Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E2 receptor EP2 through cAMP elevation and protein kinase A

FEBS Journal

Volumn 275, Issue 14, 2008, Pages 3669-3679

  Sokolova, Elena ^a   Hartig, Roland ^a   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

cAMP; E prostanoid receptor; Lung fibroblasts; Prostaglandin E2; Protease activated receptor 1

Indexed keywords

ADENOSINE RECEPTOR; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROTEINASE ACTIVATED RECEPTOR 1; ALA 4 FLUORO PHE ARG CYCLOHEXYL ALA HOMOARG TYR NH2; ALA-4-FLUORO-PHE-ARG-CYCLOHEXYL-ALA-HOMOARG-TYR-NH2; FORSKOLIN; OLIGOPEPTIDE; PROSTAGLANDIN EP2 RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; FIBROBLAST; GENETICS; LUNG; METABOLISM; PROTEIN SYNTHESIS; RNA STABILITY;

CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; DOWN-REGULATION; FIBROBLASTS; FORSKOLIN; HUMANS; LUNG; OLIGOPEPTIDES; PROTEIN BIOSYNTHESIS; RECEPTOR, PAR-1; RECEPTORS, PROSTAGLANDIN E; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 50549086078     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06511.x     Document Type: Article

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