Heritability of tpeak-tend interval and T-Wave amplitude a twin study

Circulation: Cardiovascular Genetics

Volumn 4, Issue 5, 2011, Pages 516-522

  Haarmark, Christian ^a,b,c   Kyvik, Kirsten O ^d,e   Vedel Larsen, Esben ^a,b   Budtz Jørgensen, Esben ^b   Kanters, Jørgen K ^a,b  

^a Laboratory of Experimental Cardiology   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Department of Clinical Physiology and Nuclear Medicine ^*  (Denmark)

^d FREDERIKSBERG HOSPITAL   (Denmark)

^e ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cardiac electrophysiology; Electrocardiography; Heredity; Twins

Indexed keywords

ADULT; ARTICLE; BODY MASS; CORRELATION ANALYSIS; DIZYGOTIC TWINS; ELECTROCARDIOGRAPHY; FEMALE; GENETIC ANALYSIS; HEART RATE; HERITABILITY; HUMAN; MALE; MONOZYGOTIC TWINS; PRIORITY JOURNAL; QT INTERVAL; T WAVE AMPLITUDE; TPEAK TEND INTERVAL;

ADULT; AGE FACTORS; BODY MASS INDEX; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; QUANTITATIVE TRAIT, HERITABLE; SEX FACTORS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; VENTRICULAR FUNCTION;

EID: 82955189766     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.111.959551     Document Type: Article

References (48)

