Regulation and Differential Role of the Tissue Factor Isoforms in Cardiovascular Biology

Trends in Cardiovascular Medicine

Volumn 20, Issue 6, 2010, Pages 199-203

  Eisenreich, Andreas ^a   Rauch, Ursula ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; CYCLIN DEPENDENT KINASE; DNA TOPOISOMERASE; MESSENGER RNA PRECURSOR; PROTEIN KINASE B; SERINE ARGININE RICH PROTEIN; THROMBOPLASTIN;

ANGIOGENESIS; BLOOD CLOTTING; BLOOD VESSEL WALL; CELL PROLIFERATION; CELL SURVIVAL; CONGESTIVE CARDIOMYOPATHY; HEART MUSCLE; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; RNA SPLICING; SIGNAL TRANSDUCTION; SURVIVAL; THROMBOGENICITY; UPREGULATION; VASCULAR BIOLOGY;

ALTERNATIVE SPLICING; BLOOD COAGULATION; CARDIOVASCULAR DISEASES; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; HUMANS; PROTEIN ISOFORMS; PROTEOMICS; RNA PRECURSORS; THROMBOPLASTIN;

EID: 83055179061     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2011.08.001     Document Type: Review

References (41)

1. Abraham E., Reinhart K., Opal S., et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial. JAMA 2003, 290:238-247.
2. Ahamed J., Versteeg H.H., Kerver M., et al. Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci USA 2006, 103:13932-13937.
3. Antoniak S., Boltzen U., Eisenreich A., et al. Regulation of cardiomyocyte full-length tissue factor expression and microparticle release under inflammatory conditions in vitro. J Thromb Haemost 2009, 7:871-878.
4. Bogdanov V.Y., Balasubramanian V., Hathcock J., et al. Alternatively spliced human tissue factor: A circulating, soluble, thrombogenic protein. Nat Med 2003, 9:458-462.
5. Cavusoglu E., Chen I., Rappaport J., Marmur J.D. Inhibition of tissue factor gene induction and activity using a hairpin ribozyme. Circulation 2002, 105:2282-2287.
6. Censarek P., Bobbe A., Grandoch M., et al. Alternatively spliced human tissue factor (asHTF) is not pro-coagulant. Thromb Haemost 2007, 97:11-14.
7. Chand H.S., Ness S.A., Kisiel W. Identification of a novel human tissue factor splice variant that is upregulated in tumor cells. Int J Cancer 2006, 118:1713-1720.
8. Chandradas S., Deikus G., Tardos J.G., Bogdanov V.Y. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. J Leukoc Biol 2010, 87:147-152.
9. Chesebro J.H., Rauch U., Fuster V., Badimon J.J. Pathogenesis of thrombosis in coronary artery disease. Haemostasis 1997, 27(Suppl 1):12-18.
10. Eisenreich A., Bogdanov V.Y., Zakrzewicz A., et al. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Circ Res 2009, 104:589-599.
11. Eisenreich A., Boltzen U., Malz R., et al. Overexpression of alternatively spliced tissue factor induces the pro-angiogenic properties of murine cardiomyocytic HL-1 cells. Circ J 2011, 75:1235-1242.
12. Eisenreich A., Boltzen U., Poller W., et al. Effects of the Cdc2-like kinase-family and DNA topoisomerase I on the alternative splicing of eNOS in TNF-alpha-stimulated human endothelial cells. Biol Chem 2008, 389:1333-1338.
13. Eisenreich A., Celebi O., Goldin-Lang P., et al. Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel. Int Immunopharmacol 2008, 8:307-311.
14. Eisenreich A., Malz R., Pepke W., et al. Role of the phosphatidylinositol 3-kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells. Circ J 2009, 73:1746-1752.
15. Eisenreich A., Rauch U. PI3K inhibitors in cardiovascular disease. Cardiovasc Ther 2011, 29:29-36.
16. Fedorov O., Huber K., Eisenreich A., et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol 2011, 18:67-76.
