A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart

Cell Transplantation

Volumn 18, Issue 3, 2009, Pages 319-331

  Furlani, Dario ^a   Li, Wenzhong ^a   Pittermann, Erik ^a   Klopsch, Christian ^a   Wang, Liang ^a   Knopp, Agnes ^a   Jungebluth, Philipp ^b   Thedinga, Elke ^c   Havenstein, Carolin ^a   Westien, Ingeborg ^a   Ugurlucan, Murat ^a   Li, Ren Ke ^d   Ma, Nan ^a   Steinhoff, Gustav ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b UNIVERSITY OF BARCELONA   (Spain)

^c Bionas GmbH   (Germany)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Mesenchymal stem cells; Regeneration; Transformation; Transplantation

Indexed keywords

BETA1 INTEGRIN; HERMES ANTIGEN; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN;

ACUTE HEART INFARCTION; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL AGGREGATION; CELL CULTURE; CELL DIVISION; CELL ISOLATION; CELL METABOLISM; CELL POPULATION; CELL STRUCTURE; CELL TRANSFORMATION; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; HEART FUNCTION; HEART INFARCTION SIZE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOPHENOTYPING; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NUMERICAL CHROMOSOME ABERRATION; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; BIOLOGICAL MARKERS; CELL LINE, TRANSFORMED; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES, MAMMALIAN; HEART FUNCTION TESTS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS;

RATTUS;

EID: 67449107988     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368909788534906     Document Type: Article

References (27)

