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Volumn 45, Issue 5, 2011, Pages 489-499

The role of ecto-purines in inflammation leading to demyelination - new means for therapies against multiple sclerosis;Rola ektopuryn w procesie od zapalenia do demielinizacji - perspektywy powstania nowych metod leczenia stwardnienia rozsianego

Author keywords

Demyelination; Ecto purines; Ecto pyrimidines; Immunosuppression; Inflammation

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CHEMOKINE; CYTOKINE; NUCLEOTIDE; PURINERGIC P2 RECEPTOR;

EID: 82855165257     PISSN: 00283843     EISSN: 18974260     Source Type: Journal    
DOI: 10.1016/s0028-3843(14)60318-2     Document Type: Article
Times cited : (6)

References (72)
  • 1
    • 0038240048 scopus 로고    scopus 로고
    • Inflammation in multiple sclerosis: The good, the bad, and the complex
    • i wsp
    • Martino G., Adorini L., Rieckmann P. i wsp. Inflammation in multiple sclerosis: the good, the bad, and the complex. Lancet Neurol 2002; 1: 499-509.
    • (2002) Lancet Neurol , vol.1 , pp. 499-509
    • Martino, G.1    Adorini, L.2    Rieckmann, P.3
  • 2
    • 77950862182 scopus 로고    scopus 로고
    • Multiple sclerosis - candidate mechanisms underlying CNS atrophy
    • i wsp
    • Siffrin V., Vogt J., Radbruch H. i wsp. Multiple sclerosis - candidate mechanisms underlying CNS atrophy. Trends Neurosci 2010; 33: 202-210.
    • (2010) Trends Neurosci , vol.33 , pp. 202-210
    • Siffrin, V.1    Vogt, J.2    Radbruch, H.3
  • 3
    • 33947700320 scopus 로고    scopus 로고
    • Purinergic signaling in the immune system. A brief update
    • Di Virgilio F. Purinergic signaling in the immune system. A brief update. Purinergic Signal 2007; 3: 1-3.
    • (2007) Purinergic Signal , vol.3 , pp. 1-3
    • di Virgilio, F.1
  • 4
    • 58949094359 scopus 로고    scopus 로고
    • Purinergic signalling in inflammation of the central nervous system
    • i wsp
    • Di Virgilio F., Ceruti S., Bramanti P. i wsp. Purinergic signalling in inflammation of the central nervous system. Trends Neurosci 2009; 2: 79-87.
    • (2009) Trends Neurosci , vol.2 , pp. 79-87
    • di Virgilio, F.1    Ceruti, S.2    Bramanti, P.3
  • 5
    • 33947647866 scopus 로고    scopus 로고
    • Purinergic modulation of microglial cell activation
    • Sperlagh B., Illes P. Purinergic modulation of microglial cell activation. Purinergic Signal 2007; 3: 117-127.
    • (2007) Purinergic Signal , vol.3 , pp. 117-127
    • Sperlagh, B.1    Illes, P.2
  • 6
    • 32744464601 scopus 로고    scopus 로고
    • E-NTPDazy - enzymy uczestnicza{ogonek}ce w procesach sygnalizacji w centralnym układzie nerwowym
    • Kukulski F., Komoszyński M. E-NTPDazy - enzymy uczestnicza{ogonek}ce w procesach sygnalizacji w centralnym układzie nerwowym. Postepy Biol Komorki 2002; 3: 449-463.
    • (2002) Postepy Biol Komorki , vol.3 , pp. 449-463
    • Kukulski, F.1    Komoszyński, M.2
  • 7
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science 2002; 296: 301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 8
    • 33749261659 scopus 로고    scopus 로고
    • Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
    • i wsp
    • Bours M., Swennen E., Serafini B. i wsp. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther 2006; 112: 358-404.
