Lung dendritic cell-epithelial cell crosstalk in Th2 responses to allergens

Current Opinion in Immunology

Volumn 23, Issue 6, 2011, Pages 772-777

  Willart, Monique ^a   Hammad, Hamida ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; B7 ANTIGEN; CD40 ANTIGEN; DECTIN 2; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LECTIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OX40 LIGAND; THYMIC STROMAL LYMPHOPOIETIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ADAPTIVE IMMUNITY; AIRWAY REMODELING; ASTHMA; CELL FUNCTION; CELL MATURATION; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATOPHAGOIDES; EPITHELIUM CELL; HUMAN; LUNG; MOLECULAR INTERACTION; PATTERN RECOGNITION; RESPIRATORY EPITHELIUM; REVIEW; SIGNAL TRANSDUCTION; TH2 CELL;

ALLERGENS; ANIMALS; DENDRITIC CELLS; EPITHELIAL CELLS; HUMANS; LUNG; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 82955188656     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2011.09.008     Document Type: Review

References (73)

1. Lee C.G., Da Silva C.A., Lee J.Y., Hartl D., Elias J.A. Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol 2008, 20:684-689.
2. Wills-Karp M. Allergen-specific pattern recognition receptor pathways. Curr Opin Immunol 2010, 22:777-782.
3. Smit L.A., Bouzigon E., Bousquet J., Le Moual N., Nadif R., Pin I., Lathrop M., Demenais F., Kauffmann F., Siroux V. Mold allergen sensitization in adult asthma according to integrin beta3 polymorphisms and Toll-like receptor 2/+596 genotype. J Allergy Clin Immunol 2011, 128:185-191. e187.
4. Page K., Lierl K.M., Hughes V.S., Zhou P., Ledford J.R., Wills-Karp M. TLR2-mediated activation of neutrophils in response to German cockroach frass. J Immunol 2008, 180:6317-6324.
5. Da Silva C.A., Pochard P., Lee C.G., Elias J.A. Chitin particles are multifaceted immune adjuvants. Am J Respir Crit Care Med 2010, 182:1482-1491.
6. Koller B., Muller-Wiefel A.S., Rupec R., Korting H.C., Ruzicka T. Chitin modulates innate immune responses of keratinocytes. PLoS ONE 2011, 6:e16594.
7. Eisenbarth S.C., Piggott D.A., Huleatt J.W., Visintin I., Herrick C.A., Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002, 196:1645-1651.
8. Piggott D.A., Eisenbarth S.C., Xu L., Constant S.L., Huleatt J.W., Herrick C.A., Bottomly K. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest 2005, 115:459-467.
9. Dabbagh K., Dahl M.E., Stepick-Biek P., Lewis D.B. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 2002, 168:4524-4530.
10. Hammad H., Chieppa M., Perros F., Willart M.A., Germain R.N., Lambrecht B.N. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 2009, 15:410-416.
11. Phipps S., Lam C.E., Kaiko G.E., Foo S.Y., Collison A., Mattes J., Barry J., Davidson S., Oreo K., Smith L., et al. Toll/IL-1 signaling is critical for house dust mite-specific Th1 and Th2 responses. Am J Respir Crit Care Med 2009, 179:883-893.
12. Trompette A., Divanovic S., Visintin A., Blanchard C., Hegde R.S., Madan R., Thorne P.S., Wills-Karp M., Gioannini T.L., Weiss J.P., et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009, 457:585-588.
13. Page K., Ledford J.R., Zhou P., Dienger K., Wills-Karp M. Mucosal sensitization to German cockroach involves protease-activated receptor-2. Respir Res 2010, 11:62.
14. Chapman M.D., Wunschmann S., Pomes A. Proteases as Th2 adjuvants. Curr Allergy Asthma Rep 2007, 7:363-367.
15. Chen J.C., Chuang J.G., Su Y.Y., Chiang B.L., Lin Y.S., Chow L.P. The protease allergen Pen c 13 induce allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model. J Biol Chem 2011, 286:26667-26679.
16. Nathan A.T., Peterson E.A., Chakir J., Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol 2009, 123:612-618.
17. Horner A.A. Regulation of aeroallergen immunity by the innate immune system: laboratory evidence for a new paradigm. J Innate Immun 2010, 2:107-113.
18. Barrett N.A., Maekawa A., Rahman O.M., Austen K.F., Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol 2009, 182:1119-1128.
19. Barrett N.A., Rahman O.M., Fernandez J.M., Parsons M.W., Xing W., Austen K.F., Kanaoka Y. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med 2011, 208:593-604.
20. Page K., Zhou P., Ledford J.R., Day S.B., Lutfi R., Dienger K., Lewkowich I.P. Early immunological response to German cockroach frass exposure induces a Th2/Th17 environment. J Innate Immun 2011, 3:167-179.
21. Lewkowich I.P., Lajoie S., Clark J.R., Herman N.S., Sproles A.A., Wills-Karp M. Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice. PLoS ONE 2008, 3:e3879.
