Familial aggregation of QT-interval variability in a general population: Results from the NHLBI Family Heart Study

Clinical Genetics

Volumn 59, Issue 3, 2001, Pages 171-177

  Hong, Y ^a,h   Rautaharju, Pm ^b   Hopkins, Pn ^c   Arnett, Dk ^d   Djousse L ^e   Pankow, Js ^f   Sholinsky, P ^g   Rao, Dc ^a   Province, Ma ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f IL   (United States)

^g NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^h WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Familial aggregation; Genetic epidemilogy; Heritability; QT interval; Segregation analysis

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CARDIOLOGY; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ASSOCIATION; ELECTROCARDIOGRAPHY; FAMILIAL INCIDENCE; FAMILY STUDY; FEMALE; GENETIC VARIABILITY; HEART DEATH; HEART RATE; HEREDITY; HUMAN; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; MOLECULAR BIOLOGY; MULTIFACTORIAL INHERITANCE; PARENT; POPULATION; PRIORITY JOURNAL; PROGENY; QT INTERVAL; RISK ASSESSMENT; RISK FACTOR; SEGREGATION ANALYSIS; SEX; SIBLING; SPOUSE;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME SEGREGATION; COHORT STUDIES; ELECTROCARDIOGRAPHY; FAMILY HEALTH; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; HEART RATE; HUMANS; LONG QT SYNDROME; MALE; MIDDLE AGED; REGRESSION ANALYSIS; UNITED STATES; VARIATION (GENETICS);

EID: 0035093592     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2001.590305.x     Document Type: Article

References (46)

1. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death
2. An new familial cardiac syndrome in children
3. The long Q-T syndrome
4. Multiple mechanisms in the long-QT syndrome: Current knowledge, gaps, and future directions
5. The molecular genetics of the long QT syndrome: Genes causing fainting and sudden death
6. Molecular basis of the long-QT syndrome associated with disease
7. Influence of the genotype on the clinical course of the long-QT syndrome
8. The molecular basis of long QT syndrome and prospects for therapy
9. Molecular basis of the long-QT syndrome
10. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrthymias
11. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
12. SCN5A mutations associated with an inherited cardiac arrthmia, long QT syndrome
13. Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization
14. Ion channels - Basic science and clinical disease
15. Prognostic value of prolonged ventricular repolarization following myocardial infarction: The BHAT experience
16. QT interval prolongation predict cardiovascular mortality in an apparently healthy population
17. QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest
18. Is QT interval prolongation a strong or weak predictor for cardiac death?
19. Association between QT interval and coronary disease in middle-aged and elderly men
20. Clinically silent electrocardiographic abnormalities and risk of primary cardiac arrest among hypertensive patients
21. Electrocardiography in epidemiology and clinical trials
22. QT interval as a cardiac risk factor in middle aged population
23. Duration of the QT interval and total and cardiovascular mortality in healthy persons - The Framingham Heart Study Experience
24. An analysis of the time-relations of electrocardiograms
25. The normal duration of the QT interval
26. Rate-corrected QT interval: Techniques and limitations
27. Functional characteristics of QT prediction formulas. The concepts of QT max and QT rate sensitivity
28. Estimation of QT prolongation: A persistent, avoidable error in computer electrocardiography
29. Novacode serial ECG classification system for clinical trials and epidemiological studies
30. The NHLBI Family Heart Study: Objectives and design
31. A general purpose model and a computer program for combined segregation and path analysis (SEGPATH): Automatically creating computer programs from symbolic language model specification
32. Familial resemblance for abdominal visceral fat: The HERITAGE Family Study
33. Complex segregation analysis with pointers
34. A unified model for complex segregation analysis
35. Factor analysis and aic
36. Information on type 1 diabetes mellitus and QT interval from identical twins
37. Genetic factors in the electrocardiogram and heart rate of twins reared apart and together
38. Heritability of ECG measurements in adult male twins
39. Genetic and environmental sources of QT interval variability in Israeli families: The kibbutz settlements family study
40. QT interval in twins
41. QT interval is linked to 2 long-QT syndrome loci in normal subjects
42. Acute psychological disturbances preceding life-threating arrhythmias
43. Exercise-induced ventricular arrhythmias and sudden cardiac death in a family
44. Ion channels - Basic science and clinical disease
45. Gender-specific differences in the QT interval and the effect of automic tone and menstrual cycle in healthy adults
46. Evidence for primary genetic determination of heart rate regulation