    • (2006) Pharmacol Ther , vol.112 , pp. 358-404
    • Bours, M.1    Swennen, E.2    Serafini, B.3
  • 9
    • 41949083203 scopus 로고    scopus 로고
    • Nucleotide and nucleoside converting ectoenzymes: Important modulators of purinergic signalling cascade
    • Yegutkin G. Nucleotide and nucleoside converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim Biophys Acta 2008; 1783: 673-694.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 673-694
    • Yegutkin, G.1
  • 10
    • 74449084314 scopus 로고    scopus 로고
    • Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro
    • i wsp
    • Kukulski F., Ben Yebdri F., Bahrami F. i wsp. Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro. Mol Immunol 2010; 47: 991-999.
    • (2010) Mol Immunol , vol.47 , pp. 991-999
    • Kukulski, F.1    Ben Yebdri, F.2    Bahrami, F.3
  • 11
    • 33947675761 scopus 로고    scopus 로고
    • P2 purinergic receptor modulation of cytokine production
    • Gabel Ch. P2 purinergic receptor modulation of cytokine production. Purinergic Signal 2007; 3: 27-38.
    • (2007) Purinergic Signal , vol.3 , pp. 27-38
    • Gabel, C.1
  • 12
    • 26444450583 scopus 로고    scopus 로고
    • P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells
    • i wsp
    • Wang L., Jacobsen S., Bengtsson A. i wsp. P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells. BMC Immunol 2004; 5: 1-7.
    • (2004) BMC Immunol , vol.5 , pp. 1-7
    • Wang, L.1    Jacobsen, S.2    Bengtsson, A.3
  • 13
    • 19544391973 scopus 로고    scopus 로고
    • The "danger" sensors that STOP the immune response: The A2 adenosine receptors?
    • Sitkovsky M.V., Ohta A. The "danger" sensors that STOP the immune response: the A2 adenosine receptors? Trends Immunol 2005; 22: 299-304.
    • (2005) Trends Immunol , vol.22 , pp. 299-304
    • Sitkovsky, M.V.1    Ohta, A.2
  • 14
    • 2542432162 scopus 로고    scopus 로고
    • Physiological control of immune response and inflammatory tissue damage by hypoxia- inducible factors and adenosine A2A receptors
    • i wsp
    • Sitkovsky M., Lukashev D., Apasov S. i wsp. Physiological control of immune response and inflammatory tissue damage by hypoxia- inducible factors and adenosine A2A receptors. Annu Rev Immunol 2004; 22: 657-682.
    • (2004) Annu Rev Immunol , vol.22 , pp. 657-682
    • Sitkovsky, M.1    Lukashev, D.2    Apasov, S.3
  • 16
    • 62349114041 scopus 로고    scopus 로고
    • Extracellular ATP in immune system: More than a just a danger signal
    • Trautmann A. Extracellular ATP in immune system: more than a just a danger signal. Sci Signal 2009; 2: 1-3.
    • (2009) Sci Signal , vol.2 , pp. 1-3
    • Trautmann, A.1
  • 17
    • 84888466345 scopus 로고
    • Zmiany ste{ogonek}żenia wolnych nukleotydów adeninowych w erytrocytach i aktywno oeci ATP-azowej cieni krwinek czerwonych chorych na stwardnienie rozsiane leczonych ACTH
    • i wsp
    • Chmielewski H., Maciejek Z., Lutz W. i wsp. Zmiany ste{ogonek}żenia wolnych nukleotydów adeninowych w erytrocytach i aktywno oeci ATP-azowej cieni krwinek czerwonych chorych na stwardnienie rozsiane leczonych ACTH. Biuletyn WAM 1980; 23: 71-78.
    • (1980) Biuletyn WAM , vol.23 , pp. 71-78
    • Chmielewski, H.1    Maciejek, Z.2    Lutz, W.3
  • 18
    • 34248576759 scopus 로고    scopus 로고
    • Physiology and pathophysiology of purinergic neurotransmission
    • Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 2007; 87: 659-797.
