Rapid and accurate assessment of seizure liability of drugs by using an optimal support vector machine method

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1848-1854

  Zhang, Hui ^a   Li, Wei ^a   Xie, Yang ^a   Wang, Wen Jing ^a   Li, Lin Li ^a   Yang, Sheng Yong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Drug induced seizures; Prediction model; Seizure; Support vector machine

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; 4 AMINOPYRIDINE; ACETYLSALICYLIC ACID; AMFEBUTAMONE; AMINOPHYLLINE; AMOXAPINE; BEMEGRIDE; BICUCULLINE METHIODIDE; CEFAZOLIN; CHLORPROMAZINE; DEXAMETHASONE; ENOXACIN; ISONIAZID; MAPROTILINE; NAPROXEN; PARACETAMOL; PENICILLIN G; PENTETRAZOLE; PERGOLIDE; PHYSOSTIGMINE; PICROTOXIN; PROTRIPTYLINE; RESERPINE; SCOPOLAMINE; SEMICARBAZIDE; STRYCHNINE; TOBRAMYCIN; VERAPAMIL;

ACCURACY; ALGORITHM; ARTICLE; BRAIN SLICE; CLASSIFICATION; COMPUTER MODEL; ELECTROENCEPHALOGRAM; HIPPOCAMPUS; IN VITRO STUDY; NONHUMAN; PREDICTION; SEIZURE; SUPPORT VECTOR MACHINE; VALIDATION PROCESS; ZEBRA FISH;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; LARVA; LOCOMOTION; MICE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; RATS; REPRODUCIBILITY OF RESULTS; SEIZURES; SUPPORT VECTOR MACHINES; ZEBRAFISH;

DANIO RERIO; RATTUS;

EID: 82655172584     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.05.015     Document Type: Article

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