1. Lubinski A, Kornacewicz-Jach Z, Wnuk-Wojnar AM, Adamus J, Kempa M, Krolak T, Lewicka-Nowak E, Radomski M, Swiatecka G. The terminal portion of the T wave: a new electrocardiographic marker of risk of ventricular arrhythmias. Pacing Clin Electrophysiol. 2000;23: 1957-1959.
2. Yamazaki T, Myers J, Froelicher VF. Prognostic importance of isolated T-wave abnormalities. Am J Cardiol. 2005;95:300-304. (Pubitemid 40092110)
3. Jacobsen MD, Wagner GS, Holmvang L, Kontny F, Wallentin L, Husted S, Swahn E, Stahle E, Steffensen R, Clemmensen P. Quantitative T-wave analysis predicts 1 year prognosis and benefit from early invasive treatment in the FRISC II study population. Eur Heart J. 2005;26: 112-118. (Pubitemid 40282778)
4. Haarmark C, Hansen PR, Vedel-Larsen E, Pedersen SH, Graff C, Andersen MP, Toft E, Wang F, Struijk JJ, Kanters JK. The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Electrocardiol. 2009;42:555-560.
5. Hochrein J, Sun F, Pieper KS, Lee KL, Gates KB, Armstrong PW, Weaver WD, Goodman SG, Topol EJ, Califf RM. Higher T-wave amplitude associated with better prognosis in patients receiving thrombolytic therapy for acute myocardial infarction (a GUSTO-I substudy). Am J Cardiol. 1998;81:1078-1084. (Pubitemid 28232675)
6. Kanters JK, Fanoe S, Larsen LA, Bloch Thomsen PE, Toft E, Christiansen M. T wave morphology analysis distinguishes between KvLQT1 and HERG mutations in long QT syndrome. Heart Rhythm. 2004;1: 285-292. (Pubitemid 39549756)
7. Steriotis AK, Bauce B, Daliento L, Rigato I, Mazzotti E, Folino AF, Marra MP, Brugnaro L, Nava A. Electrocardiographic pattern in arrhythmogenic right ventricular cardiomyopathy. Am J Cardiol. 2009;103: 1302-1308.
8. Zhang L, Timothy KW, Vincent GM, Lehmann MH, Fox J, Giuli LC, Shen J, Splawski I, Priori SG, Compton SJ, Yanowitz F, Benhorin J, Moss AJ, Schwartz PJ, Robinson JL, Wang Q, Zareba W, Keating MT, Towbin JA, Napolitano C, Medina A. Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation. 2000;102:2849-2855.
9. Russell MW, Law I, Sholinsky P, Fabsitz RR. Heritability of ECG measurements in adult male twins. J Electrocardiol. 1998;30(supp 1):64-68. (Pubitemid 28145031)
10. Dalageorgou C, Ge D, Jamshidi Y, Nolte I, Riese H, Savelieva I, Carter N, Spector T, Snieder H. Heritability of QT interval: how much is explained by genes for resting heart rate? J Cardiovasc Electrophysiol. 2008;19:386-391. (Pubitemid 351457546)
11. Snieder H, Harshfield GA, Treiber FA. Heritability of blood pressure and hemodynamics in African- and European-American youth. Hypertension. 2003;41:1196-1201. (Pubitemid 36706065)
12. Uusitalo AL, Vanninen E, Levalahti E, Battie MC, Videman T, Kaprio J. Role of genetic and environmental influences on heart rate variability in middle-aged men. Am J Physiol Heart Circ Physiol. 2007;293: H1013-H1022. (Pubitemid 47254200)
13. Hong Y, Rautaharju PM, Hopkins PN, Arnett DK, Djousse L, Pankow JS, Sholinsky P, Rao DC, Province MA. Familial aggregation of QT-interval variability in a general population: results from the NHLBI Family Heart Study. Clin Genet. 2001;59:171-177. (Pubitemid 32229772)
14. Carter N, Snieder H, Jeffery S, Saumarez R, Varma C, Antoniades L, Spector TD. QT interval in twins. J Hum Hypertens. 2000;14:389-390. (Pubitemid 30426695)
15. Hedley PL, Jorgensen P, Schlamowitz S, Wangari R, Moolman-Smook J, Brink PA, Kanters JK, Corfield VA, Christiansen M. The genetic basis of long QT and short QT syndromes: a mutation update. Hum Mutat. 2009;30:1486-1511.
16. Pfeufer A, Sanna S, Arking DE, Muller M, Gateva V, Fuchsberger C, Ehret GB, Orru M, Pattaro C, Kottgen A, Perz S, Usala G, Barbalic M, Li M, Putz B, Scuteri A, Prineas RJ, Sinner MF, Gieger C, Najjar SS, Kao WHL, Muhleisen TW, Dei M, Happle C, Mohlenkamp S, Crisponi L, Erbel R, Jockel K-H, Naitza S, Steinbeck G, Marroni F, Hicks AA, Lakatta E, Muller-Myhsok B, Pramstaller PP, Wichmann HE, Schlessinger D, Boerwinkle E, Meitinger T, Uda M, Coresh J, Kaab S, Abecasis GR, Chakravarti A. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet. 2009;41:407-414.
17. Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science. 2002;297:1333-1336. (Pubitemid 34913168)
18. Benyamin B, Sørensen T, Schousboe K, Fenger M, Visscher P, Kyvik K. Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia. 2007; 50:1880-1888. (Pubitemid 47222870)
19. Hansen PS, van der Deure W, Peeters RP, Iachine I, Fenger M, Sørensen TIA, Kyvik KO, Visser TJ, Hegedüs L. The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population. Clin Endocrinol (Oxf). 2007;66:827-832. (Pubitemid 47024269)
20. Haarmark C, Graff C, Andersen MP, Hardahl T, Struijk JJ, Toft E, Xue J, Rowlandson GI, Hansen PR, Kanters JK. Reference values of electrocardiogram repolarization variables in a healthy population. J Electrocardiol. 2009;43:31-39.
21. Opthof T, Coronel R, Janse MJ. Is there a significant transmural gradient in repolarization time in the intact heart? Repolarization gradients in the intact heart. Circ Arrhythm Electrophysiol. 2009;2:89-96.
22. Patel C, Burke JF, Patel H, Gupta P, Kowey PR, Antzelevitch C, Yan G-X. Cellular basis of the T wave: a century of controversy. Circ Arrhythm Electrophysiol. 2009;2:80-88.
