Rickettsia conorii infection stimulates the expression of ISG15 and ISG15 protease UBP43 in human microvascular endothelial cells

Biochemical and Biophysical Research Communications

Volumn 416, Issue 1-2, 2011, Pages 153-158

  Colonne, Punsiri M ^a   Sahni, Abha ^b   Sahni, Sanjeev K ^b,c  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Endothelial cells; Interferon; ISG15; Rickettsia conorii; UBP43

Indexed keywords

BETA INTERFERON; INTERFERON; PROTEIN ISG15; PROTEINASE; TETRACYCLINE; UBP43 ENZYME; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; BOUTONNEUSE FEVER; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MICROVASCULAR ENDOTHELIAL CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RICKETTSIA CONORII; RNA INTERFERENCE;

AUTOCRINE COMMUNICATION; BOUTONNEUSE FEVER; CELLS, CULTURED; CYTOKINES; ENDOPEPTIDASES; ENDOTHELIUM, VASCULAR; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERFERON-BETA; MICROVESSELS; RICKETTSIA CONORII; RNA, MESSENGER; RNA, SMALL INTERFERING; UBIQUITINS;

BACTERIA (MICROORGANISMS); MAMMALIA; RICKETTSIA CONORII; RICKETTSIACEAE;

EID: 83055182202     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.11.015     Document Type: Article

References (27)

1. Leroy Q., Raoult D. Mediterranean spotted fever. Infect. Dis. Clin. North Am. 2008, 22:515-530.
2. Sousa R., França A., Dória Nòbrega S., Belo A., Amaro M., Abreu T., Poças J., Proença P., Vaz J., Torgal J., Bacellar F., Ismail N., Walker D.H. Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients. J. Infect. Dis. 2008, 198:576-585.
3. Nicholson W.L., Allen K.E., McQuiston J.H., Breitschwerdt E.B., Little S.E. The increasing recognition of rickettsial pathogens in dogs and people. Trends Parasitol. 2010, 26:205-212.
4. Shah S.S., McGowan J.P. Rickettsial, ehrlichial and Bartonella infections of the myocardium and pericardium. Front. Biosci. 2003, 8:e197-e201.
5. Rombola F. Mediterranean spotted fever presenting as an acute pancreatitis. Acta Gastroenterol. Belg. 2011, 74:91-92.
6. Aliaga L., Sánchez-Blázquez P., Rodríguez-Granger J., Sampedro A., Orozco M., Pastor J. Mediterranean spotted fever with encephalitis. J. Med. Microbiol. 2009, 58:521-525.
7. Sahni S.K. Endothelial cell infection and hemostasis. Thromb. Res. 2007, 119:531-549.
8. Valbuena G., Walker D.H. Infection of the endothelium by members of the order Rickettsiales. Thromb. Haemost. 2009, 102:1071-1079.
9. Colonne P.M., Eremeeva M.E., Sahni S.K. Beta interferon-mediated activation of signal transducer and activator of transcription protein 1 interferes with Rickettsia conorii replication in human endothelial cells. Infect. Immun. 2011, 79:3733-3743.
10. D'Cunha J., Knight E., Haas A.L., Truitt R.L., Borden E.C. Immunoregulatory properties of ISG15, an interferon-induced cytokine. Proc. Natl. Acad. Sci. USA 1996, 93:211-215.
11. Rydkina E., Sahni S.K., Santucci L.A., Turpin L.C., Baggs R.B., Silverman D.J. Selective modulation of antioxidant enzyme activities in host tissues during Rickettsia conorii infection. Microb. Pathog. 2004, 36:293-301.
12. Sahni S.K., Kiriakidi S., Colonne P.M., Sahni A., Silverman D.J. Selective activation of signal transducer and activator of transcription (STAT) proteins STAT1 and STAT3 in human endothelial cells infected with Rickettsia rickettsii. Clin. Microbiol. Infect. 2009, 15:303-304.
13. Eremeeva M.E., Dasch G.A., Silverman D.J. Evaluation of a PCR assay for quantitation of Rickettsia rickettsii and closely related spotted fever group rickettsiae. J. Clin. Microbiol. 2003, 41:5466-5472.
14. Zuniga E.I., Hahm B., Oldstone M.B. Type I interferon during viral infections: multiple triggers for a multifunctional mediator. Curr. Top. Microbiol. Immunol. 2007, 316(9):337-357.
15. Kim K.I., Zhang D.E. ISG15, not just another ubiquitin-like protein. Biochem. Biophys. Res. Commun. 2003, 307:431-434.
16. Turco J., Winkler H.H. Interferon-alpha/beta and Rickettsia prowazekii: induction and sensitivity. Ann. NY Acad. Sci. 1990, 590:168-186.
17. Okumura A., Lu G., Pitha-Rowe I., Pitha P.M. Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15. Proc. Natl. Acad. Sci. USA 2006, 103:1440-1445.
18. Okumura A., Pitha P.M., Harty RN R.N. ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc. Natl. Acad. Sci USA 2008, 105:3974-3979.
19. Skaug B., Chen Z.J. Emerging role of ISG15 in antiviral immunity. Cell 2010, 143:187-190.
20. Zhao C., Hsiang T.Y., Kuo R.L., Krug R.M. ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. Proc. Natl. Acad. Sci. USA 2010, 107:2253-2258.
21. Jeon Y.J., Yoo H.M., Chung C.H. ISG15 and immune diseases. Biochim. Biophys. Acta 2010, 1802:485-496.
22. Ritchie K.J., Hahn C.S., Kim K.I., Yan M., Rosario D., Li L., de la Torre J.C., Zhang D.E. Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat. Med. 2004, 10:1374-1378.
23. Kim J.H., Luo J.K., Zhang D.E. The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression. J. Immunol. 2008, 181:6467-6472.
24. Malakhova O., Malakhov M., Hetherington C., Zhang D.E. Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3. J. Biol. Chem. 2002, 277:14703-14711.
25. Kim K.I., Malakhova O.A., Hoebe K., Yan M., Beutler B., Zhang D.E. Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling. J. Immunol. 2005, 175:847-854.
26. Hackstadt T. The biology of rickettsiae. Infect. Agents Dis. 1996, 5:127-143.
27. Malakhova O., Kim K., Luo J., Zou W., Kumar K.S., Fuchs S.Y., Shuai K., Zhang D.E. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J. 2006, 25:2358-2367.