Mesenchymal stem cells restore lung function by recruiting resident and nonresident proteins

Cell Transplantation

Volumn 20, Issue 10, 2011, Pages 1561-1574

  Jungebluth, Philipp ^a   Luedde, Mark ^b   Ferrer, Elisabet ^c   Luedde, Tom ^d   Vucur, Mihael ^d   Peinado, Victor I ^c   Go, Tetsuhiko ^e   Schreiber, Catharina ^f   von Richthofen, Maximilian ^f   Bader, Augustinus ^f   Haag, Johannes ^f   Darsow, Kai H ^f   Bartel, Sebastian J ^f   Lange, Harald A ^f   Furlani, Dario ^g   Steinhoff, Gustav ^g   Macchiarini, Paolo ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^e KAGAWA UNIVERSITY   (Japan)

^f Biomedical Biotechnological Center   (Germany)

^g UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Mesenchymal stem cells (MSCs); Protein expression; Pulmonary hypertension; Stromal derived factor 1

Indexed keywords

CASPASE 3; CHEMOKINE RECEPTOR CXCR4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYOSIN LIGHT CHAIN; PROTEOME; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL THERAPY; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; LUNG FUNCTION; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE;

RATTUS;

EID: 82855181756     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X557254     Document Type: Article

References (46)

