Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 297, Issue 1, 2009, Pages

  Isa, Katsunori ^a   García Espinosa, Maria Antonia ^a   Arnold, Amy C ^a   Pirro, Nancy T ^a   Tommasi, Ellen N ^a   Ganten, Detlev ^a   Chappell, Mark C ^a   Ferrario, Carlos M ^a   Diz, Debra I ^a,b  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody; Brain; Hypertension; Renin angiotensin system; Sympathetic nerve; Transgenic rats

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN[1-12]; ANGIOTENSIN[1-12] IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IODINE 125; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; BODY WEIGHT; BRAIN; CONTINUOUS INFUSION; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; HYPERTENSION; MALE; NONHUMAN; PLASMA OSMOLALITY; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIOIMMUNOASSAY; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE; URINE VOLUME;

ANGIOTENSINS; ANIMALS; BLOOD PRESSURE; BODY WEIGHT; BRAIN; DISEASE MODELS, ANIMAL; DRINKING; EATING; HYPERTENSION; IMMUNOGLOBULIN G; INFUSION PUMPS, IMPLANTABLE; MALE; OSMOLAR CONCENTRATION; PEPTIDE FRAGMENTS; RATS; RATS, TRANSGENIC; RENIN; TIME FACTORS; URODYNAMICS;

EID: 67650081011     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90588.2008     Document Type: Article

References (26)

