Alternatively spliced tissue factor induces angiogenesis through integrin ligation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 46, 2009, Pages 19497-19502

  Van Den Berg, Y W ^a   Van Den Hengel, L G ^a   Myers, H R ^a   Ayachi, O ^a   Jordanova, E ^a   Ruf, W ^b   Spek, C A ^c   Reitsma, P H ^a   Bogdanov, V Y ^d   Versteeg, H H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cancer; Coagulation; Endothelial cells; Integrins

Indexed keywords

ANTIBODY; BETA1 INTEGRIN; BETA3 INTEGRIN; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; HIRUDIN; INTEGRIN; MATRIGEL; PROTEINASE ACTIVATED RECEPTOR 2; THROMBOPLASTIN; THROMBOPLASTIN ANTIBODY; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 6; VITRONECTIN RECEPTOR; BLOOD CLOTTING FACTOR 5;

ALTERNATIVE RNA SPLICING; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR SPACE; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR RING; ANIMAL; AORTA; C57BL MOUSE; CAPILLARY; CELL MOTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); VASCULAR ENDOTHELIUM;

MUS;

ALTERNATIVE SPLICING; ANIMALS; AORTA; CAPILLARIES; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; FACTOR V; INTEGRIN ALPHA6BETA1; INTEGRIN ALPHAVBETA3; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR, PAR-2; THROMBOPLASTIN;

EID: 73349128473     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905325106     Document Type: Article

References (27)

1. Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438:932-936.
2. Holderfield MT, Hughes CC (2008) Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res 102:637-652.
3. Rundhaug JE (2005) Matrix metalloproteinases and angiogenesis. J Cell Mol Med 9:267-285.
4. Li A, Dubey S, Varney ML, Dave BJ, Singh RK (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170:3369-3376.
5. Brooks PC, Clark RA, Cheresh DA (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264:569-571.
6. Bloch W, et al. (1997) Beta 1 integrin is essential for teratoma growth and angiogenesis. J Cell Biol 139:265-278.
7. Versteeg HH, Ruf W (2006) Emerging insights in tissue factor-dependent signaling events. Semin Thromb Hemost 32:24-32.
8. Carmeliet P, et al. (1996) Role of tissue factor in embryonic blood vessel development. Nature 383:73-75.
9. Yu JL, et al. (2005) Oncogenic events regulate tissue factor expression in colorectal cancer cells: Implications for tumor progression and angiogenesis. Blood 105:1734-1741.
10. Versteeg HH, et al. (2008) Inhibition of tissue factor signaling suppresses tumor growth. Blood 111:190-199.
11. Versteeg HH, et al. (2008) Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Res 68:7219-7227.
12. Milsom CC, et al. (2008) Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: Effect on tumor initiation and angiogenesis. Cancer Res 68:10068-10076.
13. Zhang JQ, et al. (2008) The FVIIa-tissue factor complex induces the expression of MMP7 in LOVO cells in vitro. Int J Colorectal Dis 23:971-978.
14. Dorfleutner A, Hintermann E, Tarui T, Takada Y, Ruf W (2004) Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. Mol Biol Cell 15:4416-4425.
15. Bogdanov VY, et al. (2003) Alternatively spliced human tissue factor: A circulating, soluble, thrombogenic protein. Nat Med 9:458-462.
16. Censarek P, Bobbe A, Grandoch M, Schror K, Weber AA (2007) Alternatively spliced human tissue factor (asHTF) is not pro-coagulant. Thromb Haemost 97:11-14.
17. Szotowski B, Antoniak S, Rauch U (2006) Alternatively spliced tissue factor: A previously unknown piece in the puzzle of hemostasis. Trends Cardiovasc Med 16:177-182.
18. Haas SL, et al. (2006) Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation. World J Gastroenterol 12:4843-4849.
19. Goldin-Lang P, et al. (2008) Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumor metastasis. Oncol Rep 20:123-128.
20. Hobbs JE, et al. (2007) Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Thromb Res 120 Suppl 2:S13-S21.
21. Masson V, et al. (2002) Mouse aortic ring assay: A new approach of the molecular genetics of angiogenesis. Biol Proced Online 4:24-31.
22. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433.
23. Kuzuya M, et al. (1999) Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice. Exp Cell Res 248:498-508.
24. Von Offenberg SN, et al. (2005) Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation. Biochem Biophys Res Commun 329:573-582.
25. Danen EH, Sonneveld P, Brakebusch C, Fassler R, Sonnenberg A (2002) The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol 159:1071-1086.
26. Clark RA, Tonnesen MG, Gailit J, Cheresh DA (1996) Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Am J Pathol 148:1407-1421.
27. Rauch U, et al. (2005) Association of tissue-factor upregulation in squamous-cell carcinoma of the lung with increased tissue factor in circulating blood. Lancet Oncol 6:254.