Effects of hypertonic saline on CD4 +CD25 +Foxp3 + regulatory T cells after hemorrhagic shock in relation to iNOS and cytokines

Journal of Surgical Research

Volumn 172, Issue 1, 2012, Pages 137-145

  Isayama, Kenji ^a   Murao, Yoshinori ^b   Saito, Fukuki ^a   Hirakawa, Akihiko ^a   Nakatani, Toshio ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

cytokine; Foxp3 + Tregs; hemorrhagic shock; hypertonic saline; immunosuppression; iNOS

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RINGER LACTATE SOLUTION; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FLUID RESUSCITATION; GENE INACTIVATION; HEMORRHAGIC SHOCK; IMMUNOFLUORESCENCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHED BLOOD; SPLEEN; THYMUS;

ANIMALS; ANTIGENS, CD4; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; IMMUNE SYSTEM; IMMUNOSUPPRESSION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; NITRIC OXIDE SYNTHASE TYPE II; RESUSCITATION; SALINE SOLUTION, HYPERTONIC; SHOCK, HEMORRHAGIC; T-LYMPHOCYTES, REGULATORY; TIME FACTORS;

EID: 82955213482     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.07.042     Document Type: Article

References (29)

1. A.B. Peitzman, T.R. Billiar, and B.G. Harbrecht Hemorrhagic shock Curr Probl Surg 32 1995 925
2. R.M. Roumen, T. Hendriks, and J. van der Ven-Jongekrijg Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure Ann Surg 218 1993 769
3. V. Kahlke, C. Dohm, and T. Mees Early interleukin-10 treatment improves survival and enhances immune function only in males after hemorrhage and subsequent sepsis Shock 18 2002 24
4. + Regulatory T cells and γδT cells after hemorrhagic shock and resuscitation in relation to Apoptosis and iNOS J Trauma 67 2009 975
5. Y. Belkaid, and B.T. Rouse Natural regulatory T cells in infectious disease Nat Immunol Review 6 2005 353
6. K.S. Goudy, B.R. Burkhardt, and C. Wasserfall Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion J Immunol 171 2003 2270
7. Y. Murao, D.B. Hoyt, and W. Loomis Does the timing of hypertonic saline resuscitation affect its potential to prevent lung damage? Shock 14 2000 18
8. Y. Murao, M. Hata, and K. Ohnishi Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock Shock 20 2003 23
9. M. Bhatia, R.D. Ramnath, and L. Chevali Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis Am J Physiol Gastrointest Liver Physiol Epub 288 2005 1259
10. T. Koshiba, Y. Li, and M. Takemura Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation Transpl Immunol 17 2007 94
11. Y.C. Hsieh, M. Frink, and T. Kawasaki Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage J Cell Physiol 211 2007 364
12. W.H. Loomis, S. Namiki, and D.B. Hoyt Hypertonicity rescues T cells from suppression by trauma-induced anti-inflammatory mediators Am J Physiol Cell Physiol 281 2001 840
13. R. Coimbra, W.G. Junger, and D.B. Hoyt Hypertonic saline resuscitation restores hemorrhage-induced immunosuppression by decreasing prostaglandin E2 and interleukin-4 production J Surg Res 64 1996 203
14. C. Hierholzer, B. Harbrecht, and J.M. Menezes Essential role of induced nitric oxide in the initiation of the inflammatory response following hemorrhagic shock J Exp Med 187 1998 917
15. C. Hierholzer, and T.R. Billiar Molecular mechanisms in the early phase of hemorrhagic shock Langenbecks Arch Surg 386 2001 302
16. C. Thiemermann Beneficial effects of erythropoietin in preclinical models of shock and organ failure Crit Care 11 2007 132
17. M.E. de Vera, R.A. Shapiro, and A.K. Nussler Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: Initial analysis of the human NOS2 promoter Proc Natl Acad Sci USA 93 1996 1054
18. A. Schwentker, Y. Vodovotz, and R. Weller Nitric oxide and wound repair: Role of cytokines? Nitric Oxide 7 2002 1
19. T.A. Meyer, G.M. Tiao, and J.H. James Nitric oxide inhibits LPS-induced IL-6 production in enterocytes J Surg Res 58 1995 570
20. W. Niedbala, B. Cai, and F.Y. Liew Role of nitric oxide in the regulation of T cell functions Ann Rheum Dis 65 2006 37
21. T. Barkhausen, F. Hildebrand, and C. Krettek DHEA-dependent and organ-specific regulation of TNF-alpha mRNA expression in a murine polymicrobial sepsis and trauma model Crit Care 13 2009 R114
22. L.F. Huang, Y.M. Yao, and L.T. Zhang The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats Shock 31 2009 322
23. N. Wisnoski, C.S. Chung, and Y. Chen The contribution of CD4+CD25+ T-regulatory-cells to immune suppression in sepsis Shock 27 2007 251
24. J. Deree, T. de Campos, and E. Shenvi Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: The kinder, gentler resuscitation J Trauma 62 2007 818
25. C.R. Phillips, K. Vinecore, and D.S. Hagg Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: Effects on oxygenation, extravascular lung water and haemodynamics Crit Care 13 2009 R30
26. T.L. Nydam, E.E. Moore, and R.C. McIntyre Jr. Hypertonic saline attenuates TNF-α-induced NF-κB activation in pulmonary epithelial cells Shock 31 2009 466
27. R.S. Hotchkiss, K.W. Tinsley, and P.E. Swanson Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans J Immunol 166 2001 6952
28. P.O. Scumpia, M.J. Delano, and K.M. Kelly Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis J Immunol 177 2006 7943
29. F. Venet, A. Pachot, and A.L. Debard Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes Crit Care Med 32 2004 2329