메뉴 건너뛰기




Volumn 23, Issue 1-3, 2002, Pages 11-17

Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons

Author keywords

Brain derived neurotrophic factor; N methyl D aspartate; Neuroprotection; Phosphatidylinositol 3 kinase Akt; Rat cerebellar granule cells; TrkB receptor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DIZOCILPINE; K 252A; N METHYL DEXTRO ASPARTIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR;

EID: 0036389374     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-001-0103-9     Document Type: Conference Paper
Times cited : (30)

References (39)
  • 1
    • 0033560120 scopus 로고    scopus 로고
    • Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival
    • Blair LA, Bence-Hanulec KK, Mehta S, Franke T, Kaplan D, Marshall J (1999) Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival. J Neurosci 19: 1940-1951
    • (1999) J Neurosci , vol.19 , pp. 1940-1951
    • Blair, L.A.1    Bence-Hanulec, K.K.2    Mehta, S.3    Franke, T.4    Kaplan, D.5    Marshall, J.6
  • 2
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and disease of the nervous system
    • Choi DW (1988) Glutamate neurotoxicity and disease of the nervous system. Neuron 1: 623-634
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 3
    • 0028799654 scopus 로고
    • Calcium: Still center-stage in hypoxic-ischemic neuronal death
    • Choi DW (1995) Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 18: 58-60
    • (1995) Trends Neurosci , vol.18 , pp. 58-60
    • Choi, D.W.1
  • 4
    • 0029807471 scopus 로고    scopus 로고
    • Akt is a direct target of the phosphatidylinositol 3-kinase
    • Datta K, Bellacosa A, Chan TO, Tsichlis PN (1996) Akt is a direct target of the phosphatidylinositol 3-kinase. J Biol Chem 271: 30835-30839
    • (1996) J Biol Chem , vol.271 , pp. 30835-30839
    • Datta, K.1    Bellacosa, A.2    Chan, T.O.3    Tsichlis, P.N.4
  • 6
    • 0035282951 scopus 로고    scopus 로고
    • C-src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway
    • Encinas M, Tansey MG, Tsui-Pierchala BA, Comella JX, Milbrandt J, Johnson EM Jr (2001) C-src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway. J Neurosci 21: 1464-1472
    • (2001) J Neurosci , vol.21 , pp. 1464-1472
    • Encinas, M.1    Tansey, M.G.2    Tsui-Pierchala, B.A.3    Comella, J.X.4    Milbrandt, J.5    Johnson E.M., Jr.6
  • 7
    • 0001280792 scopus 로고
    • Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex
    • Favaron M, Manev H, Alho H (1988) Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc Natl Acad Sci USA 85: 7351-7355
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7351-7355
    • Favaron, M.1    Manev, H.2    Alho, H.3
  • 8
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-biphosphate
    • Franke TF, Kaplan DR, Cantley LC, Toker A (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-biphosphate. Science 275: 665-668
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 9
    • 0028987937 scopus 로고
    • Calcium signaling in neurons: Molecular mechanisms and cellular consequences
    • Ghosh A, Greenberg ME (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268: 239-247
    • (1995) Science , vol.268 , pp. 239-247
    • Ghosh, A.1    Greenberg, M.E.2
  • 10
    • 0035839556 scopus 로고    scopus 로고
    • Akt down regulation of p38 signaling provides a novel mechanism of VEGF mediated cytoprotection in endothelial cells
    • in press
    • Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, Sessa WC (2001) Akt down regulation of p38 signaling provides a novel mechanism of VEGF mediated cytoprotection in endothelial cells. J Biol Chem (in press)
    • (2001) J Biol Chem
    • Gratton, J.P.1    Morales-Ruiz, M.2    Kureishi, Y.3    Fulton, D.4    Walsh, K.5    Sessa, W.C.6
  • 11
    • 0025317838 scopus 로고
    • Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
    • Hohn A, Leibrock J, Bailey K, Barde Y-A (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344: 339-341
    • (1990) Nature , vol.344 , pp. 339-341
    • Hohn, A.1    Leibrock, J.2    Bailey, K.3    Barde, Y.-A.4
  • 12
    • 0033740346 scopus 로고    scopus 로고
    • Neuronal death enhanced by N-methyl-D-aspartate antagonists
    • Ikonomidou C, Stefovska V, Turski L (2000) Neuronal death enhanced by N-methyl-D-aspartate antagonists. Proc Natl Acad Sci USA 97: 12885-12890
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12885-12890
    • Ikonomidou, C.1    Stefovska, V.2    Turski, L.3
  • 13
    • 0025017949 scopus 로고
    • Molecular cloning of a human gene that is a member of the nerve growth factor family