1. Aggarwal, S.; Pittenger, M. F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822; 2005.
2. Baber, S. R.; Deng, W.; Master, R. G.; Bunnell, B. A.; Taylor, B. K.; Murthy, S. N.; Hyman, A. L.; Kadowitz, P. J. Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 292:H1120-1128; 2007.
3. Blum, H.; Beier, H.; Gross, H. J. Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels. Electrophoresis 8:93-99; 1987.
4. Bonderman, D.; Jakowitsch, J.; Adlbrecht, C.; Schemper, M.; Kyrle, P. A.; Schonauer, V.; Exner, M.; Klepetko, W.; Kneussl, M. P.; Maurer, G.; Lang, I. Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension. Thromb. Haemost. 93:512-516; 2005.
5. Cho, S. R.; Kim, Y. R.; Kang, H. S.; Yim, S. H.; Park, C. I.; Min, Y. H.; Lee, B. H.; Shin, J. C.; Lim, J. B. Functional recovery after the transplantation of neurally differentiated mesenchymal stem cells derived from bone barrow in a rat model of spinal cord injury. Cell Transplant. 18:1359-1368; 2009.
6. Doroszko, A.; Hurst, T. S.; Polewicz, D.; Sawicka, J.; Fert-Bober, J.; Johnson, D. H.; Sawicki, G. Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury. Proteome Sci. 8:3; 2010.
7. Feinstein, J. A.; Goldhaber, S. Z.; Lock, J. E.; Ferndandes, S. M.; Landzberg, M. J. Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension. Circulation 103:10-13; 2001.
8. Florea, L.; Di Francesco, V.; Miller, J.; Turner, R.; Yao, A.; Harris, M.; Walenz, B.; Mobarry, C.; Merkulov, G. V.; Charlab, R.; Dew, I.; Deng, Z.; Istrail, S.; Li, P.; Sutton, G. Gene and alternative splicing annotation with AIR. Genome Res. 15:54-66; 2005.
9. Furlani, D.; Li, W.; Pittermann, E.; Klopsch, C.; Wang, L.; Knopp, A.; Jungebluth, P.; Thedinga, E.; Havenstein, C.; Westien, I.; Ugurlucan, M.; Li, R. K.; Ma, N.; Steinhoff, G. A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart. Cell Transplant. 18:319-331; 2009.
10. Gupta, N.; Su, X.; Popov, B.; Lee, J. W.; Serikov, V.; Matthay, M. A. Intrapulmonary delivery of bone marrowderived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J. Immunol. 179:1855-1863; 2007.
11. Hagl, C.; Khaladj, N.; Peters, T.; Hoeper, M. M.; Logemann, F.; Haverich, A.; Macchiarini, P. Technical advances of pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Eur. J. Cardiothorac. Surg. 23:776-781; discussion 781; 2003.
12. Hoeper, M. M.; Mayer, E.; Simonneau, G.; Rubin, L. J. Chronic thromboembolic pulmonary hypertension. Circulation 113:2011-2020; 2006.
13. Jamieson, S. W.; Kapelanski, D. P.; Sakakibara, N.; Manecke, G. R.; Thistlethwaite, P. A.; Kerr, K. M.; Channick, R. N.; Fedullo, P. F.; Auger, W. R. Pulmonary endarterectomy: Experience and lessons learned in 1,500 cases. Ann. Thorac. Surg. 76:1457-1462; discussion 1462-1464; 2003.
14. Jungebluth, P.; Ostertag, H.; Macchiarini, P. An experimental animal model of postobstructive pulmonary hypertension. J. Surg. Res. 147:75-78; 2008.
15. Kim, N. H. Assessment of operability in chronic thromboembolic pulmonary hypertension. Proc. Am. Thorac. Soc. 3:584-588; 2006.
16. Klepetko, W.; Mayer, E.; Sandoval, J.; Trulock, E. P.; Vachiery, J. L.; Dartevelle, P.; Pepke-Zaba, J.; Jamieson, S. W.; Lang, I.; Corris, P. Interventional and surgical modalities of treatment for pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43:73S-80S; 2004.
17. Klose, J.; Kobalz, U. Two-dimensional electrophoresis of proteins: an updated protocol and implications for a functional analysis of the genome. Electrophoresis 16:1034-1059; 1995.
18. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685; 1970.
19. Luedde, T.; Trautwein, C. Intracellular survival pathways in the liver. Liver Int. 26:1163-1174; 2006.
20. Macchiarini, P.; Jungebluth, P.; Go, T.; Asnaghi, M. A.; Rees, L. E.; Cogan, T. A.; Dodson, A.; Martorell, J.; Bellini, S.; Parnigotto, P. P.; Dickinson, S. C.; Hollander, A. P.; Mantero, S.; Conconi, M. T.; Birchall, M. A. Clinical transplantation of a tissue-engineered airway. Lancet 372:2023-2030; 2008.
21. Macchiarini, P.; Kamiya, H.; Hagl, C.; Winterhalter, M.; Barbera, J.; Karck, M.; Pomar, J.; Haverich, A. Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: Is deep hypothermia required? Eur. J. Cardiothorac. Surg. 30:237-241; discussion 241-243; 2006.
22. Mathew, R.; Huang, J.; Shah, M.; Patel, K.; Gewitz, M.; Sehgal, P. B. Disruption of endothelial-cell caveolin1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension. Circulation 110: 1499-1506; 2004.