1. Arnold AC, Chappell MC, Ferrario CM, Diz DI. Exogenous angiotensin-(1-12) impairs baroreflex sensitivity in the solitary tract nucleus in anesthetized Sprague-Dawley rats. FASEB J 22: 1171, 2008.
2. Averill D.B. Diz D.I. Angiotensin peptides and baroreflex control of sympathetic outflow: Pathways and mechanisms of the medulla oblongata Brain Research Bulletin 2000 51 2 119-128 DOI 10.1016/S0361-9230(99)00237-3, PII S0361923099002373 2. Averill DB, Diz DI. Angiotensin peptides and baroreflex control of sympathetic outflow: pathways and mechanisms of the medulla oblongata. Brain Res Bull 51: 119-128, 2000. (Pubitemid 30069873)
3. Casto R. Hilbig J. Schroeder G. Stock G. Atrial natriuretic factor inhibits central angiotensin II pressor responses Hypertension 1987 9 5 473-477 3. Casto R, Hilbig J, Schroeder G, Stock G. Atrial natriuretic factor inhibits central angiotensin II pressor responses. Hypertension 9: 473-477, 1987. (Pubitemid 17068764)
4. Chappell MC, Westwood BM, Pedengrass KD, Jessup JA, Ferrario CM. Distinct processing pathways for the novel peptide angiotensin-(1-12) in the serum and kidney of the hypertensive mRen2 Lewis rat. Hypertension 50: E139, 2007.
5. Diz D.I. Jessup J.A. Westwood B.M. Bosch S.M. Vinsant S. Gallagher P.E. Averill D.B. Angiotensin peptides as neurotransmitters/neuromodulators in the dorsomedial medulla Clinical and Experimental Pharmacology and Physiology 2002 29 5 6 473-482 DOI 10.1046/j.1440-1681.2002.03659.x 5. Diz DI, Jessup JA, Westwood BM, Bosch SM, Vinsant S, Gallagher PE, Averill DB. Angiotensin peptides as neurotransmitters/neuromodulators in the dorsomedial medulla. Clin Exp Pharmacol Physiol 29: 473-482, 2002. (Pubitemid 34535372)
6. Diz DI, Kasper SO, Sakima A, Ferrario CM. Aging and the brain renin-angiotensin system: insights from studies in transgenic rats. Cleve Clin J Med 74 Suppl 1: S95-S98, 2007.
7. Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell AT, Sowers JR. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol Heart Circ Physiol 296: H2242-H2247, 2009.
8. Franci C.R. Kozlowski G.P. McCann S.M. Water intake in rats subjected to hypothalamic immunoneutralization of angiotensin II, atrial natriuretic peptide, vasopressin, or oxytocin Proceedings of the National Academy of Sciences of the United States of America 1989 86 8 2952-2956 DOI 10.1073/pnas.86.8.2952 8. Franci CR, Kozlowski GP, McCann SM. Water intake in rats subjected to hypothalamic immunoneutralization of angiotensin II, atrial natriuretic peptide, vasopressin, or oxytocin. Proc Natl Acad Sci USA 86: 2952-2956, 1989. (Pubitemid 19112655)
9. Ganong WF. The brain and the renin-angiotensin system. In: Central Nervous System Mechanisms in Hypertension, edited by Buckley JP and Ferrario CM. New York: Raven, 1981, p. 283-291.
10. Garcia-Espinosa MA, Chappell MC, Ganten D, Ferrario CM, Diz DI. Chronic intracerebroventricular AT1 receptor blockade, but not renin inhibition, normalizes blood pressure in (mRen2)27 transgenic rats [Online]. FASEB J 22: 953.10, 2008.
11. Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Chappell MC, Ferrario CM, Diz DI. Angiotensin-(1-12) contributes to renin-independent angiotensin II activity in brain [Online]. Hypertension 52: e81, 2008.
12. Iyer S.N. Chappell M.C. Averill D.B. Diz D.I. Ferrario C.M. Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan Hypertension 1998 31 2 699-705 12. Iyer SN, Chappell MC, Averill DB, Diz DI, Ferrario CM. Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan. Hypertension 31: 699-705, 1998. (Pubitemid 28086958)
13. Iyer S.N. Yamada K. Diz D.I. Ferrario C.M. Chappell M.C. Evidence that prostaglandins mediate the antihypertensive actions of angiotensin-(1-7) during chronic blockade of the renin-angiotensin system Journal of Cardiovascular Pharmacology 2000 36 1 109-117 13. Iyer SN, Yamada K, Diz DI, Ferrario CM, Chappell MC. Evidence that prostaglandins mediate the antihypertensive actions of angiotensin-(1-7) during chronic blockade of the renin-angiotensin system. J Cardiovasc Pharmacol 36: 109-117, 2000. (Pubitemid 30419130)
14. Jessup JA, Trask AJ, Chappell MC, Nagata S, Kato J, Kitamura K, Ferrario CM. Localization of the novel angiotensin peptide, Angiotensin-12 [Ang-(1-12)], in heart and kidney of hypertensive and normotensive rats. Am J Physiol Heart Circ Physiol 294: H2614-H2618, 2008.
15. Moriguchi A. Brosnihan K.B. Kumagai H. Ganten D. Ferrario C.M. Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene American Journal of Physiology - Regulatory Integrative and Comparative Physiology 1994 266 4 35-4 R1273-R1279 15. Moriguchi A, Brosnihan KB, Kumagai H, Ganten D, Ferrario CM. Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene. Am J Physiol Regul Integr Comp Physiol 266: R1273-R1279, 1994. (Pubitemid 24149481)
16. Moriguchi A, Tallant EA, Matsumura K, Reilly TM, Walton H, Ganten D, Ferrario CM. Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats. Hypertension 25: 1260-1265, 1995.
17. Muller S. Zhao Y. Brown T.L. Morgan A.C. Kohler H. TransMabs: Cell-penetrating antibodies, the next generation Expert Opinion on Biological Therapy 2005 5 2 237-241 DOI 10.1517/14712598.5.2.237 17. Muller S, Zhao Y, Brown TL, Morgan AC, Kohler H. TransMabs: cell-penetrating antibodies, the next generation. Expert Opin Biol Ther 5: 237-241, 2005. (Pubitemid 40388853)
18. Nagata S. Kato J. Sasaki K. Minamino N. Eto T. Kitamura K. Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system Biochemical and Biophysical Research Communications 2006 350 4 1026-1031 DOI 10.1016/j.bbrc.2006.09.146, PII S0006291X06022030 18. Nagata S, Kato J, Sasaki K, Minamino N, Eto T, Kitamura K. Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system. Biochem Biophys Res Commun 350: 1026-1031, 2006. (Pubitemid 44596223)
19. Nakamura S. Averill D.B. Chappell M.C. Diz D.I. Brosnihan K.B. Ferrario C.M. Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR American Journal of Physiology - Regulatory Integrative and Comparative Physiology 2003 284 1 53-1 R164-R173 19. Nakamura S, Averill DB, Chappell MC, Diz DI, Brosnihan KB, Ferrario CM. Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR. Am J Physiol Regul Integr Comp Physiol 284: R164-R173, 2003. (Pubitemid 36008667)
20. Phillips M.I. Speakman E.A. Kimura B. Levels of angiotensin and molecular biology of the tissue renin angiotensin systems Regulatory Peptides 1993 43 1 2 1-20 DOI 10.1016/0167-0115(93)90403-U 20. Phillips MI, Speakman EA, Kimura B. Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Regul Pept 43: 1-20, 1993. (Pubitemid 23018639)
21. Prosser HC, Forster ME, Richards AM, Pemberton CJ. Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics. Cardiovasc Res 82: 40-50, 2009.
22. Sakai K. Agassandian K. Morimoto S. Sinnayah P. Cassell M.D. Davisson R.L. Sigmund C.D. Local production of angiotensin II in the subfornical organ causes elevated drinking Journal of Clinical Investigation 2007 117 4 1088-1095 http://www.jci.org/cgi/reprint/117/4/1088 DOI 10.1172/JCI31242 22. Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD. Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest 117: 1088-1095, 2007. (Pubitemid 46556765)
23. Des Senanayake P. Moriguchi A. Kumagai H. Gantent D. Ferrario C.M. Brosnihan K.B. Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats Peptides 1994 15 5 919-926 DOI 10.1016/0196- 9781(94)90051-5 23. Senanayake PD, Moriguchi A, Kumagai H, Ganten D, Ferrario CM, Brosnihan KB. Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats. Peptides 15: 919-926, 1994. (Pubitemid 24248417)
24. Trask AJ, Jessup JA, Chappell MC, Ferrario CM. Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol Heart Circ Physiol 294: H2242-H2247, 2008.
25. Veerasingham S.J. Raizada M.K. Brain renin-angiotensin system dysfunction in hypertension: Recent advances and perspectives British Journal of Pharmacology 2003 139 2 191-202 DOI 10.1038/sj.bjp.0705262 25. Veerasingham SJ, Raizada MK. Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br J Pharmacol 139: 191-202, 2003. (Pubitemid 36760351)
26. Von Bohlen Und Halbach O. Albrecht D. The CNS renin-angiotensin system Cell and Tissue Research 2006 326 2 599-616 DOI 10.1007/s00441-006-0190-8 26. von Bohlen HO, Albrecht D. The CNS renin-angiotensin system. Cell Tissue Res 326: 599-616, 2006. (Pubitemid 44435828)