    • (2007) Physiol Rev , vol.87 , pp. 659-797
    • Burnstock, G.1
  • 19
    • 0035313093 scopus 로고    scopus 로고
    • Purine-mediated signaling in pain and visceral perception
    • Burnstock G. Purine-mediated signaling in pain and visceral perception. Trends Pharmacol Sci 2001; 4: 182-188.
    • (2001) Trends Pharmacol Sci , vol.4 , pp. 182-188
    • Burnstock, G.1
  • 20
    • 0015393308 scopus 로고
    • Purinergic nerves
    • Burnstock G. Purinergic nerves. Pharmacol Rev 1972; 24: 509-581.
    • (1972) Pharmacol Rev , vol.24 , pp. 509-581
    • Burnstock, G.1
  • 21
    • 0028175838 scopus 로고
    • Interleukin1B maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity
    • Perregaux D., Gabel C.A. Interleukin1B maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 1994; 269: 15195-15203.
    • (1994) J Biol Chem , vol.269 , pp. 15195-15203
    • Perregaux, D.1    Gabel, C.A.2
  • 22
    • 0037092429 scopus 로고    scopus 로고
    • ADP and AMP induce interleukin1- β release from microglial cells through activation of ATP-primed P2X7 receptor channel
    • i wsp
    • Chakfe Y., Seguin R., Antel J. i wsp. ADP and AMP induce interleukin1- β release from microglial cells through activation of ATP-primed P2X7 receptor channel. J Neurosci 2002; 22: 3061-3069.
    • (2002) J Neurosci , vol.22 , pp. 3061-3069
    • Chakfe, Y.1    Seguin, R.2    Antel, J.3
  • 23
    • 0037443419 scopus 로고    scopus 로고
    • Secretion of IL-2 and IFNgamma but not IL-4 by antigen-specific T cells requires extracellular ATP
    • i wsp
    • Langston H., Ke Y., Gewirtz A. i wsp. Secretion of IL-2 and IFNgamma but not IL-4 by antigen-specific T cells requires extracellular ATP. J Immunol 2003; 170: 2962-2970.
    • (2003) J Immunol , vol.170 , pp. 2962-2970
    • Langston, H.1    Ke, Y.2    Gewirtz, A.3
  • 24
    • 60449100436 scopus 로고    scopus 로고
    • Selective P2X7 receptor antagonists for chronic inflammation and pain
    • Carroll W., Donnelly-Roberts D., Jarvis M. Selective P2X7 receptor antagonists for chronic inflammation and pain. Purinergic Signal 2009; 5: 63-73.
    • (2009) Purinergic Signal , vol.5 , pp. 63-73
    • Carroll, W.1    Donnelly-Roberts, D.2    Jarvis, M.3
  • 25
    • 76149099290 scopus 로고    scopus 로고
    • The P2X7 purinergic receptor: From physiology to neurological disorders
    • Skaper S., Debetto P., Giusti P. The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB J 2009; 24: 337-345.
    • (2009) FASEB J , vol.24 , pp. 337-345
    • Skaper, S.1    Debetto, P.2    Giusti, P.3
  • 26
    • 33645224970 scopus 로고    scopus 로고
    • COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    • i wsp
    • Yiangou Y., Facer P., Durrenberger P. i wsp. COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol 2006; 2: 6-12.
    • (2006) BMC Neurol , vol.2 , pp. 6-12
    • Yiangou, Y.1    Facer, P.2    Durrenberger, P.3
  • 27
    • 0037440567 scopus 로고    scopus 로고
    • P2X7 Receptor-mediated release of excitatory amino acid from astrocytes
    • i wsp
    • Duan S., Anderson C.M., Keung E.C. i wsp. P2X7 Receptor-mediated release of excitatory amino acid from astrocytes. J Neurosci 2003; 23: 1320-1328.