23. Mathew, R.; Zeballos, G. A.; Tun, H.; Gewitz, M. H. Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats. Cardiovasc. Res. 30:739-746; 1995.
24. McLaughlin, V. V.; Archer, S. L.; Badesch, D. B.; Barst, R. J.; Farber, H. W.; Lindner, J. R.; Mathier, M. A.; McGoon, M. D.; Park, M. H.; Rosenson, R. S.; Rubin, L. J.; Tapson, V. F.; Varga, J. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J. Am. Coll. Cardiol. 53:1573-1619; 2009.
25. McNally, E. M.; Gianola, K. M.; Leinwand, L. A. Complete nucleotide sequence of full length cDNA for rat alpha cardiac myosin heavy chain. Nucleic Acids Res. 17: 7527-7528; 1989.
26. Mueller, E. C.; Schumann, M.; Rickers, A.; Bommert, K.; Wittmann-Liebold, B.; Otto, A. Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry. Electrophoresis 20:320-330; 1999.
27. Ortiz, L. A.; Gambelli, F.; McBride, C.; Gaupp, D.; Baddoo, M.; Kaminski, N.; Phinney, D. G. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc. Natl. Acad. Sci. USA 100:8407-8411; 2003.
28. Pan, J. J.; Oh, S. H.; Lee, W. C.; Petersen, B. E. Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model. Oncol. Res. 17:339-345; 2009.
29. Pappin, D. J.; Hojrup, P.; Bleasby, A. J. Rapid identification of proteins by peptide-mass fingerprinting. Curr. Biol. 3:327-332; 1993.
30. Pengo, V.; Lensing, A. W.; Prins, M. H.; Marchiori, A.; Davidson, B. L.; Tiozzo, F.; Albanese, P.; Biasiolo, A.; Pegoraro, C.; Iliceto, S.; Prandoni, P. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N. Engl. J. Med. 350:2257-2264; 2004.
31. Peter, Y. Tracheotomy: A method for transplantation of stem cells to the lung. J. Vis. Exp. 163; 2007.
32. Pittenger, M. F.; Mackay, A. M.; Beck, S. C.; Jaiswal, R. K.; Douglas, R.; Mosca, J. D.; Moorman, M. A.; Simonetti, D. W.; Craig, S.; Marshak, D. R. Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147; 1999.
33. Popp, F. C.; Piso, P.; Schlitt, H. J.; Dahlke, M. H. Therapeutic potential of bone marrow stem cells for liver diseases. Curr. Stem Cell Res. Ther. 1:411-418; 2006.
34. Prockop, D. J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71-74; 1997.
35. Rojas, M.; Xu, J.; Woods, C. R.; Mora, A. L.; Spears, W.; Roman, J.; Brigham, K. L. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am. J. Respir. Cell Mol. Biol. 33:145-152; 2005.
36. Simonneau, G.; Robbins, I. M.; Beghetti, M.; Channick, R. N.; Delcroix, M.; Denton, C. P.; Elliott, C. G.; Gaine, S. P.; Gladwin, M. T.; Jing, Z. C.; Krowka, M. J.; Langleben, D.; Nakanishi, N.; Souza, R. Updated clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 54:S43-54; 2009.
37. Sun, B.; Roh, K. H.; Park, J. R.; Lee, S. R.; Park, S. B.; Jung, J. W.; Kang, S. K.; Lee, Y. S.; Kang, K. S. Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy 11:289-298; 2009.
38. Takahashi, M.; Nakamura, T.; Toba, T.; Kajiwara, N.; Kato, H.; Shimizu, Y. Transplantation of endothelial progenitor cells into the lung to alleviate pulmonary hypertension in dogs. Tissue Eng. 10:771-779; 2004.
39. Takemiya, K.; Kai, H.; Yasukawa, H.; Tahara, N.; Kato, S.; Imaizumi, T. Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats. Basic Res. Cardiol. 105:409-417; 2010.
40. Tapson, V. F.; Humbert, M. Incidence and prevalence of chronic thromboembolic pulmonary hypertension: from acute to chronic pulmonary embolism. Proc. Am. Thorac. Soc. 3:564-567; 2006.
41. Umar, S.; de Visser, Y. P.; Steendijk, P.; Schutte, C. I.; Laghmani el, H.; Wagenaar, G. T.; Bax, W. H.; Mantikou, E.; Pijnappels, D. A.; Atsma, D. E.; Schalij, M. J.; van der Wall, E. E.; van der Laarse, A. Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension. Am. J. Physiol. Heart Circ. Physiol. 297:H1606-1616; 2009.
42. Venter, J. C.; Celera Genomics Group; et al. The sequence of the human genome. Science 291:1304-1351; 2001.
43. Wang, W.; Li, W.; Ong, L. L.; Lutzow, K.; Lendlein, A.; Furlani, D.; Gabel, R.; Kong, D.; Wang, J.; Li, R. K.; Steinhoff, G.; Ma, N. Localized and sustained SDF-1 gene release mediated by fibronectin films: A potential method for recruiting stem cells. Int. J. Artif. Organs 32:141-149; 2009.
44. Xu, W. T.; Bian, Z. Y.; Fan, Q. M.; Li, G.; Tang, T. T. Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Cancer Lett. 18:32-41; 2009.
45. Zhao, Y. D.; Courtman, D. W.; Deng, Y.; Kugathasan, L.; Zhang, Q.; Stewart, D. J. Rescue of monocrotalineinduced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease. Circ. Res. 96:442-450; 2005.
46. Zheng, H.; Fu, G.; Dai, T.; Huang, H. Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway. J. Cardiovasc. Pharmacol. 50:274-280; 2007.