DEXTRO GLUCOPYRANOSO[2,1 D] D2' THIAZOLINE; GLYCAN; GLYCOSIDASE INHIBITOR; N ACETYL BETA GLUCOSAMINIDASE; N ACETYLGLUCOSAMINE; O (2 ACETAMIDO 2 DEOXY DEXTRO GLUCOPYRANOSYLIDENE)AMINO N PHENYLCARBAMATE; PROTEIN STRH; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; HYDROLYSIS; INNATE IMMUNITY; MOLECULAR RECOGNITION; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HOST-PATHOGEN INTERACTIONS; HYDROGEN BONDING; HYDROLYSIS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES; PROTEIN BINDING; STREPTOCOCCUS PNEUMONIAE; SURFACE PROPERTIES; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

EID: 80855144810     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.08.011     Document Type: Article

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