    • (2003) J Neurosci , vol.23 , pp. 1320-1328
    • Duan, S.1    Anderson, C.M.2    Keung, E.C.3
  • 28
    • 33947663623 scopus 로고    scopus 로고
    • The role of purinergic P2X7 receptor in inflammation
    • i wsp
    • Lister M., Sharkey J., Sawatzky D. i wsp. The role of purinergic P2X7 receptor in inflammation. J Inflammation 2007; 4: 5.
    • (2007) J Inflammation , vol.4 , pp. 5
    • Lister, M.1    Sharkey, J.2    Sawatzky, D.3
  • 30
    • 13244299100 scopus 로고    scopus 로고
    • The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes
    • i wsp
    • Narcisse L., Scemes E., Zhao Y. i wsp. The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes. Glia 2005; 49: 245-258.
    • (2005) Glia , vol.49 , pp. 245-258
    • Narcisse, L.1    Scemes, E.2    Zhao, Y.3
  • 31
    • 77449148016 scopus 로고    scopus 로고
    • Recent patents on P2X(7) receptor antagonist and their potential for reducing central nervous system inflammation
    • Friedle S.A., Curet M.A., Watters J.J. Recent patents on P2X(7) receptor antagonist and their potential for reducing central nervous system inflammation. Recent Pat CNS Drug Discov 2010; 5: 35-45.
    • (2010) Recent Pat CNS Drug Discov , vol.5 , pp. 35-45
    • Friedle, S.A.1    Curet, M.A.2    Watters, J.J.3
  • 32
    • 10744232557 scopus 로고    scopus 로고
    • Hit-to-lead studies: The discovery of potent adamantine amid P2X7 receptor antagonist
    • i wsp
    • Baxter A., Bent J., Bowers K. i wsp. Hit-to-lead studies: the discovery of potent adamantine amid P2X7 receptor antagonist. Bioorg Med Chem Lett 2003; 13: 4047-4050.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 4047-4050
    • Baxter, A.1    Bent, J.2    Bowers, K.3
  • 33
    • 15544370681 scopus 로고    scopus 로고
    • Recent progress in the discovery of antagonists acting at P2X7 receptor
    • Romagnoli R., Baraldi P.G., Di Virgillo F. Recent progress in the discovery of antagonists acting at P2X7 receptor. Expert Opin Ther Pat 2005; 15: 271-287.
    • (2005) Expert Opin Ther Pat , vol.15 , pp. 271-287
    • Romagnoli, R.1    Baraldi, P.G.2    di Virgillo, F.3
  • 34
    • 13544251389 scopus 로고    scopus 로고
    • Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression n human dendritic cells: A novel role for the cAMP pathway
    • i wsp
    • Schnurr M., Toy T., Shin A. i wsp. Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression n human dendritic cells: a novel role for the cAMP pathway. Blood 2005; 105: 1582-1589.
    • (2005) Blood , vol.105 , pp. 1582-1589
    • Schnurr, M.1    Toy, T.2    Shin, A.3
  • 35
    • 0035979725 scopus 로고    scopus 로고
    • P2Y(11) receptor expression by human lymphocytes: Evidence for two cAMPlinked purinorceptors
    • i wsp
    • Conigrave A.D., Fernando K.C., Gu B. i wsp. P2Y(11) receptor expression by human lymphocytes: evidence for two cAMPlinked purinorceptors. Eur J Pharmacol 2001; 426: 157-163.
    • (2001) Eur J Pharmacol , vol.426 , pp. 157-163
    • Conigrave, A.D.1    Fernando, K.C.2    Gu, B.3
  • 36
    • 57349085127 scopus 로고    scopus 로고
    • Diastereoselectivity of the P2Y11 nucleotide receptor: Mutation analysis
    • Ecke D., Fischer B., Reiser G. Diastereoselectivity of the P2Y11 nucleotide receptor: mutation analysis. Br J Pharmacol 2008; 155: 1250-1255.
