Parkinsonism: Heterogeneity of a common neurological syndrome

Swiss Medical Weekly

Volumn 141, Issue NOVEMBER, 2011, Pages

  Bohlhalter, Stephan ^a   Kag̈i, Georg ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

Atypical parkinsonism; Oculomotor; Parkinson's disease; SWEDDS

Indexed keywords

ALPHA SYNUCLEIN; ANTIEMETIC AGENT; ANTIVERTIGO AGENT; CATECHOL METHYLTRANSFERASE INHIBITOR; DOPAMINE RECEPTOR STIMULATING AGENT; DOPAMINE TRANSPORTER; LEVODOPA; MONOAMINE OXIDASE B INHIBITOR; NEUROLEPTIC AGENT; TRACER;

BODY POSTURE; BRADYKINESIA; BRAIN DEPTH STIMULATION; CLINICAL EXAMINATION; CLINICAL FEATURE; CORTICOBASAL DEGENERATION; CORTICOBASAL SYNDROME; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; DIFFUSE LEWY BODY DISEASE; DISEASE CLASSIFICATION; DYSTONIA; EYE MOVEMENT DISORDER; HUMAN; MUSCLE RIGIDITY; NEUROIMAGING; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PARKINSONISM; PATHOLOGICAL REFLEX; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; POSTURAL REFLEX; PROGNOSIS; PROGRESSIVE SUPRANUCLEAR PALSY; REVIEW; SHY DRAGER SYNDROME; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT OUTCOME; TREMOR; CLASSIFICATION; PATHOLOGY;

DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC IMAGING; HUMANS; PARKINSONIAN DISORDERS;

EID: 82655169414     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: 10.4414/smw.2011.13293     Document Type: Review

References (73)

