Purified herpes simplex type 1 glycoprotein D (gD) genetically fused with the type 16 human papillomavirus E7 oncoprotein enhances antigen-specific CD8 + T cell responses and confers protective antitumor immunity

Molecular Pharmaceutics

Volumn 8, Issue 6, 2011, Pages 2320-2330

  Porchia, Bruna F M M ^a   Diniz, Mariana O ^a   Cariri, Francisco A M O ^a   Santana, Vinícius C ^a   Amorim, Jaime H ^a   Balan, Andrea ^b   Braga, Catarina J M ^a   Ferreira, Luís Carlos S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

Author keywords

anticancer vaccines; E7 oncoprotein; gD; HPV 16; HSV 1; papillomavirus vaccines

Indexed keywords

ADJUVANT; CD40 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CELL RECEPTOR; DNA VACCINE; GAMMA INTERFERON; GLYCOPROTEIN D ONCOPROTEIN E7 FUSION PROTEIN; HYBRID PROTEIN; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG MECHANISM; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOMODULATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN EXPRESSION; TUMOR IMMUNITY;

ANIMALS; ANTIGENS, CD8; ANTINEOPLASTIC AGENTS; HERPESVIRUS 1, HUMAN; HUMAN PAPILLOMAVIRUS 16; MICE; MICE, INBRED C57BL; PAPILLOMAVIRUS E7 PROTEINS; RECOMBINANT PROTEINS; T-LYMPHOCYTES; VACCINES, DNA; VIRAL ENVELOPE PROTEINS;

EID: 82955240694     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200194s     Document Type: Article

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