    • (2008) Br J Pharmacol , vol.155 , pp. 1250-1255
    • Ecke, D.1    Fischer, B.2    Reiser, G.3
  • 37
    • 4744352568 scopus 로고    scopus 로고
    • Invovement of multiple P2Y receptors and signaling pathways in the action of adenine nucleoside diphosphates on human monocyte-derived dendritic cells
    • i wsp
    • Marteau F., Comni D., Boeynaems J.-M. i wsp. Invovement of multiple P2Y receptors and signaling pathways in the action of adenine nucleoside diphosphates on human monocyte-derived dendritic cells. J Leukoc Biol 2004; 76: 796-803.
    • (2004) J Leukoc Biol , vol.76 , pp. 796-803
    • Marteau, F.1    Comni, D.2    Boeynaems, J.-M.3
  • 39
    • 70349331090 scopus 로고    scopus 로고
    • Adenosine receptors and neurological disease: Neuroprotection and neurodegeneration
    • Stone T.W., Cerutti S., Abbracchio M.P. Adenosine receptors and neurological disease: neuroprotection and neurodegeneration. Handb Exp Pharmacol 2009; 193: 535-587.
    • (2009) Handb Exp Pharmacol , vol.193 , pp. 535-587
    • Stone, T.W.1    Cerutti, S.2    Abbracchio, M.P.3
  • 40
    • 74849125021 scopus 로고    scopus 로고
    • Activities of the enzymes that hydrolyze adenine nucleotides in platelets from multiple sclerosis patients
    • i wsp
    • Spanevello R.M., Mazzanti C.M., Bagatini M. i wsp. Activities of the enzymes that hydrolyze adenine nucleotides in platelets from multiple sclerosis patients. J Neurol 2010; 257: 24-30.
    • (2010) J Neurol , vol.257 , pp. 24-30
    • Spanevello, R.M.1    Mazzanti, C.M.2    Bagatini, M.3
  • 41
    • 33947660450 scopus 로고    scopus 로고
    • P1 receptors and cytokine secretion
    • Abbracchio M., Ceruti S. P1 receptors and cytokine secretion. Purinergic Signal 2007; 3: 13-25.
    • (2007) Purinergic Signal , vol.3 , pp. 13-25
    • Abbracchio, M.1    Ceruti, S.2
  • 42
    • 1242336753 scopus 로고    scopus 로고
    • A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelinination in a model of multiple sclerosis
    • i wsp
    • Tsutsui S., Schnermann J., Noorbakhsh F. i wsp. A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelinination in a model of multiple sclerosis. J Neurosci 2004; 24: 1521-1529.
    • (2004) J Neurosci , vol.24 , pp. 1521-1529
    • Tsutsui, S.1    Schnermann, J.2    Noorbakhsh, F.3
  • 43
    • 0030931501 scopus 로고    scopus 로고
    • Focal cerebral ischemia enhances glial expression of ecto-5'-nucleotidase
    • i wsp
    • Braun N., Lenz C., Gillardon F. i wsp. Focal cerebral ischemia enhances glial expression of ecto-5'-nucleotidase. Brain Res 1997; 766: 213-226.
    • (1997) Brain Res , vol.766 , pp. 213-226
    • Braun, N.1    Lenz, C.2    Gillardon, F.3
  • 44
    • 25144490744 scopus 로고    scopus 로고
    • Adenosine receptor signaling in the brain immune system
    • Hasko G., Pachwer P., Vizi E.S. Adenosine receptor signaling in the brain immune system. Trends Pharmacol Sci 2005; 26: 511-516.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 511-516
    • Hasko, G.1    Pachwer, P.2    Vizi, E.S.3
  • 45
    • 0033198777 scopus 로고    scopus 로고
    • Activation of A1 adenosine or mGlu3 metabotropic glutamate receptors enhances he release of nerve growth factor and S-100b protein from cultured astrocytes
    • i wsp
    • Ciccarelli R., Di Iorio P., Bruno F. i wsp. Activation of A1 adenosine or mGlu3 metabotropic glutamate receptors enhances he release of nerve growth factor and S-100b protein from cultured astrocytes. Glia 1999; 27: 275-281.