17. Giesen P.L., Rauch U., Bohrmann B., et al. Blood-borne tissue factor: Another view of thrombosis. Proc Natl Acad Sci USA 1999, 96:2311-2315.
18. Goldin-Lang P., Tran Q.V., Fichtner I., et al. Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumor metastasis. Oncol Rep 2008, 20:123-128.
19. Hagiwara M. Alternative splicing: A new drug target of the post-genome era. Biochim Biophys Acta 2005, 1754:324-331.
20. Hedner U., Ezban M. Tissue factor and factor VIIa as therapeutic targets in disorders of hemostasis. Annu Rev Med 2008, 59:29-41.
21. Hobbs J.E., Zakarija A., Cundiff D.L., et al. Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Thromb Res 2007, 120(Suppl 2):S13-S21.
22. Ishii H., Takada K., Higuchi T., Sugiyama J. Verotoxin-1 induces tissue factor expression in human umbilical vein endothelial cells through activation of NF-kappaB/Rel and AP-1. Thromb Haemost 2000, 84:712-721.
23. Mackman N. Regulation of the tissue factor gene. Thromb Haemost 1997, 78:747-754.
24. Mackman N. Alternatively spliced tissue factor: One cut too many?. Thromb Haemost 2007, 97:5-8.
25. Morrow D.A., Murphy S.A., McCabe C.H., et al. Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): Results of the PROXIMATE-TIMI 27 trial. Eur Heart J 2005, 26:682-688.
26. Nakagawa K., Zhang Y., Tsuji H., et al. The angiogenic effect of tissue factor on tumors and wounds. Semin Thromb Hemost 1998, 24:207-210.
27. Pawlinski R., Tencati M., Holscher T., et al. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost 2007, 5:1693-1700.
28. Rauch U., Bonderman D., Bohrmann B., et al. Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood 2000, 96:170-175.
29. Rauch U., Nemerson Y. Tissue factor, the blood, and the arterial wall. Trends Cardiovasc Med 2000, 10:139-143.
30. Rauch U., Nemerson Y. Circulating tissue factor and thrombosis. Curr Opin Hematol 2000, 7:273-277.
31. Rother M., Krohn S., Kania G., et al. Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator. Circulation 2010, 122:2688-2698.
32. Schwertz H., Tolley N.D., Foulks J.M., et al. Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 2006, 203:2433-2440.
33. Steffel J., Lüscher T.F., Tanner F.C. Tissue factor in cardiovascular diseases: Molecular mechanisms and clinical implications. Circulation 2006, 113:722-731.
34. Szotowski B., Antoniak S., Poller W., et al. Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines. Circ Res 2005, 96:1233-1239.
35. Szotowski B., Antoniak S., Rauch U. Alternatively spliced tissue factor: A previously unknown piece in the puzzle of hemostasis. Trends Cardiovasc Med 2006, 16:177-182.
36. Tardos J.G., Eisenreich A., Deikus G., et al. SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost 2008, 6:877-884.
37. van den Berg Y.W., van den Hengel L.G., Myers H.R., et al. Alternatively spliced tissue factor induces angiogenesis through integrin ligation. Proc Natl Acad Sci USA 2009, 106:19497-19502.
38. Versteeg H.H., Schaffner F., Kerver M., et al. Inhibition of tissue factor signaling suppresses tumor growth. Blood 2008, 111:190-199.
39. Vincent J.L., Artigas A., Petersen L.C., Meyer C. A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome. Crit Care Med 2009, 37:1874-1880.
40. Yu J.L., Rak J.W. Shedding of tissue factor (TF)-containing microparticles rather than alternatively spliced TF is the main source of TF activity released from human cancer cells. J Thromb Haemost 2004, 2:2065-2067.
41. Zhang X., Yu H., Lou J.R., et al. MicroRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem 2011, 286:1429-1435.