22. Marichal T., Bedoret D., Mesnil C., Pichavant M., Goriely S., Trottein F., Cataldo D., Goldman M., Lekeux P., Bureau F., et al. Interferon response factor 3 is essential for house dust mite-induced airway allergy. J Allergy Clin Immunol 2010, 126:836-844. e813.
23. Kamijo S., Takai T., Kuhara T., Tokura T., Ushio H., Ota M., Harada N., Ogawa H., Okumura K. Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo. J Immunol 2009, 183:6087-6094.
24. Pichavant M., Charbonnier A.S., Taront S., Brichet A., Wallaert B., Pestel J., Tonnel A.B., Gosset P. Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment. J Allergy Clin Immunol 2005, 115:771-778.
25. Osterlund C., Gronlund H., Polovic N., Sundstrom S., Gafvelin G., Bucht A. The non-proteolytic house dust mite allergen Der p 2 induce NF-kappaB and MAPK dependent activation of bronchial epithelial cells. Clin Exp Allergy 2009, 39:1199-1208.
26. Vinhas R., Cortes L., Cardoso I., Mendes V.M., Manadas B., Todo-Bom A., Pires E., Verissimo P. Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides. Allergy 2011, 66:1088-1098.
27. Antony A.B., Tepper R.S., Mohammed K.A. Cockroach extract antigen increases bronchial airway epithelial permeability. J Allergy Clin Immunol 2002, 110:589-595.
28. Wada K., Matsuwaki Y., Moriyama H., Kita H. Cockroach induces inflammatory responses through protease-dependent pathways. Int Arch Allergy Immunol 2011, 155(Suppl. 1):135-141.
29. Wan H., Winton H.L., Soeller C., Taylor G.W., Gruenert D.C., Thompson P.J., Cannell M.B., Stewart G.A., Garrod D.R., Robinson C. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clin Exp Allergy 2001, 31:279-294.
30. Tan A.M., Chen H.C., Pochard P., Eisenbarth S.C., Herrick C.A., Bottomly H.K. TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J Immunol 2010, 184:3535-3544.
31. Poynter M.E., Cloots R., van Woerkom T., Butnor K.J., Vacek P., Taatjes D.J., Irvin C.G., Janssen-Heininger Y.M. NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness. J Immunol 2004, 173:7003-7009.
32. Skerrett S.J., Liggitt H.D., Hajjar A.M., Ernst R.K., Miller S.I., Wilson C.B. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol 2004, 287:L143-L152.
33. Quinton L.J., Jones M.R., Simms B.T., Kogan M.S., Robson B.E., Skerrett S.J., Mizgerd J.P. Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. J Immunol 2007, 178:1896-1903.
34. Ather J.L., Hodgkins S.R., Janssen-Heininger Y.M., Poynter M.E. Airway epithelial NF-kappaB activation promotes allergic sensitization to an innocuous inhaled antigen. Am J Respir Cell Mol Biol 2011, 44:631-638.
35. Sheller J.R., Polosukhin V.V., Mitchell D., Cheng D.S., Peebles R.S., Blackwell T.S. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp Lung Res 2009, 35:883-895.
36. Eiwegger T., Akdis C.A. IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma. Eur J Immunol 2011, 41:1535-1538.
37. Osterlund C., Gronlund H., Gafvelin G., Bucht A. Non-proteolytic aeroallergens from mites, cat and dog exert adjuvant-like activation of bronchial epithelial cells. Int Arch Allergy Immunol 2011, 155:111-118.
38. Stampfli M.R., Wiley R.E., Neigh G.S., Gajewska B.U., Lei X.F., Snider D.P., Xing Z., Jordana M. GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J Clin Invest 1998, 102:1704-1714.
39. Lambrecht B.N., De Veerman M., Coyle A.J., Gutierrez-Ramos J.C., Thielemans K., Pauwels R.A. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 2000, 106:551-559.
40. Zhou L.J., Tedder T.F. CD14(+) blood monocytes can differentiate into functionally mature CD83(+) dendritic cells. Proc Natl Acad Sci USA 1996, 93:2588-2592.
41. Fattouh R., Pouladi M.A., Alvarez D., Johnson J.R., Walker T.D., Goncharova S., Inman M.D., Jordana M. House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation. Am J Respir Crit Care Med 2005, 172:314-321.
42. Yamashita N., Tashimo H., Ishida H., Kaneko F., Nakano J., Kato H., Hirai K., Horiuchi T., Ohta K. Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF). Cell Immunol 2002, 219:92-97.
43. Cates E.C., Fattouh R., Wattie J., Inman M.D., Goncharova S., Coyle A.J., Gutierrez-Ramos J.C., Jordana M. Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. J Immunol 2004, 173:6384-6392.
44. Moon P.D., Kim H.M. Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-kappaB pathway in mast cells. Cytokine 2011, 54:239-243.
45. Kashyap M., Rochman Y., Spolski R., Samsel L., Leonard W.J. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol 2011, 187:1207-1211.