    • (1999) Glia , vol.27 , pp. 275-281
    • Ciccarelli, R.1    di Iorio, P.2    Bruno, F.3
  • 46
    • 0030755898 scopus 로고    scopus 로고
    • Stimulation of interleukin- 6 secretion and gene transcription in primary astrocytes by adenosine
    • i wsp
    • Schwaninger M., Neher M., Viegas E. i wsp. Stimulation of interleukin- 6 secretion and gene transcription in primary astrocytes by adenosine. J Neurochem 1997; 69: 1145-1150.
    • (1997) J Neurochem , vol.69 , pp. 1145-1150
    • Schwaninger, M.1    Neher, M.2    Viegas, E.3
  • 47
    • 0035004684 scopus 로고    scopus 로고
    • Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis
    • i wsp
    • Johnston J.B., Silva C., Gonzalez G. i wsp. Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis. Ann Neurol 2001; 49: 650-658.
    • (2001) Ann Neurol , vol.49 , pp. 650-658
    • Johnston, J.B.1    Silva, C.2    Gonzalez, G.3
  • 48
    • 2542421699 scopus 로고    scopus 로고
    • Adenosine A3 receptor induced CCL2 synthesis in cultured mouse astrocytes
    • Wittendorp M.C., Boddeke H.W., Biber K. Adenosine A3 receptor induced CCL2 synthesis in cultured mouse astrocytes. Glia 2004; 46: 410-418.
    • (2004) Glia , vol.46 , pp. 410-418
    • Wittendorp, M.C.1    Boddeke, H.W.2    Biber, K.3
  • 49
    • 33947702519 scopus 로고    scopus 로고
    • Adenosine and lymphocyte regulation
    • i wsp
    • Gessi S., Varani K., Merighi S. i wsp. Adenosine and lymphocyte regulation. Purinergic Signal 2007; 3: 109-116.
    • (2007) Purinergic Signal , vol.3 , pp. 109-116
    • Gessi, S.1    Varani, K.2    Merighi, S.3
  • 50
    • 0030740773 scopus 로고    scopus 로고
    • Cell surface adenosine deaminase: Much more than an ectoenzyme
    • i wsp
    • Franco R., Casado V., Ciruela F. i wsp. Cell surface adenosine deaminase: much more than an ectoenzyme. Prog Neurobiol 1997; 52: 283-292.
    • (1997) Prog Neurobiol , vol.52 , pp. 283-292
    • Franco, R.1    Casado, V.2    Ciruela, F.3
  • 51
    • 21644464835 scopus 로고    scopus 로고
    • Adenosine deaminase and 5'-nucleotidase activities in peripheral blood T cell of multiple sclerosis patients
    • i wsp
    • Vivekanandhan S., Soundararajan C., Tripathi M. i wsp. Adenosine deaminase and 5'-nucleotidase activities in peripheral blood T cell of multiple sclerosis patients. Neurochem Res 2005; 30: 453-456.
    • (2005) Neurochem Res , vol.30 , pp. 453-456
    • Vivekanandhan, S.1    Soundararajan, C.2    Tripathi, M.3
  • 53
    • 33846436678 scopus 로고    scopus 로고
    • The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance
    • Robson S., Sevigny J., Zimmermann H. The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance. Purinergic Signal 2006; 2: 409-430.
    • (2006) Purinergic Signal , vol.2 , pp. 409-430
    • Robson, S.1    Sevigny, J.2    Zimmermann, H.3
  • 54
    • 34547098277 scopus 로고    scopus 로고
    • Expression of ectonucleotidase CD39 by Fox3+ Treg cells: Hydrolysis of extracellular ATP and immune suppression
    • i wsp
    • Borsellino G., Kleinewietfeld M., Di Mitri D. i wsp. Expression of ectonucleotidase CD39 by Fox3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007; 110: 1225-1232.