1. Graybiel AM. The basal ganglia. Curr Biol. 2000;10(14):R509-11. (Pubitemid 30597190)
2. Redgrave P, Rodriguez M, Smith Y, Rodriguez-Oroz MC, Lehericy S, Bergman H, et al. Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease. Nat Rev Neurosci. 2010;11(11):760-72.
3. Hallett M. Parkinson revisited: pathophysiology of motor signs. Adv Neurol. 2003;91:19-28.
4. Benninger DH, Thees S, Kollias SS, Bassetti CL, Waldvogel D. Morphological differences in Parkinson's disease with and without rest tremor. J Neurol. 2009;256(2):256-63.
5. Hallett M. The intrinsic and extrinsic aspects of freezing of gait. Mov Disord. 2008;23(Suppl 2):S439-43.
6. Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev Mol Med. 2009;11:e22.
7. Wider C, Ross OA, Wszolek ZK. Genetics of Parkinson disease and essential tremor. Curr Opin Neurol. 2010;23(4):388-93.
8. Hardy J. Genetic analysis of pathways to Parkinson disease. Neuron. 2010;68 (2):201-6.
9. Esper CD, Factor SA. Failure of recognition of drug-induced parkinsonism in the elderly. Mov Disord. 2008;23(3):401-4.
10. Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ. What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. Neurology. 1992;42(6):1142-6.
11. Quinn N. Parkinsonism - recognition and differential diagnosis. BMJ. 1995;310(6977):447-52.
12. Jankovic J, Watts RL, Martin W, Boroojerdi B. Transdermal rotigotine: double-blind, placebo-controlled trial in Parkinson disease. Arch Neurol. 2007;64(5):676-82. (Pubitemid 46789833)
13. Shih LC, Tarsy D. Deep brain stimulation for the treatment of atypical parkinsonism. Mov Disord. 2007;22(15):2149-55.
14. Ben-Shlomo Y, Wenning GK, Tison F, Quinn NP. Survival of patients with pathologically proven multiple system atrophy: a meta-analysis. Neurology. 1997;48(2):384-93. (Pubitemid 27087609)
15. Jellinger KA, Wenning GK, Seppi K. Predictors of survival in dementia with lewy bodies and Parkinson dementia. Neurodegener Dis. 2007;4(6):428-30. (Pubitemid 47557284)
16. Nath U, Ben-Shlomo Y, Thomson RG, Lees AJ, Burn DJ. Clinical features and natural history of progressive supranuclear palsy: a clinical cohort study. Neurology. 2003;60(6):910-6. (Pubitemid 36348920)
17. Wenning GK, Litvan I, Jankovic J, Granata R, Mangone CA, McKee A, et al. Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination. J Neurol Neurosurg Psychiatry. 1998;64(2):184-9. (Pubitemid 28159799)
18. Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology. 1996;47(1):1-9. (Pubitemid 26243849)
19. Williams DR, de Silva R, Paviour DC, Pittman A, Watt HC, Kilford L, et al. Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism. Brain. 2005;128(Pt 6):1247-58. (Pubitemid 40826179)
20. Rebeiz JJ, Kolodny EH, Richardson EP, Jr. Corticodentatonigral degeneration with neuronal achromasia. Arch Neurol. 1968;18(1):20-33.
21. Gebhardt A, Vanbellingen T, Baronti F, Kersten B, Bohlhalter S. Poor dopaminergic response of impaired dexterity in Parkinson's disease: Bradykinesia or limb kinetic apraxia? Mov Disord. 2008;23(12):1701-6.
22. Leiguarda RC, Merello M, Nouzeilles MI, Balej J, Rivero A, Nogues M. Limb-kinetic apraxia in corticobasal degeneration: clinical and kinematic features. Mov Disord. 2003;18(1):49-59. (Pubitemid 36150207)
23. Vanbellingen T, Kersten B, Bellion M, Temperli P, Baronti F, Muri R, et al. Impaired finger dexterity in Parkinson's disease is associated with praxis function. Brain and Cognition 2011; in press.
24. Wenning GK, Colosimo C, Geser F, Poewe W. Multiple system atrophy. Lancet Neurol. 2004;3(2):93-103. (Pubitemid 38121312)
25. Kollensperger M, Geser F, Seppi K, Stampfer-Kountchev M, Sawires M, Scherfler C, et al. Red flags for multiple system atrophy. Mov Disord. 2008;23(8):1093-9.
26. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863-72. (Pubitemid 43970103)
27. Gaig C, Valldeoriola F, Gelpi E, Ezquerra M, Llufriu S, Buongiorno M, et al. Rapidly progressive diffuse Lewy body disease. Mov Disord. 2011;26(7):1316-23.
28. Abdo WF, Borm GF, Munneke M, Verbeek MM, Esselink RA, Bloem BR. Ten steps to identify atypical parkinsonism. J Neurol Neurosurg Psychiatry. 2006;77(12):1367-9. (Pubitemid 44851998)
29. Aerts MB, Abdo WF, Bloem BR. The "bicycle sign" for atypical parkinsonism. Lancet. 2011;377(9760):125-6.
30. Vidailhet M, Rivaud S, Gouider-Khouja N, Pillon B, Bonnet AM, Gaymard B, et al. Eye movements in parkinsonian syndromes. Ann Neurol. 1994;35(4):420-6.
31. Brett FM, Henson C, Staunton H. Familial diffuse Lewy body disease, eye movement abnormalities, and distribution of pathology. Arch Neurol. 2002;59(3):464-7. (Pubitemid 34208158)
32. Quinn N. The "round the houses" sign in progressive supranuclear palsy. Ann Neurol. 1996;40(6):951. (Pubitemid 27044622)
33. Rivaud-Pechoux S, Vidailhet M, Gallouedec G, Litvan I, Gaymard B, Pierrot-Deseilligny C. Longitudinal ocular motor study in cortico-basal degeneration and progressive supranuclear palsy. Neurology. 2000;54(5):1029-32. (Pubitemid 30151841)
34. Leigh RJ, Kennard C. Using saccades as a research tool in the clinical neurosciences. Brain. 2004;127(Pt 3):460-77. (Pubitemid 38295465)
35. Pinkhardt EH, Jurgens R, Becker W, Valdarno F, Ludolph AC, Kassubek J. Differential diagnostic value of eye movement recording in PSP-parkinsonism, Richardson's syndrome, and idiopathic Parkinson's disease. J Neurol. 2008;255(12):1916-25.
36. Mosimann UP, Muri RM, Burn DJ, Felblinger J, O'Brien JT, McKeith IG. Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies. Brain. 2005;128(Pt 6):1267-76. (Pubitemid 40826181)
