Not as simple as just punching a hole

Toxicon

Volumn 39, Issue 11, 2001, Pages 1637-1645

  Fivaz, Marc ^a   Abrami, Laurence ^a   Tsitrin, Yulia ^a   Van der Goot, F Gisou ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

A. hydrophila; Aerolysin; GPI anchored protein; Membrane insertion; Oligomerization; Pore forming

Indexed keywords

AEROLYSIN;

AEROMONAS HYDROPHILA; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL INTERACTION; CHANNEL GATING; CYTOLYSIS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; REVIEW; STRESS; STRUCTURE ACTIVITY RELATION; TARGET CELL; TOXIN SYNTHESIS; VIRULENCE;

AEROMONAS; ANIMALS; BACTERIAL TOXINS; CELL DEATH; HUMANS; MODELS, MOLECULAR; PORE FORMING CYTOTOXIC PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

AEROMONAS HYDROPHILA; MAMMALIA;

EID: 0034861304     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00151-9     Document Type: Article

References (77)

1. The pore-forming toxin proaerolysin is processed by furin
2. A pore-forming toxin interact with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum
3. Adventures of a pore-forming toxin at the target cell surface
4. Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin
5. Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by legionella pneumophila
6. Lipids favoring inverted phase enhance the ability of aerolysin To permeabilize liposome bilayers
7. Aeromonas as a human pathogen
8. The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin
9. The channel-forming protein proaerolysin remains a dimer at low concentrations in solution
10. Sphingolipid organization, what physical studies of model membranes reveal
11. Functions of lipid rafts in biological membranes
12. Protonation of His-132 promotes oligomerization of the channel-forming toxin Aerolysin
13. Conformational changes in aerolysin during the transition from the water-soluble protoxin to the membrane channel
14. Marker exchange mutagenesis of the aerolysin determinant in Aeromonas hydrophila demonstrates the role of aerolysin in A. hydrophila-associated infections
15. Aerolysin of Aeromonas sobria - Evidence for formation of ion-permeable channels and comparison with alpha-toxin of Staphylococcus aureus
16. Pathogenic analysis of Aeromonas hydrophila septicemia
17. The cytotoxic enterotoxin of Aeromonas hydrophila induces proinflammatory cytokine production and activates arachidonic acid metabolism in macrophages
18. Cytotoxic cell vacuolating activity from Vibrio cholerae hemolysin
19. Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement, bacterial factors, cellular ligands and signaling
20. Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane
21. Secretion and properties of the large and small lobes of the channel-forming toxin aerolysin
22. Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin Aerolysin
23. Expression and properties of an aerolysin - Clostridium septicum alpha toxin hybrid protein
24. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research
25. Dimer dissociation of the pore-forming toxin aerolysin precedes receptor binding
26. Hemolysin of Aeromonas sobria stimulates production of cyclic AMP by cultured cells
27. Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors
28. Alpha-Hemolysin from Staphylococcus aureus, an archetype of beta-barrel, channel-forming toxins
29. Site-directed mutagenesis of the hole-forming toxin Aerolysin - Studies on the roles of histidines in receptor binding and oligomerization of the monomer
30. Genetic dissection of the outer membrane secretin PulD, are there distinct domains for multimerization and secretion specificity?
31. Caveolae, DIGs, and the dynamics of shingolipid-cholesterol microdomains
32. Vibrio sp. secrete proaerolysin as a folded dimer without the need for disulfide bond formation
33. Cytotoxic action of Serratia marcescens hemolysin on human epithelial cells
34. Distribution of two hemolytic toxin genes in clinical and environmental isolates of Aeromonas spp.: Correlation with virulence in a suckling mouse model
35. Membrane glycoprotein receptor and hole forming properties of a cytolytic protein toxin
36. Activation of the hole forming toxin aerolysin by extracellular processing
37. Protein export by a gram-negative bacterium, production of aerolysin by Aeromonas hydrophila
38. Isolation and analysis of eight exe genes and their involvement in extracellular protein secretion and outer membrane assembly in Aeromonas hydrophila
39. A TonB-like protein and a novel membrane protein containing an ATP- binding cassette function together in exotoxin secretion
40. Isolation and characterization of a second exe operon required for extracellular protein secretion in Aeromonas hydrophila
41. Stimulation of neutrophil leukocyte chemotaxis by a cloned cytolytic enterotoxin of Aeromonas hydrophila
42. GPI-anchor synthesis in mammalian cells: Genes, their products, and a deficiency
43. Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytes
44. Increased stability upon heptamerization of the pore-forming toxin aerolysin
45. Membrane insertion, the strategy of toxins
46. Studies on the energetics of proaerolysin secretion across the outer membrane of Aeromonas species. Evidence for a requirement for both the protonmotive force and ATP
47. A specific targeting domain in mature exotoxin A is required for its extracellular secretion from Pseudomonas aeruginosa
48. Analysis of receptor binding by the channel-forming toxin aerolysin using surface plasmon resonance
49. The myristoyl-electrostatic switch, a modulator of reversible protein-membrane interactions
50. Cell vacuolation, a manifestation of the El tor hemolysin of vibrio cholerae
51. Characterization of the heptameric pore-forming complex of the Aeromonas toxin aerolysin using MALDI-TOF mass spectrometry
52. Channel formation by the glycosylphosphatidylinositol-anchored protein binding toxin aerolysin is not promoted by lipid rafts
53. The GPI-anchored surface glycoprotein Thy-1 is a receptor for the channel-forming toxin aerolysin
54. Channels formed by subnanomalar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas
55. Secretion of hemolysin of Aeromonas sobria as protoxin and contribution of the propeptide region removed from the protoxin to the proteolytic stability of the toxin
56. Carboxy terminal region of haemolysin of Aeromonas sobria triggers dimerization
57. Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states
58. Recent progress and future directions in studies of the main terminal branch of the general secretory pathway in Gram-negative bacteria-a review
59. Carbohydrate-binding proteins, tertiary structures and protein-sugar interactions
60. Towards deciphering the Helicobacter pylori cytotoxin
61. Aerolysin and pertussis toxin share a common receptor-binding domain
62. Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form
63. Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane
64. Lipid rafts and signal transduction
65. Structure of Staphylococcal α-hemolysin, a heptameric transmembrane pore
66. Homology between the seed cytolysin enterolobin and bacterial aerolysins
67. Optical single-channel analysis of the aerolysin pore in erythrocyte membranes
68. Staphylococcal alpha-toxin, repair of a calcium-impermeable pore in the target cell membrane
69. Engineering an enzyme to resist boiling
70. Identification and characterization of the aeromonas sobria hemolysin glycoprotein receptor on intestine 407 cells
71. The aerolysin membrane channel is formed by heptamerization of the monomer
72. Aerolysin, a hemolysin from Aeromonas hydrophila, forms voltage-gated channels in planar bilayers
73. Proton motive force involved in protein transport across the outer membrane of Aeromonas hydrophila
74. Pore-forming toxins
75. Dimerization stabilizes the pore-forming toxin aerolysin in solution
76. Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin, Identification of the site of proteolytic activation
77. Oligomerization of the channel-forming toxin Aerolysin precedes its insertion into lipid bilayer