    • (2007) Blood , vol.110 , pp. 1225-1232
    • Borsellino, G.1    Kleinewietfeld, M.2    di Mitri, D.3
  • 55
    • 37749025228 scopus 로고    scopus 로고
    • CD39/NTPDase-1 activity and expression in normal leucocytes
    • i wsp
    • Pulte E., Broekman M., Olson K. i wsp. CD39/NTPDase-1 activity and expression in normal leucocytes. Thromb Res 2007; 121: 309-317.
    • (2007) Thromb Res , vol.121 , pp. 309-317
    • Pulte, E.1    Broekman, M.2    Olson, K.3
  • 56
    • 33947647317 scopus 로고    scopus 로고
    • CD39 and control of cellular immune responses
    • i wsp
    • Dwyer K., Deaglio S., Gao W. i wsp. CD39 and control of cellular immune responses. Purinergic Signal 2007; 3: 171-180.
    • (2007) Purinergic Signal , vol.3 , pp. 171-180
    • Dwyer, K.1    Deaglio, S.2    Gao, W.3
  • 57
    • 72649101947 scopus 로고    scopus 로고
    • The activity expression of NTPDase is altered in lymphocytes of multiple sclerosis patients
    • i wsp
    • Spanevello R., Mazzanti C., Schmatz R. i wsp. The activity expression of NTPDase is altered in lymphocytes of multiple sclerosis patients. Clin Chim Acta 2010; 411: 210-214.
    • (2010) Clin Chim Acta , vol.411 , pp. 210-214
    • Spanevello, R.1    Mazzanti, C.2    Schmatz, R.3
  • 58
    • 79958199894 scopus 로고    scopus 로고
    • Glutamate and ATP signalling in white matter pathology
    • Matute C. Glutamate and ATP signalling in white matter pathology. J Anat 2011; 219: 53-64.
    • (2011) J Anat , vol.219 , pp. 53-64
    • Matute, C.1
  • 59
    • 34548398189 scopus 로고    scopus 로고
    • P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis
    • Matute C., Torre I., Pérez-Cerdá F. P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. J Neurosci 2007; 27: 9525-9533.
    • (2007) J Neurosci , vol.27 , pp. 9525-9533
    • Matute, C.1    Torre, I.2    Pérez-Cerdá, F.3
  • 60
    • 79953220729 scopus 로고    scopus 로고
    • Neuroglial interactions mediated by purinergic signalling in the pathophysiology of CNS disorders
    • Matute C., Cavaliere F. Neuroglial interactions mediated by purinergic signalling in the pathophysiology of CNS disorders. Semin Cell Dev Biol 2011; 22: 252-259.
    • (2011) Semin Cell Dev Biol , vol.22 , pp. 252-259
    • Matute, C.1    Cavaliere, F.2
  • 61
    • 50249159536 scopus 로고    scopus 로고
    • P2X7 deficiency suppresses development of experimental autoimmune ence pha lo - myelitis
    • i wsp
    • Sharp A.J., Polak P.E., Simonini V. i wsp. P2X7 deficiency suppresses development of experimental autoimmune ence pha lo - myelitis. J Neuroinflammation 2008; 8: 33.
    • (2008) J Neuroinflammation , vol.8 , pp. 33
    • Sharp, A.J.1    Polak, P.E.2    Simonini, V.3
  • 62
    • 33644535464 scopus 로고    scopus 로고
    • Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: Evidence for loss of apoptotic activity in lymphocytes
    • Chen L., Brosnan C.F. Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes. J Immunol 2006; 176: 3115-3126.
    • (2006) J Immunol , vol.176 , pp. 3115-3126
    • Chen, L.1    Brosnan, C.F.2
  • 63
    • 77952870400 scopus 로고    scopus 로고
    • P2Y12 receptor protein in cortical gray matter lesions in multiple sclerosis
    • i wsp
    • Amadio S., Montilli C., Magliozzi R. i wsp. P2Y12 receptor protein in cortical gray matter lesions in multiple sclerosis. Cereb Cortex 2010; 20: 1263-1273.
