Ganoderma lucidum polysaccharides reduce methotrexate-induced small intestinal damage in mice via induction of epithelial cell proliferation and migration

Acta Pharmacologica Sinica

Volumn 32, Issue 12, 2011, Pages 1505-1512

  Chen, Li Hua ^a,b   Lin, Zhi Bin ^a   Li, Wei Dong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CHANGSHA MEDICAL UNIVERSITY   (China)

Author keywords

chemotherapy; Ganoderma lucidum polysaccharides; IEC 6 cell line; methotrexate; small intestine injury

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; GANODERMA LUCIDUM EXTRACT; GANODERMA LUCIDUM POLYSACCHARIDE; IMMUNOGLOBULIN A; MALONALDEHYDE; MESSENGER RNA; METHOTREXATE; MYC PROTEIN; ORNITHINE DECARBOXYLASE; POLYSACCHARIDE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CELL LINE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GANODERMA LUCIDUM; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; IMMUNOASSAY; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; INJECTION; INJURY SEVERITY; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; LOW DRUG DOSE; MORPHOLOGICAL TRAIT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE;

ANIMALS; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; INTESTINE, SMALL; METHOTREXATE; MICE; MICE, INBRED BALB C; POLYSACCHARIDES; REISHI;

EID: 82955194985     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.126     Document Type: Article

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