Identification of interactions involved in the generation of nucleophilic reactivity and of catalytic competence in the catalytic site Cys/His ion pair of papain

Biochemistry

Volumn 50, Issue 49, 2011, Pages 10732-10742

  Hussain, Syeed ^a   Khan, Akavish ^a   Gul, Sheraz ^a,d   Resmini, Marina ^a   Verma, Chandra S ^b   Thomas, Emrys W ^c   Brocklehurst, Keith ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b BIOINFORMATICS INSTITUTE   (Singapore)

^c UNIVERSITY OF SALFORD   (United Kingdom)

^d European ScreeningPort GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE CENTER; CATALYTIC MECHANISMS; CATALYTIC SITES; COMPUTER MODELING; CYSTEINE PROTEINASE; DYNAMIC PHENOMENA; ENZYME MOLECULES; HYDROGEN BONDINGS; ION PAIRS; N-PROPYL; NON-COVALENT INTERACTION; NUCLEOPHILIC REACTIVITY; OXYANION HOLE; OXYANIONS; PAPAIN FAMILY; PH-DEPENDENT;

AMIDES; AMINO ACIDS; HYDROGEN BONDS; POSITIVE IONS;

ENZYMES;

3,3' DIPYRIDAZINYL DISULFIDE; 4,4' DIPYRIMIDYL DISULFIDE; AMIDE; BENZENE DERIVATIVE; CYSTEINE; DISULFIDE; GLUTAMINE; HISTIDINE; N PROPYL 3 PYRIDAZINYL DISULFIDE; PAPAIN; PHENYL 3 PYRIDAZINYL DISULFIDE; PROPANE; PYRIDAZINE 3 THIONE; PYRIDAZINE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPUTER MODEL; ENZYME ACTIVE SITE; HYDROGEN BOND; IONIZATION; PH; PKA; PRIORITY JOURNAL;

CATALYTIC DOMAIN; DISULFIDES; HISTIDINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; PAPAIN; PYRIMIDINES; TRYPTOPHAN;

EID: 82955240586     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201207z     Document Type: Article

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