23. Kanters JK, Haarmark C, Vedel-Larsen E, Andersen MP, Graff C, Struijk JJ, Bloch Thomsen PE, Christiansen M, Jensen HK, Toft E. T-peak to T-end (TpTe) interval in long QT syndrome. J Electrocardiol. 2008;41: 603-608.
24. Ozawa T, Ito M, Tamaki S, Yao T, Ashihara T, Kita Y, Okamura T, Ueshima H, Horie M. Gender and age effects on ventricular repolarization abnormality in Japanese general carriers of a G643S common single nucleotide polymorphism for the KCNQ1 gene. Circ J. 2006;70: 645-650. (Pubitemid 43797772)
25. Porthan K, Marjamaa A, Viitasalo M, Vaananen H, Jula A, Toivonen L, Nieminen MS, Newton-Cheh C, Salomaa V, Kontula K, Oikarinen L. Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters. Heart Rhythm. 2010;7:898-903.
26. Pietila E, Fodstad H, Niskasaari E, Laitinen PP, Swan H, Savolainen M, Kesaniemi YA, Kontula K, Huikuri HV. Association between HERG K897T polymorphism and QT interval in middle-aged Finnish women. J Am Coll Cardiol. 2002;40:511-514. (Pubitemid 34833168)
27. Langley P, di Bernado D, Murray A. Quantification of T wave shape changes following exercise. Pacing Clin Electrophysiol. 2002;25: 1230-1234.
28. Yan GX, Lankipalli RS, Burke JF, Musco S, Kowey PR. Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance. J Am Coll Cardiol. 2003;42:401-409. (Pubitemid 36951702)
29. Koskela J, Kahonen M, Fan M, Nieminen T, Lehtinen R, Viik J, Nikus K, Niemela K, Koobi T, Turjanmaa V, Porsti I, Lehtimaki T. Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study. Transl Res. 2008;152: 49-58.
30. Mutikainen S, Ortega-Alonso A, Alén M, Kaprio J, Karjalainen J, Rantanen T, Kujala UM. Genetic influences on resting electrocardiographic variables in older women: a twin study. Ann Noninvasive Electrocardiol. 2009;14:57-64.
31. Havlik RJ, Garrison RJ, Fabsitz R, Feinleib M. Variability of heart rate, P-R, QRS and Q-T durations in twins. J Electrocardiol. 1980;13:45-48. (Pubitemid 10210744)
32. Hanson B, Tuna N, Bouchard T, Heston L, Eckert E, Lykken D, Segal N, Rich S. Genetic factors in the electrocardiogram and heart rate of twins reared apart and together. Am J Cardiol. 1989;63:606-609. (Pubitemid 19070120)
33. De Geus EJ, Boomsma DI, Snieder H. Genetic correlation of exercise with heart rate and respiratory sinus arrhythmia. Med Sci Sports Exerc. 2003;35:1287-1295. (Pubitemid 36936145)
34. Fagard RH, Loos RJ, Beunen G, Derom C, Vlietinck R. Influence of chorionicity on the heritability estimates of blood pressure: a study in twins. J Hypertens. 2003;21:1313-1318.
35. Somes GW, Harshfield GA, Alpert BS, Goble MM, Schicken RM. Genetic influences on ambulatory blood pressure patterns: the Medical College of Virginia twin study. Am J Hypertens. 1995;8:474-478.
36. Snieder H, Hayward CS, Perks U, Kelly RP, Kelly PJ, Spector TD. Heritability of central systolic pressure augmentation : a twin study. Hypertension. 2000;35:574-579. (Pubitemid 30108151)
37. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Evans JC, Levy D. Heritability of heart rate variability: the Framingham Heart Study. Circulation. 1999;99:2251-2254. (Pubitemid 29201130)
38. Busjahn A, Voss A, Knoblauch H, Knoblauch M, Jeschke E, Wessel N, Bohlender J, McCarron J, Faulhaber H-D, Schuster H, Dietz R, Luft FC. Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins. Am J Cardiol. 1998;81: 755-760. (Pubitemid 28146452)
39. Busjahn A, Knoblauch H, Faulhaber HD, Boeckel T, Rosenthal M, Uhlmann R, Hoehe M, Schuster H, Luft FC. QT interval is linked to 2 long-QT syndrome loci in normal subjects. Circulation. 1999;99: 3161-3164. (Pubitemid 29289082)
40. Newton-Cheh C, Larson MG, Corey DC, Benjamin EJ, Herbert AG, Levy D, D'Agostino RB, O'Donnell CJ. QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: the Framingham Heart Study. Heart Rhythm. 2005;2:277-284. (Pubitemid 40309826)
41. Fraley MA, Birchem JA, Senkottaiyan N, Alpert MA. Obesity and the electrocardiogram. Obesity Reviews. 2005;6:275-281. (Pubitemid 41578598)
42. Gollob MH. Genetic profiling as a marker for risk of sudden cardiac death. Curr Opin Cardiol. 2006;21:42-46. (Pubitemid 43194331)
43. Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PIW, Yin X, Estrada K, Bis JC, Marciante K, Rivadeneira F, Noseworthy PA, Sotoodehnia N, Smith NL, Rotter JI, Kors JA, Witteman JCM, Hofman A, Heckbert SR, O'Donnell CJ, Uitterlinden AG, Psaty BM, Lumley T, Larson MG, Stricker BH. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet. 2009;41:399-406.
44. Roden DM. Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med. 2006;259:59-69.
45. Martin N, Boomsma D, Machin G. A twin-pronged attack on complex traits. Nat Genet. 1997;17:387-392. (Pubitemid 27518385)
46. Kyvik KO, Green A, Beck-Nielsen H. Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins. BMJ. 1995;311:913-917.
47. Brix TH, Kyvik KO, Christensen K, Hegedus L. Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab. 2001;86:930-934. (Pubitemid 32207518)
48. Christensen K, Vaupel JW, Holm NV, Yashin AI. Mortality among twins after age 6: fetal origins hypothesis versus twin method. BMJ. 1995;310:432-436.