1. Aguilar, S.; Nye, E.; Chan, J.; Loebinger, M.; Spencer-Dene, B.; Fisk, N.; Stamp, G.; Bonnet, D.; Janes, S. M. Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells 25(6):1586-1594; 2007.
2. Alvarez-Dolado, M.; Pardal, R.; Garcia-Vardugo, J. M.; Fike, J. R.; Lee, H. O.; Pfeffer, K.; Lois, C.; Morrison, S. J.; Alvarez-Buylla, A. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425(6961):968-973; 2003.
3. Dexter, T. M.; Allen, T. D.; Lajtha, L. G. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J. Cell. Physiol. 91(3):335-344; 1977.
4. Docheva, D.; Padula, D.; Popov, C.; Mutschler, W.; Clausen-Schaumann, H.; Schieker, M. Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy. J. Cell. Mol. Med. 12(2):537-552; 2008.
5. Iop, L.; Chiavegato, A.; Callegari, A.; Bollini, S.; Piccoli, M.; Pozzobon, M.; Rossi, C. A.; Calamelli, S.; Chiavegato, D.; Gerosa, G.; De Coppi, P.; Sartore, S. Different cardiovascular potential of adult- and fetal-type mesenchymal stem cells in a rat model of heart cryoinjury. Cell Transplant. 17(6):679-694; 2008.
6. Jiang, Y.; Jahagirdar, B. N.; Reinhardt, R. L.; Schwartz, R. E.; Keene, C. D.; Ortiz-Gonzalez, X. R.; Reyes, M.; Lenvik, T.; Lund, T.; Blackstad, M.; Du, J.; Aldrich, S.; Lisberg, A.; Low, W. C.; Largaespada, D. A.; Verfaillie, C. M. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418(6893):41-49; 2002.
7. Kotobuki, N.; Katsube, Y.; Katou, Y.; Tadokoro, M.; Hirose, M.; Ohgushi, H. In vivo survival and osteogenic differentiation of allogeneic rat bone marrow mesenchymal stem cells (MSCs). Cell Transplant. 17(6):705-712; 2008.
8. Li, H.; Fan, X.; Kovi, R. C.; Jo, Y.; Moquin, B.; Konz, R.; Stoicov, C.; Kurt-Jones, E.; Grossman, S. R.; Lyle, S.; Rogers, A. B.; Montrose, M.; Houghton, J. Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: A model of age-related tumorigenesis in mice. Cancer Res. 67(22):10889-10898; 2007. (Pubitemid 350145918)
9. Li, W.; Ma, N.; Ong, L. L.; Nesselmann, C.; Klopsch, C.; Ladilov, Y.; Furlani, D.; Piechaczek, C.; Moebius, J. M.; Lützow, K.; Lendlein, A.; Stamm, C.; Li, R. K.; Steinhoff, G. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells 25(8):2118-2127; 2007. (Pubitemid 47258191)
10. Makino, S.; Fukuda, K.; Miyoshi, S.; Konishi, F.; Kodama, H.; Pan, J.; Sano, M.; Takahashi, T.; Hori, S.; Abe, H.; Hata, J.; Umezawa, A.; Ogawa, S. Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103(5):697-705; 1999.
11. Miura, M.; Miura, Y.; Padilla-Nash, H. M.; Molinolo, A. A.; Fu, B.; Patel, V.; Seo, B. M.; Sonoyama, W.; Zheng, J. J.; Baker, C. C.; Chen, W.; Ried, T.; Shi, S. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 24(4):1095-1103; 2006. (Pubitemid 44464742)
12. Nesselmann, C.; Ma, N.; Bieback, K.; Wagner, W.; Ho, A.; Konttinen, Y. T.; Zhang, H.; Hinescu, M. E.; Steinhoff, G. Mesenchymal stem cells and cardiac repair. J. Cell. Mol. Med. 12(5B):1785-1810; 2008.
13. Penna, C.; Raimondo, S.; Ronchi, G.; Rastaldo, R.; Mancardi, D.; Cappello, S.; Losano, G.; Geuna, S.; Pagliaro, P. Early homing of adult mesenchymal stem cells in normal and infarcted isolated beating hearts. J. Cell. Mol. Med. 12(2):507-521; 2008.
14. Pittenger, M. F.; Mackay, A. M.; Beck, S. C.; Jaiswal, R. K.; Douglas, R.; Mosca, J. D.; Moorman, M. A.; Simonetti, D. W.; Craig, S.; Marshak, D. R. Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143-147; 1999.
15. Prockop, D. J.; Olson, S. D. Clinical trials with adult stem/progenitor cells for tissue repair: Let's not overlook some essential precautions. Blood 109(8):3147-3151; 2007.
16. Rubio, D.; Garcia-Castro, J.; Martin, M. C.; de la Fuente, R.; Cigudosa, J. C.; Lloyd, A. C.; Bernad, A. Spontaneous human adult stem cell transformation. Cancer Res. 65(8):3035-3039; 2005. (Pubitemid 40524580)
17. Shiras, A.; Chettiar, S. T.; Shepal, V.; Rajendran, G.; Prasad, G. R.; Shastry, P. Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells 25(6):1478-1489; 2007.
18. Spees, J. L.; Olson, S. D.; Ylostalo, J.; Lynch, P. J.; Smith, J.; Perry, A.; Peister, A.; Wang, M. Y.; Prockop, D. J. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc. Natl. Acad. Sci. USA 100(5):2397-2402; 2003.
19. Tateishi, K.; Ando, W.; Higuchi, C.; Hart, D. A.; Hashimoto, J.; Nakata, K.; Yoshikawa, H.; Nakamura, N. Comparison of human serum with fetal bovine serum for expansion and differentiation of human synovial MSC: Potential feasibility for clinical applications. Cell Transplant. 17(5):549-557; 2008.
20. Tjabringa, G. S.; Zandieh-Doulabi, B.; Helder, M. N.; Knippenberg, M.; Wuisman, P. I.; Klein-Nulend, J. The polymine spermine regulates osteogenic differentiation in adipose stem cells. J. Cell. Mol. Med. 12(5A):1710-1717; 2008.
21. Tolar, J.; Nauta, A. J.; Osborn, M. J.; Panoskaltsis, M. A.; McElmurry, R. T.; Bell, S.; Xia, L.; Zhou, N.; Riddle, M.; Schroeder, T. M.; Westendorf, J. J.; McIvor, R. S.; Hogendoorn, P. C.; Szuhai, K.; Oseth, L.; Hirsch, B.; Yant, S. R.; Kay, M. A.; Peister, A.; Prockop, D. J.; Fibbe, W. E.; Blazar, B. R. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells 25(2):371-379; 2007.
22. Toma, C.; Pittenger, M. F.; Cahill, K. S.; Byrne, B. J.; Kessler, P. D. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105(1):93-98; 2002.
23. Vassilopoulos, G.; Wang, P. R.; Russell, D. W. Transplanted bone marrow regenerates liver by cell fusion. Nature 422(6934):901-904; 2003.
24. Wang, X.; Willenbring, H.; Akkari, Y.; Torimaru, Y.; Foster, M.; Al-Dhalimy, M.; Lagasse, E.; Finegold, M.; Olson, S.; Grompe, M. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422(6934):897-901; 2003. (Pubitemid 36520042)
25. Wang, Y.; Huso, D. L.; Harrington, J.; Kellner, J.; Jeong, D. K.; Turney, J.; McNiece, I. K. Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. Cytotherapy 7(6):509-519; 2005.
26. Wu, J.; Sun, Z.; Sun, H. S.; Wu, J.; Weisel, R. D.; Keating, A.; Li, Z. H.; Feng, Z. P.; Li, R. K. Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats. Cell Transplant. 16(10):993-1005; 2007.
27. Zhou, Y. F.; Bosch-Marce, M.; Okuyama, H.; Krishnamachary, B.; Kimura, H.; Zhang, L.; Huso, D. L.; Semenza, G. L. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res. 66(22):10849-10854; 2006.