Elevated plasma gas6 levels are associated with venous thromboembolic disease

Journal of Thrombosis and Thrombolysis

Volumn 32, Issue 3, 2011, Pages 272-278

  Blostein, Mark D ^a   Rajotte, Isabelle ^a   Rao, Deepa P ^a   Holcroft, Christina A ^a   Kahn, Susan R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Gas6; Venous thromboembolic disease

Indexed keywords

GROWTH ARREST SPECIFIC PROTEIN 6;

ADULT; AGE DISTRIBUTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; MOLECULAR PATHOLOGY; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RISK ASSESSMENT; RISK FACTOR; TREND STUDY; VENOUS THROMBOEMBOLISM;

ADULT; AGED; ANIMALS; BIOLOGICAL MARKERS; COHORT STUDIES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MIDDLE AGED; RISK FACTORS; VENOUS THROMBOEMBOLISM;

EID: 82955249066     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-011-0597-2     Document Type: Article

References (32)

1. Manfioletti G, Brancolini C, Avanzi G, Schneider C (1993) The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol 13:4976-4985 (Pubitemid 23220402)
2. Angelillo-Scherrer A, de Frutos P, Aparicio C, Melis E, Savi P, Lupu F, Arnout J, Dewerchin M, Hoylaerts M, Herbert J, Collen D, Dahlback B, Carmeliet P (2001) Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med 7:215-221 (Pubitemid 32148489)
3. Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Vesin C, Hoylaerts MF, Plaisance S, Collen D, Conway EM, Wehrle-Haller B, Carmeliet P (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115:237-246 (Pubitemid 40385466)
4. Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158:585-593 (Pubitemid 28144815)
5. Kahn SR, Ginsberg JS (2002) The post-thrombotic syndrome: current knowledge, controversies, and directions for future research. Blood Rev 16:155-165 (Pubitemid 34982972)
6. Becattini C, Agnelli G, Pesavento R, Silingardi M, Poggio R, Taliani MR, Ageno W (2006) Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest 130:172-175. doi:130/1/172[pii]10. 1378/chest.130.1.172 (Pubitemid 44116856)
7. Franchini M, Veneri D, Salvagno GL, Manzato F, Lippi G (2006) Inherited thrombophilia. Crit Rev Clin Lab Sci 43:249-290
8. Ageno W, Squizzato A, Garcia D, Imberti D (2006) Epidemiology and risk factors of venous thromboembolism. Semin Thromb Hemost 32:651-658 (Pubitemid 44623373)
9. Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd (2000) Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 160:809-815 (Pubitemid 30165241)
10. Virchow R (1856) Gesammalte abhandlungen zur wissenschaftichen medtzin. Medinger Sohn & Co, Frankfurt
11. Balogh I, Hafizi S, Stenhoff J, Hansson KBD (2005) Analysis of Gas6 in human platelets and plasma. Arterioscler Thromb Vasc Biol 25:1280-1286 (Pubitemid 40776622)
12. Kahn SR, Shrier I, Julian JA, Ducruet T, Arsenault L, Miron MJ, Roussin A, Desmarais S, Joyal F, Kassis J, Solymoss S, Desjardins L, Lamping DL, Johri M, Ginsberg JS (2008) Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med 149:698-707
13. Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA (2005) Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. J Thromb Haemost 3:733-741 (Pubitemid 41647888)
14. Hansson PO, Welin L, Tibblin G, Eriksson H (1997) Deep vein thrombosis and pulmonary embolism in the general population. 'The Study of Men Born in 1913'. Arch Intern Med 157:1665-1670 (Pubitemid 27327401)
15. Prandoni P, Bilora F, Marchiori A, Bernardi E, Petrobelli F, Lensing AW, Prins MH, Girolami A (2003) An association between atherosclerosis and venous thrombosis. N Engl J Med 348:1435-1441 (Pubitemid 36407172)
16. Prandoni P, Ghirarduzzi A, Prins MH, Pengo V, Davidson BL, Sorensen H, Pesavento R, Iotti M, Casiglia E, Iliceto S, Pagnan A, Lensing AW (2006) Venous thromboembolism and the risk of subsequent symptomatic atherosclerosis. J Thromb Haemost 4:1891-1896 (Pubitemid 44226764)
17. Martinelli I, Battaglioli T, Razzari C, Mannucci PM (2007) Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia. J Thromb Haemost 5:98-101 (Pubitemid 44921073)
18. De Stefano V, Finazzi G, Mannucci PM (1996) Inherited thrombophilia: pathogenesis, clinical syndromes, and management. Blood 87:3531-3544 (Pubitemid 26129579)
19. Shattil SJ, Kashiwagi H, Pampori N (1998) Integrin signaling: the platelet paradigm. Blood 91:2645-2657 (Pubitemid 28227512)
20. Hasanbasic I, Cuerquis J, Varnum B, Blostein M (2004) Intracellular signalling pathways involved in gas6-Axl mediated survival of endothelial cells. Am J Physiol 287:H1207-H1213 (Pubitemid 39096668)
21. Hasanbasic I, Rajotte I, Blostein M (2005) The role of g-carboxylation in the anti-apoptotic effect of gas6 in endothelium. Journal of Thrombosis and Hemostasis. 3:2790-2797 (Pubitemid 41819809)
22. Healy AM, Schwartz JJ, Zhu X, Herrick BE, Varnum B, Farber HW (2001) Gas 6 promotes Axl-mediated survival in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 280: L1273-L1281
23. Alciato F, Sainaghi PP, Castello L, Bergamasco L, Carnieletto S, Avanzi GC (2008) Development and validation of an ELISA method for detection of growth arrest specific 6 (GAS6) protein in human plasma. J Immunoassay Immunochem 10:1080
24. Clauser S, Peyrard S, Gaussem P, Crespin M, Emmerich J, Aiach M, Borgel D (2007) Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status. Clin Chem 53:1808-1813 (Pubitemid 47509674)
25. Gibot S, Massin F, Cravoisy A, Dupays R, Barraud D, Nace L, Bollaert PE (2007) Growth arrest-specific protein 6 plasma concentrations during septic shock. Crit Care. 11:R8
26. Sainaghi PP, Alciato F, Carnieletto S, Castello L, Bergamasco L, Sola D, Bongo AS, Inglese E, Polosa R, Avanzi GC (2009) Gas6 evaluation in patients with acute dyspnea due to suspected pulmonary embolism. Respir Med 103:589-594
27. Uehara S, Handa H, Gotoh K, Tomita H, Sennshuu M (2009) Plasma concentrations of growth arrest-specific protein 6 and protein S in patients with acute pancreatitis. J Gastroenterol Hepatol 24:1567-1573
28. Hirsh J (1991) Oral anticoagulant drugs. N Engl J Med 324:1865-1875
29. Borgel D, Clauser S, Bornstain C, Bieche I, Bissery A, Remones V, Fagon JY, Aiach M, Diehl JL (2006) Elevated growth-arrestspecific protein 6 plasma levels in patients with severe sepsis. Crit Care Med 34:219-222 (Pubitemid 43032400)
30. Clauser S, Bachelot-Lozat C, Fontana P, Gaussem P, Remones V, Aiach M, Borgel D (2006) Physiological plasma Gas6 levels do not influence platelet aggregation. Arterioscler Thromb Vasc Biol 26:e22
31. Burnier L, Borgel D, Angelillo-Scherrer A, Fontana P (2006) Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects. J Thromb Haemost 4:2283-2284 (Pubitemid 44400314)
32. Kearon C (2003) Natural history of venous thromboembolism. Circulation. 107:I22-I30 (Pubitemid 41289268)