N-3 and n-6 fatty acids stimulate restitution by independent mechanisms in the IEC-6 model of intestinal wound healing

Journal of Nutritional Biochemistry

Volumn 13, Issue 1, 2002, Pages 27-35

  Ruthig, Derek J ^a   Meckling Gill, Kelly A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Cell culture; Intestine; N 3; N 6; Polyunsaturated fatty acid; Restitution

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; DOCOSAPENTAENOIC ACID; ICOSANOID; LIPOXYGENASE INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NORDIHYDROGUAIARETIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHOLIPASE A2; PHOSPHOLIPID; PIROXICAM; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENZYME INHIBITION; INTESTINE CELL; INTESTINE INJURY; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN SYNTHESIS; RAT; WOUND HEALING;

EID: 0036154316     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-2863(01)00192-9     Document Type: Article

References (44)

1. Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine
2. The roles of ethanol and of acid in the production of gastric mucosal erosions in rats
3. Mechanism for rapid-epithelialization of the gastric mucosal surface
4. Regeneration of gastric mucosa after aspirin induced injury to the rat
5. Both n-3 and n-6 fatty acids stimulate wound healing in the rat intestinal epithelial cell line, IEC-6
6. Transforming growth factor β regulation of migration in wounded rat intestinal epithelial monolayers
7. Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β
8. Fibroblast growth factors modulate intestinal epithelial cell growth and migration
9. Role of prostaglandins in intestinal epithelial restitution stimulated by growth factors
10. Migration of IEC-6 cells: A model for mucosal healing
11. 2 stimulation of rat intestinal epithelial cell (IEC-6) migration
12. Biochemical adaptation of cardiac and skeletal muscle to physical activity
13. Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro
14. Increased TGF-beta and decreased oncogene expression by omega-3 fatty acids in the spleen delays onset of autoimmune disease in B/W mice
15. Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor β is dependent on the presence of polyunsaturated fatty acids
16. Membrane lipid composition and cellular function
17. Long term effects of dietary marine n-3 fatty acids upon plasma and cellular lipids, platelet function and eicosanoid formation in humans
18. The modification of the arachidonic acid cascade by n-3 fatty acids
19. Eicosanoids and the gastrointestinal tract
20. Regulation of nucleoside drug toxicity by transport inhibitors and omega-3 polyunsaturated fatty acids in normal and transformed rat-2 fibroblasts
21. EPA and DHA alter nucleoside drug and adriamycin toxicity in L1210 leukemia cells but not in normal bone marrow derived S1 macrophages
22. NSAIDs, gastrointestinal injury, and cytoprotection
23. Cyclooxygenase-2 inhibitors
24. 2 inhibitor which prevents prostaglandin generation
25. 2 inhibitory protein in rabbit neutrophils induced by glucocorticoids
26. Corticosteroids suppress cyclooxygenase messenger RNA levels and prostanoid synthesis in cultured vascular cells
27. A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein
28. Induction and suppression of prostaglandin H2 synthase(cyclooxygenase) in human monocytes
29. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice
30. Cyclooxygenase in biology and disease
31. Inflammatory mediators in gastrointestinal defence and injury
32. Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages
33. Relative activities of retrovirally expressed murine prostaglandin synthase-1 and -2 depend on source of arachidonic acid
34. Differential allosteric regulation of Prostaglandin H Synthase 1 and 2 by arachidonic acid
35. 2 reduces chenodeoxycholate-induced small intestinal mucosal injury in the rat
36. 2 and indomethacin on bile acid-induced intestinal injury and restitution in rats
37. 2 induces villus contraction in rats without affecting intestinal restitution
38. Enhancement of migration in bovine endothelial cells by eicosapentaenoic acid pretreatment
39. Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro
40. Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats
41. DHA feeding provides host protection and prevents fibrosarcoma-induced hyperlipidemia while maintaining the tumor response to araC in Fischer 344 rats
42. Min/+ mice
43. Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues
44. Consumption of fish oil leads to prompt incorporation of eicosapentaenoic acid into colonic mucosa of patients prior to surgery for colorectal cancer, but has no detectable effect on epithelial cytokinetics