Protective effect of α-lipoic acid on oxidized low density lipoprotein-induced human umbilical vein endothelial cell injury

Pharmacological Reports

Volumn 63, Issue 5, 2011, Pages 1180-1188

  Liu, Yan Xia ^a   Han, Guo Zhu ^a   Wu, Tao ^a   Liu, Peng ^a   Zhou, Qin ^a   Liu, Ke Xin ^a   Sun, Hui Jun ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; HUVEC; Oxidized low density lipoprotein; lipoic acid

Indexed keywords

C REACTIVE PROTEIN; CERAMIDE; LACTATE DEHYDROGENASE; LIPOCORTIN 5; MALONALDEHYDE; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN BCL 2; THIOCTIC ACID;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL SURFACE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; TANDEM MASS SPECTROMETRY; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

EID: 83155181923     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(11)70637-5     Document Type: Article

References (30)

1. Aviram M, Vaya J: Markers for low-density lipoprotein oxidation. Methods Enzymol, 2001, 335, 244-256. (Pubitemid 32507242)
2. Berliner JA, Heinecke JW: The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med, 1996, 20, 707-727. (Pubitemid 26105783)
3. Biffl WL, Moore EE, Moore FA, Barnett C: Nitric oxide reduces endothelial expression of intercellular adhesion molecule (ICAM-1). J Surg Res, 1996, 63, 328.
4. Boots AW, Haenen GR, Bast A: Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol, 2008, 585, 325-337.
5. Buttke TM, Sandstrom PA: Oxidative stress as a mediator of apoptosis. Immunol Today, 1994, 15, 7-10.
6. Carreau JP: Biosynthesis of lipoic acid via unsaturated fatty acids. Methods Enzymol, 1979, 62, 152-158.
7. Chen J, Mehta JL, Haider N, Zhang X, Narula J, Li D: Role of caspases in ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells. Circ Res, 2004, 94, 370-376. (Pubitemid 38240729)
8. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS et al.: Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood, 1998, 91, 3527-3561. (Pubitemid 28225719)
9. Cominacini L, Pasini AF, Garbin U, Davoli A, Tosetti ML, Campagnola M, Rigoni A et al.: Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species. J Biol Chem, 2000, 275, 12633-12638. (Pubitemid 30241412)
10. Escargueil-Blanc I, Meilhac O, Pieraggi M-T, Arnal J-F, Salvayre R, Negre-Salvayre A: Oxidized LDLs induce massive apoptosis of cultured human endothelial cells through a calcium-dependent pathway. Prevention by aurintricarboxylic acid. Arterioscler Thromb Vasc Biol, 1997, 17, 331-339. (Pubitemid 27098192)
11. Hannun YA, Luberto C: Ceramide in the eukaryotic stress response. Trends Cell Biol, 2000, 10, 73-78.
12. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 1993;75, 241-251. (Pubitemid 23320288)
13. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T et al.: Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science, 1993, 262, 1274-1277. (Pubitemid 24036095)
14. Karsan A, Harlan JM: Modulation of endothelial cell apoptosis: mechanisms and pathophysiological roles. J Atheroscler Thromb, 1996, 3, 75-80.
15. Kondo S, Yin D, Aoki T, Takahashi JA, Morimura T, Takeuchi J: Bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp Cell Res, 1994, 213, 428-32. (Pubitemid 24259489)
16. Kume N, Kita T: Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture. Circ Res, 2004, 94, 269-70. (Pubitemid 38240716)
17. Li D, Mehta JL: Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation, 2000, 101, 2889-2895. (Pubitemid 30415877)
18. Li JM, Shah AM: Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol, 2004, 287, R1014-1030.
19. Liuzzo G, Giubilato G, Pinnelli M: T cells and cytokines in atherogenesis. Lupus, 2005, 14, 732-735. (Pubitemid 41413301)
20. Marangon K, Devaraj S, Tirosh O, Packer L, Jialal I: Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress. Free Radic Biol Med, 1999, 27, 1114-1121. (Pubitemid 29507484)
21. Moini H, Packer L, Saris NE: Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol, 2002, 182, 84-90. (Pubitemid 34775480)
22. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods, 1983, 65, 55-63.
23. Packer L, Witt EC, Tritschler HJ: Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med, 1995, 19, 227-250.
24. Ross R: Atherosclerosis-an inflammatory disease. New Engl J Med, 1999, 340, 115-126.
25. Ross R: The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature, 1993, 362, 801-809.
26. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T et al.: An endothelial receptor for oxidized low-density lipoprotein. Nature, 1997, 386, 73-77. (Pubitemid 27130922)
27. Steinberg D: Lewis A. Conner Memorial Lecture: Oxidative modification of LDL and atherogenesis. Circulation, 1997, 95, 1062-1071.
28. Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S et al.: C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance. Am J Pathol, 2005, 167, 1139-1148. (Pubitemid 41416264)
29. Taye A, Sawamura T, Morawietz H: Aldosterone augments LOX-1-mediated low-density lipoprotein uptake in human umbilical artery endothelial cells. Pharmacol Rep, 2010, 62, 311-318.
30. Wang CB, Feng YM, Zong YQ, Deng YZ, Feng ZC: Rapid isolation of large amount of plasma VLDL and LDL by a two step ultracentrifugation. J Tongji Med Univ, 1995, 15, 198-200.