Gas6 evaluation in patients with acute dyspnea due to suspected pulmonary embolism

Respiratory Medicine

Volumn 103, Issue 4, 2009, Pages 589-594

  Sainaghi, Pier Paolo ^a   Alciato, Federica ^a   Carnieletto, Stefania ^a   Castello, Luigi ^a   Bergamasco, Luca ^a   Sola, Daniele ^a   Bongo, Angelo Sante ^b   Inglese, Eugenio ^a   Polosa, Riccardo ^c   Avanzi, Gian Carlo ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

^c UOC Dermatology   (Italy)

Author keywords

Acute dyspnea; Gas6; Pulmonary embolism; Pulmonary infections

Indexed keywords

GROWTH ARREST SPECIFIC PROTEIN 6; MACROSALB TC 99M; BIOLOGICAL MARKER; CREATININE; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D; GROWTH ARREST-SPECIFIC PROTEIN 6; SIGNAL PEPTIDE;

ACUTE DISEASE; ADULT; AGED; ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIFFERENTIAL DIAGNOSIS; DYSPNEA; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART FAILURE; HUMAN; LUNG CANCER; LUNG EMBOLISM; LUNG INFECTION; LUNG SCINTISCANNING; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; COMPLICATION; MIDDLE AGED; PROCEDURES; PULMONARY EMBOLISM; RESPIRATORY TRACT INFECTIONS; SCINTIGRAPHY; SENSITIVITY AND SPECIFICITY; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CREATININE; DIAGNOSIS, DIFFERENTIAL; DYSPNEA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HEART FAILURE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MIDDLE AGED; PERFUSION IMAGING; PULMONARY EMBOLISM; RESPIRATORY TRACT INFECTIONS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, SPIRAL COMPUTED;

EID: 60649113647     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2008.10.018     Document Type: Article

References (29)

1. Christ M., Laule K., Klima T., et al. Multimarker strategy for risk prediction in patients presenting with acute dyspnea to the emergency department. Int J Cardiol 126 (2008) 73-78
2. Stein P.D., Woodard P.K., Weg J.G., et al. PIOPED II investigators. PIOPED II investigators. Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators. Am J Med 119 (2006) 1048-1055
3. Joseph D.R. Sequence and functional relationships between androgen-binding protein/sex hormone-binding globulin and its homologs protein S, Gas6, laminin, and agrin. Steroids 62 (1997) 578-588
4. Manfioletti G., Brancolini C., Avanzi G., and Schneider C. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol 13 (1993) 4976-4985
5. Godowski P.J., Mark M.R., Chen J., Sadick M.D., Raab H., and Hammonds R.G. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. Cell 82 (1995) 355-358
6. Varnum B.C., Young C., Elliott G., et al. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature 373 (1995) 623-626
7. Nagata K., Ohashi K., Nakano T., et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem 271 (1996) 30022-30027
8. Chen J., Carey K., and Godowski P.J. Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation. Oncogene 14 (1997) 2033-2039
9. Graham D.K., Dawson T.L., Mullaney D.L., Snodgrass H.R., and Earp H.S. Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ 5 (1994) 647-657
10. Avanzi G.C., Gallicchio M., Bottarel F., et al. GAS6 inhibits granulocyte adhesion to endothelial cells. Blood 91 (1998) 2334-2340
11. Prieto A.L., Weber J.L., Tracy S., Heeb M.J., and Gas6 L.C. a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system. Brain Res 816 (1999) 646-661
12. Angelillo-Scherrer A., de Frutos P., Aparicio C., et al. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med 7 (2001) 215-221
13. Angelillo-Scherrer A., Burnier L., Flores N., et al. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115 (2005) 237-246
14. Lu Q., and Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293 (2001) 306-311
15. Lemke G., and Lu Q. Macrophage regulation by Tyro 3 family receptors. Curr Opin Immunol 15 (2003) 31-36
16. Borgel D., Clauser S., Bornstain C., et al. Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis. Crit Care Med 34 (2006) 219-222
17. Gibot S., Massin F., Cravoisy A., et al. Growth arrest-specific protein 6 plasma concentrations during septic shock. Crit Care 11 (2007) R8
18. Wicki J., Perneger T.V., Junod A.F., Bounameaux H., and Perrier A. Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score. Arch Intern Med 161 (2001) 92-97
19. Food and Drug Administration, U.S. Department of Health and Human Services, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). Guidance for Industry: Bioanalytical Method Validation 2001; 1-20. www.fda.gov/cder/guidance/index.htm.
20. Alciato F., Sainaghi P.P., Castello L., Bergamasco L., Carnieletto S., and Avanzi G.C. Development and validation of an ELISA method for detection of growth arrest specific 6 (Gas6) protein in human plasma. J Immunoassay Immunochem 29 (2008) 167-180
21. Balogh I., Hafizi S., Stenhoff J., Hansson K., and Dahlbäck B. Analysis of Gas6 in human platelets and plasma. Arterioscler Thromb Vasc Biol 25 (2005) 1280-1286
22. Clauser S., Peyrard S., Gaussem P., et al. Development of a novel immunoassay for the assessment of plasma gas6 concentrations and their variation with hormonal status. Clin Chem 53 (2007) 1808-1813
23. Levine B., Kalman J., Mayer L., Fillit H.M., and Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 323 (1990) 236-241
24. Aukrust P., Ueland T., Muller F., et al. Elevated circulating levels of C-C chemokines in patients with congestive heart failure. Circulation 97 (1998) 1136-1143
25. Yndestad A., Damas J.K., Oie E., Ueland T., Gullestad L., and Aukrust P. Systemic inflammation in heart failure-the whys and wherefores. Heart Fail Rev 11 (2006) 83-92
26. Saller F., Burnier L., Schapira M., and Angelillo-Scherrer A. Role of the growth arrest-specific gene 6 (gas6) product in thrombus stabilization. Blood Cells Mol Dis 36 (2006) 373-378
27. Cranenburg E.C.M., Schurgers L.J., and Vermeer C. Vitamin K: The coagulation vitamin that become omnipotent. Thromb Haemost 98 (2007) 120-125
28. Gheorghiade M., Zannad F., Sopko G., et al. International Working Group on Acute Heart Failure Syndromes. Acute heart failure syndromes: current state and framework for future research. Circulation 112 (2005) 3958-3968
29. Levy M.M., Fink M.P., Marshall J.C., et al. International Sepsis Definitions Conference. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29 (2003) 530-538