    • Jones KR, Reichardt LF (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci USA 87: 8060-8064
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8060-8064
    • Jones, K.R.1    Reichardt, L.F.2
  • 14
    • 0029963657 scopus 로고    scopus 로고
    • Synaptic activity and the construction of cortical circuits
    • Katz LC, Shatz CJ (1996) Synaptic activity and the construction of cortical circuits. Science 274: 1133
    • (1996) Science , vol.274 , pp. 1133
    • Katz, L.C.1    Shatz, C.J.2
  • 15
    • 0034648666 scopus 로고    scopus 로고
    • Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway
    • Kim I, Kim JH, Moon SO, Kwak HJ, Kim NG, Koh GY (2000) Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway. Oncogene 19: 4549-4552
    • (2000) Oncogene , vol.19 , pp. 4549-4552
    • Kim, I.1    Kim, J.H.2    Moon, S.O.3    Kwak, H.J.4    Kim, N.G.5    Koh, G.Y.6
  • 16
    • 0025857391 scopus 로고
    • The trk proto-oncogene encodes a receptor for nerve growth factor
    • Klein R, Jing S, Nanduri V, O'Rourke E, Barbacid M (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65: 189-197
    • (1991) Cell , vol.65 , pp. 189-197
    • Klein, R.1    Jing, S.2    Nanduri, V.3    O'Rourke, E.4    Barbacid, M.5
  • 17
    • 0023877523 scopus 로고
    • Vulnerability of cultured cortical neurons to damage by excitotoxins: Differential susceptibility of neurons containing NADPH-diaphorase
    • Koh J, Choi DW (1988a) Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase. J Neurosci 8: 2153-2163
    • (1988) J Neurosci , vol.8 , pp. 2153-2163
    • Koh, J.1    Choi, D.W.2
  • 18
    • 0023905988 scopus 로고
    • Zinc alters excitatory amino acid neurotoxicity on cortical neurons
    • Koh J, Choi DW (1988b) Zinc alters excitatory amino acid neurotoxicity on cortical neurons. J Neurosci 8: 2164-2171.
    • (1988) J Neurosci , vol.8 , pp. 2164-2171
    • Koh, J.1    Choi, D.W.2
  • 19
    • 0025944524 scopus 로고
    • TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
    • Lamballe F, Klein R, Barbacid M (1991) TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66: 967-979
    • (1991) Cell , vol.66 , pp. 967-979
    • Lamballe, F.1    Klein, R.2    Barbacid, M.3
  • 20
    • 0023236055 scopus 로고
    • The nerve growth factor 35 years later
    • Levi-Montalcini R (1987) The nerve growth factor 35 years later. Science 237: 1154-1162
    • (1987) Science , vol.237 , pp. 1154-1162
    • Levi-Montalcini, R.1
  • 21
    • 0027423233 scopus 로고
    • Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity
    • Lindholm D, Dechant G, Heisenberg CP, Thoenen H (1993) Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. Eur J Neurosci 5: 1455-1464
    • (1993) Eur J Neurosci , vol.5 , pp. 1455-1464
    • Lindholm, D.1    Dechant, G.2    Heisenberg, C.P.3    Thoenen, H.4
  • 22
    • 0034742675 scopus 로고    scopus 로고
    • Nuclear factor kappa B is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection
    • Lipsky RH, Xu K, Zhu D, Kelly C, Terhakopian A, Novelli A, Marini AM (2001) Nuclear factor kappa B is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection. J Neurochem 78: 254-264
    • (2001) J Neurochem , vol.78 , pp. 254-264
    • Lipsky, R.H.1    Xu, K.2    Zhu, D.3    Kelly, C.4    Terhakopian, A.5    Novelli, A.6    Marini, A.M.7
  • 24
    • 0026079248 scopus 로고
    • The glutamate uptake blocker DL-threo-3-hydroxyaspartate reduces NMDA receptor activation by glutamate in cultured neurons
    • Marini AM, Novelli A (1991) The glutamate uptake blocker DL-threo-3-hydroxyaspartate reduces NMDA receptor activation by glutamate in cultured neurons. Europ J Pharm 194: 131-132
    • (1991) Europ J Pharm , vol.194 , pp. 131-132
    • Marini, A.M.1    Novelli, A.2
  • 25
    • 0026747874 scopus 로고
    • N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis
    • Marini AM, Paul SM (1992) N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis. Proc Natl Acad Sci USA 89: 6555-6559
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6555-6559
    • Marini, A.M.1    Paul, S.M.2
  • 26
    • 0032491387 scopus 로고    scopus 로고
    • Activity-dependent release of brain-derived neurotropic factor underlies the neuroprotective effect of N-methyl-D-aspartate
    • Marini AM, Rabin SJ, Lipsky RH, Mocchetti I (1998) Activity-dependent release of brain-derived neurotropic factor underlies the neuroprotective effect of N-methyl-D-aspartate. J Biol Chem 273: 29394-29399
    • (1998) J Biol Chem , vol.273 , pp. 29394-29399
    • Marini, A.M.1    Rabin, S.J.2    Lipsky, R.H.3    Mocchetti, I.4
