Physiological plasma Gas6 levels do not influence platelet aggregation [2]

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 3, 2006, Pages

  Clauser, Sylvain ^a   Bachelot lozat, Christilla ^a   Fontana, Pierre ^b   Gaussem, Pascale ^a   Remones, Véronique ^a   Aiach, Martine ^a   Borgel, Delphine ^a  

^a INSERM   (France)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; GROWTH ARREST SPECIFIC PROTEIN 6;

APOPTOSIS; HUMAN; KNOCKOUT MOUSE; LETTER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; THROMBOCYTE AGGREGATION;

ADOLESCENT; ADULT; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PLATELET AGGREGATION;

EID: 33646563486     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000201968.72967.f9     Document Type: Letter

References (8)

1. Manfioletti G, Brancolini C, Avanzi G, Schneider C. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol. 1993;13:4976-4985.
2. Angelillo-Scherrer A, de Frutos P, Aparicio C, Melis E, Savi P, Lupu F, Arnout J, Dewerchin M, Hoylaerts M, Herbert J, Collen D, Dahlback B, Carmeliet P. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001;7:215-221.
3. Angelillo-Scherrer A, Brunier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert J, Lemke G, Goff SP, Matsushima GK, Earp HS, Vesin C, Hoylaerts M, Plaisance S, Collen D, Conway EM, Arnout J, Wehrle-Haller B, Carmeliet P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest. 2005;115:237-246.
4. Ishimoto Y, Nakano T. Release of a product of growth arrest-specific gene 6 from rat platelets. FEBS Lett. 2000;466:197-199.
5. Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA. Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. J Thromb Haemost. 2005;3:733-741.
6. Balogh I, Hafizi S, Stenhoff J, Hansson K, Dahlbach B. Analysis of Gas6 in human platelets and plasma. Arterioscler Thromb Vasc Biol. 2005;25:1280-1286.
7. Borgel D, Clauser S, Bornstain C, Bièche I, Bissery A, Remones V, Fagon JY, Martine Aiach M, Diehl JL. Elevated Gas6 plasma levels in patients with severe sepsis. Crit Care Med. 2006;34:219-222.
8. Dupont A, Fontana P, Bachelot-Loza C, Reny JL, Bieche I, Desvard F, Aiach M, Gaussem P. An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN. Blood. 2003;101:1833-1840.