    • (2010) Cereb Cortex , vol.20 , pp. 1263-1273
    • Amadio, S.1    Montilli, C.2    Magliozzi, R.3
  • 64
    • 0035004684 scopus 로고    scopus 로고
    • Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis
    • i wsp
    • Johnston J.B., Silva C., Gonzalez G. i wsp. Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis. Ann Neurol 2001; 49: 650-658.
    • (2001) Ann Neurol , vol.49 , pp. 650-658
    • Johnston, J.B.1    Silva, C.2    Gonzalez, G.3
  • 65
    • 0032587884 scopus 로고    scopus 로고
    • Dysregulation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients
    • i wsp
    • Mayne M., Shepel P.N., Jiang Y. i wsp. Dysregulation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients. Ann Neurol 1999; 45: 633-639.
    • (1999) Ann Neurol , vol.45 , pp. 633-639
    • Mayne, M.1    Shepel, P.N.2    Jiang, Y.3
  • 66
    • 77956323733 scopus 로고    scopus 로고
    • Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis
    • i wsp
    • Moreno B., Fernandez-Diez B., Di Penta A. i wsp. Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis. Mult Scler 2010; 16: 1102-1108.
    • (2010) Mult Scler , vol.16 , pp. 1102-1108
    • Moreno, B.1    Fernandez-Diez, B.2    di Penta, A.3
  • 67
    • 67349252457 scopus 로고    scopus 로고
    • Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients
    • i wsp
    • Amorini A.M., Petzold A., Tavazzi B. i wsp. Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients. Clin Biochem 2009; 42: 1001-1006.
    • (2009) Clin Biochem , vol.42 , pp. 1001-1006
    • Amorini, A.M.1    Petzold, A.2    Tavazzi, B.3
  • 68
    • 77952825583 scopus 로고    scopus 로고
    • Cerebrospinal fluid ATP metabolites in multiple sclerosis
    • i wsp
    • Lazzarino G., Amorini A.M., Eikelenboom M.J. i wsp. Cerebrospinal fluid ATP metabolites in multiple sclerosis. Mult Scler 2010; 16: 549-554.
    • (2010) Mult Scler , vol.16 , pp. 549-554
    • Lazzarino, G.1    Amorini, A.M.2    Eikelenboom, M.J.3
  • 69
    • 35748951914 scopus 로고    scopus 로고
    • Mechanism of action of IFN-β in the treatment of multiple sclerosis. A special reference to CD73 and adenosine
    • i wsp
    • Airas L., Niemela J., Yegutkin G. i wsp. Mechanism of action of IFN-β in the treatment of multiple sclerosis. A special reference to CD73 and adenosine. Ann NY Acad Sci 2007; 1110: 641-648.
    • (2007) Ann NY Acad Sci , vol.1110 , pp. 641-648
    • Airas, L.1    Niemela, J.2    Yegutkin, G.3
  • 70
    • 58149250587 scopus 로고    scopus 로고
    • IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier
    • i wsp
    • Niemala J., Ifergan I., Yegutin G. i wsp. IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur J Immunol 2008; 38: 2718-2726.
    • (2008) Eur J Immunol , vol.38 , pp. 2718-2726
    • Niemala, J.1    Ifergan, I.2    Yegutin, G.3
  • 71
    • 15044357461 scopus 로고    scopus 로고
    • Inflammation stimulates remyelination in areas of chronic demyelination
    • Foote A.K., Blakemore W.F. Inflammation stimulates remyelination in areas of chronic demyelination. Brain 2005; 128: 528-539.
    • (2005) Brain , vol.128 , pp. 528-539
    • Foote, A.K.1    Blakemore, W.F.2
  • 72
    • 10644228446 scopus 로고    scopus 로고
    • Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonist
    • i wsp
    • Merrman G.H., Ma I., Shum P. i wsp. Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonist. Bioorg Med Chem Lett 2005; 15: 435-438.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 435-438
    • Merrman, G.H.1    Ma, I.2    Shum, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.