46. Ying S., O'Connor B., Ratoff J., Meng Q., Mallett K., Cousins D., Robinson D., Zhang G., Zhao J., Lee T.H., et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005, 174:8183-8190.
47. Harada M., Hirota T., Jodo A.I., Hitomi Y., Sakashita M., Tsunoda T., Miyagawa T., Doi S., Kameda M., Fujita K., et al. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol 2011, 44:787-793.
48. Bunyavanich S., Melen E., Wilk J.B., Granada M., Soto-Quiros M.E., Avila L., Lasky-Su J., Hunninghake G.M., Wickman M., Pershagen G., et al. Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clin Mol Allergy 2011, 9:1.
49. Zhou B., Comeau M.R., De Smedt T., Liggitt H.D., Dahl M.E., Lewis D.B., Gyarmati D., Aye T., Campbell D.J., Ziegler S.F. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 2005, 6:1047-1053.
50. Wong C.K., Hu S., Cheung P.F., Lam C.W. Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation. Am J Respir Cell Mol Biol 2010, 43:305-315.
51. Lei L., Zhang Y., Yao W., Kaplan M.H., Zhou B. Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol 2011, 186:2254-2261.
52. Zhang F., Huang G., Hu B., Song Y., Shi Y. A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells. Clin Exp Immunol 2011, 164:256-264.
53. Watanabe N., Hanabuchi S., Marloie-Provost M.A., Antonenko S., Liu Y.J., Soumelis V. Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. Blood 2005, 105:4749-4751.
54. Liu Y.J. Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J Allergy Clin Immunol 2007, 120:238-244. quiz 245-236.
55. Wang Y.H., Liu Y.J. Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin Exp Allergy 2009, 39:798-806.
56. Wang Y.H., Angkasekwinai P., Lu N., Voo K.S., Arima K., Hanabuchi S., Hippe A., Corrigan C.J., Dong C., Homey B., et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007, 204:1837-1847.
57. Angkasekwinai P., Park H., Wang Y.H., Chang S.H., Corry D.B., Liu Y.J., Zhu Z., Dong C. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 2007, 204:1509-1517.
58. Kaiko G.E., Phipps S., Angkasekwinai P., Dong C., Foster P.S. NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. J Immunol 2010, 185:4681-4690.
59. Corrigan C.J., Wang W., Meng Q., Fang C., Wu H., Reay V., Lv Z., Fan Y., An Y., Wang Y.H., et al. T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci USA 2011, 108:1579-1584.
60. Corrigan C.J., Wang W., Meng Q., Fang C., Eid G., Caballero M.R., Lv Z., An Y., Wang Y.H., Liu Y.J., et al. Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses. J Allergy Clin Immunol 2011, 128:116-124.
61. Siegle J.S., Hansbro N., Dong C., Angkasekwinai P., Foster P.S., Kumar R.K. Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma. Clin Exp Immunol 2011, 165:19-28.
62. Willart M.A., Lambrecht B.N. The danger within: endogenous danger signals, atopy and asthma. Clin Exp Allergy 2009, 39:12-19.
63. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009, 27:519-550.
64. Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-3732.
65. Lee H.C., Ziegler S.F. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc Natl Acad Sci USA 2007, 104:914-919.
66. Rusznak C., Sapsford R.J., Devalia J.L., Shah S.S., Hewitt E.L., Lamont A.G., Davies R.J., Lozewicz S. Interaction of cigarette smoke and house dust mite allergens on inflammatory mediator release from primary cultures of human bronchial epithelial cells. Clin Exp Allergy 2001, 31:226-238.
67. Oboki K., Nakae S., Matsumoto K., Saito H. IL-33 and airway inflammation. Allergy Asthma Immunol Res 2011, 3:81-88.
68. Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., Zurawski G., Moshrefi M., Qin J., Li X., et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005, 23:479-490.
69. Besnard A.G., Togbe D., Guillou N., Erard F., Quesniaux V., Ryffel B. IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol 2011, 41:1675-1686.
70. Nold M.F., Nold-Petry C.A., Zepp J.A., Palmer B.E., Bufler P., Dinarello C.A. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 2010, 11:1014-1022.
71. Ramadas R.A., Ewart S.L., Medoff B.D., LeVine A.M. Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs. Am J Respir Cell Mol Biol 2011, 44:134-145.
72. Matzinger P. The danger model: a renewed sense of self. Science 2002, 296:301-305.
73. Kool M., Willart M.A., van Nimwegen M., Bergen I., Pouliot P., Virchow J.C., Rogers N., Osorio F., Reis E.S.C., Hammad H., et al. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 2011, 34:527-540.