  • 27
    • 0030938816 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I- mediated survival of cerebellar granule cells
    • Miller TM, Tansey MG, Johnson EM Jr, Creedon DJ (1997) Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I- mediated survival of cerebellar granule cells. J Biol Chem 272: 9847-9853
    • (1997) J Biol Chem , vol.272 , pp. 9847-9853
    • Miller, T.M.1    Tansey, M.G.2    Johnson E.M., Jr.3    Creedon, D.J.4
  • 28
    • 0034307305 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cells
    • Ng SSW, Tsao MS, Chow S, Hedley DW (2000) Inhibition of phosphatidylinositol 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cells. Cancer Res 60: 5451-5455
    • (2000) Cancer Res , vol.60 , pp. 5451-5455
    • Ng, S.S.W.1    Tsao, M.S.2    Chow, S.3    Hedley, D.W.4
  • 29
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
    • Novelli A, Reilly JA, Lysko PG, Henneberry RC (1988) Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res 451: 205-212
    • (1988) Brain Res , vol.451 , pp. 205-212
    • Novelli, A.1    Reilly, J.A.2    Lysko, P.G.3    Henneberry, R.C.4
  • 30
    • 0015175326 scopus 로고
    • Cytotoxic effects of acidic and sulphur-containing amino acids on the infant mouse central nervous system
    • Olney JW, Ho OL, Rhee V (1971) Cytotoxic effects of acidic and sulphur-containing amino acids on the infant mouse central nervous system. Exp Brain Res 14: 61-76
    • (1971) Exp Brain Res , vol.14 , pp. 61-76
    • Olney, J.W.1    Ho, O.L.2    Rhee, V.3
  • 31
    • 0025321521 scopus 로고
    • Binding of brain-derived neurotrophic factor to the nerve growth factor receptor
    • Rodriguez-Tebar A, Dechant G, Barde YA (1990) Binding of brain-derived neurotrophic factor to the nerve growth factor receptor. Neuron 4: 487-492
    • (1990) Neuron , vol.4 , pp. 487-492
    • Rodriguez-Tebar, A.1    Dechant, G.2    Barde, Y.A.3
  • 33
    • 0025139268 scopus 로고
    • Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: Role of the glutamate receptor responsive to N-methyl-D-aspartate
    • Schramm M, Eimerl S, Costa E (1990) Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate. Proc Natl Acad Sci USA 87: 1193-1197
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1193-1197
    • Schramm, M.1    Eimerl, S.2    Costa, E.3
  • 34
    • 0029040938 scopus 로고
    • Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells
    • Segal RA, Pomeroy SL, Stiles CD (1995) Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci 15: 4970-4981
    • (1995) J Neurosci , vol.15 , pp. 4970-4981
    • Segal, R.A.1    Pomeroy, S.L.2    Stiles, C.D.3
  • 35
    • 0022344980 scopus 로고
    • Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist
    • Wieloch T (1985) Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. Science 230: 681-683
    • (1985) Science , vol.230 , pp. 681-683
    • Wieloch, T.1
  • 36
    • 0033120296 scopus 로고    scopus 로고
    • Evidence for and against a pivotal role of PI-3 kinase in a neuronal cell survival pathway
    • Williams EJ, Doherty P (1999) Evidence for and against a pivotal role of PI-3 kinase in a neuronal cell survival pathway. Mol Cell Neurosci 13: 272-280
    • (1999) Mol Cell Neurosci , vol.13 , pp. 272-280
    • Williams, E.J.1    Doherty, P.2
  • 37
    • 0035957951 scopus 로고    scopus 로고
    • INFα/β promotes cell survival by activating NF-κB through phosphatidylinositol-3 kinase and Akt
    • Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB, Pfeffer LM (2001) INFα/β promotes cell survival by activating NF-κB through phosphatidylinositol-3 kinase and Akt. J Biol Chem 276: 13756-13761
    • (2001) J Biol Chem , vol.276 , pp. 13756-13761
    • Yang, C.H.1    Murti, A.2    Pfeffer, S.R.3    Kim, J.G.4    Donner, D.B.5    Pfeffer, L.M.6
  • 38
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol 3-kinase in the prevention of apoptosis by nerve growth factor
    • Yao R, Cooper GM (1995) Requirement for phosphatidylinositol 3-kinase in the prevention of apoptosis by nerve growth factor. Science 267: 2003-2006
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2
  • 39
    • 0034651876 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinotositol-3 kinase/Akt pathway
    • Zhang L, Himi T, Morita I, Murota S (2000) Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinotositol-3 kinase/Akt pathway. J Neurosci Res 59: 489-496
    • (2000) J Neurosci Res , vol.59 , pp. 489-496
    • Zhang, L.1    Himi, T.2    Morita, I.3    Murota, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.