37. Abadi RV, Gowen E. Characteristics of saccadic intrusions. Vision Res. 2004;44(23):2675-90. (Pubitemid 39092497)
38. Anderson T, Luxon L, Quinn N, Daniel S, Marsden CD, Bronstein A. Oculomotor function in multiple system atrophy: clinical and laboratory features in 30 patients. Mov Disord. 2008;23(7):977-84.
39. Rascol O, Sabatini U, Simonetta-Moreau M, Montastruc JL, Rascol A, Clanet M. Square wave jerks in parkinsonian syndromes. J Neurol Neurosurg Psychiatry. 1991;54(7):599-602.
40. Kuniyoshi S, Riley DE, Zee DS, Reich SG, Whitney C, Leigh RJ. Distinguishing progressive supranuclear palsy from other forms of Par- kinson's disease: evaluation of new signs. Ann N Y Acad Sci. 2002;956:484-6. (Pubitemid 34457650)
41. Hely MA, Morris JG, Reid WG, Trafficante R. Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord. 2005;20(2):190-9. (Pubitemid 40361122)
42. Zadikoff C, Lang AE, Klein C. The "essentials" of essential palatal tremor: a reappraisal of the nosology. Brain. 2006;129(Pt 4):832-40.
43. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA. 2002;287(13):1653-61.
44. Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, et al. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004;351(24):2498-508.
45. Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C, et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann Neurol. 2003;54(1):93-101. (Pubitemid 36764985)
46. Kagi G, Bhatia KP, Tolosa E. The role of DAT-SPECT in movement disorders. J Neurol Neurosurg Psychiatry. 2010;81(1):5-12.
47. Schwingenschuh P, Ruge D, Edwards MJ, Terranova C, Katschnig P, Carrillo F, et al. Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: a clinical and electrophysiological study. Mov Disord. 2010;25(5):560-9.
48. Silveira-Moriyama L, Schwingenschuh P, O'Donnell A, Schneider SA, Mir P, Carrillo F, et al. Olfaction in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs). J Neurol Neurosurg Psychiatry. 2009;80(7):744-8.
49. Alves G, Larsen JP, Emre M, Wentzel-Larsen T, Aarsland D. Changes in motor subtype and risk for incident dementia in Parkinson's disease. Mov Disord. 2006;21(8):1123-30. (Pubitemid 44336596)
50. Lewis SJ, Foltynie T, Blackwell AD, Robbins TW, Owen AM, Barker RA. Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach. J Neurol Neurosurg Psychiatry. 2005;76(3):343-8. (Pubitemid 40299121)
51. Selikhova M, Williams DR, Kempster PA, Holton JL, Revesz T, Lees AJ. A clinico-pathological study of subtypes in Parkinson's disease. Brain. 2009;132(Pt 11):2947-57.
52. Josephs KA, Matsumoto JY, Ahlskog JE. Benign tremulous parkinsonism. Arch Neurol. 2006;63(3):354-7.
53. van Rooden SM, Colas F, Martinez-Martin P, Visser M, Verbaan D, Marinus J, et al. Clinical subtypes of Parkinson's disease. Mov Disord. 2011;26(1):51-8.
54. Williams DR, Lees AJ. Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol. 2009;8(3):270-9.
55. Williams DR, Holton JL, Strand K, Revesz T, Lees AJ. Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy. Mov Disord. 2007;22(15):2235-41.
56. Josephs KA, Boeve BF, Duffy JR, Smith GE, Knopman DS, Parisi JE, et al. Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia. Neurocase. 2005;11(4):283-96. (Pubitemid 41179599)
57. Boeve BF, Lang AE, Litvan I. Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia. Ann Neurol. 2003;54(Suppl 5):S15-9. (Pubitemid 36760148)
58. Josephs KA, Petersen RC, Knopman DS, Boeve BF, Whitwell JL, Duffy JR, et al. Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology. 2006;66(1):41-8. (Pubitemid 43739589)
59. Ling H, O'Sullivan SS, Holton JL, Revesz T, Massey LA, Williams DR, et al. Does corticobasal degeneration exist? A clinicopathological re-evaluation. Brain. 2010;133(Pt 7):2045-57.
60. Kertesz A, McMonagle P, Blair M, Davidson W, Munoz DG. The evolution and pathology of frontotemporal dementia. Brain. 2005;128(Pt 9):1996-2005. (Pubitemid 41253267)
61. Tang CC, Poston KL, Eckert T, Feigin A, Frucht S, Gudesblatt M, et al. Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis. Lancet Neurol. 2010;9(2):149-58.
62. Schrag A, Good CD, Miszkiel K, Morris HR, Mathias CJ, Lees AJ, et al. Differentiation of atypical parkinsonian syndromes with routine MRI. Neurology. 2000;54(3):697-702. (Pubitemid 30082941)
63. Drayer B, Burger P, Darwin R, Riederer S, Herfkens R, Johnson GA. MRI of brain iron. AJR Am J Roentgenol. 1986;147(1):103-10. (Pubitemid 16066336)
64. Paviour DC, Price SL, Jahanshahi M, Lees AJ, Fox NC. Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations. Mov Disord. 2006;21(7):989-96. (Pubitemid 44184601)
65. Quattrone A, Nicoletti G, Messina D, Fera F, Condino F, Pugliese P, et al. MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology. 2008;246(1):214-21. (Pubitemid 350305046)
66. Longoni G, Agosta F, Kostic VS, Stojkovic T, Pagani E, Stosic-Opincal T, et al. MRI measurements of brainstem structures in patients with Richardson's syndrome, progressive supranuclear palsy-parkinsonism, and Parkinson's disease. Mov Disord. 2011;26(2):247-55.
67. Schofield EC, Hodges JR, Macdonald V, Cordato NJ, Kril JJ, Halliday GM. Cortical atrophy differentiates Richardson's syndrome from the parkinsonian form of progressive supranuclear palsy. Mov Disord. 26(2):256-63.
68. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron. 2009;62(1):42-52.
69. Wenning GK, Krismer F, Poewe W. New insights into atypical parkinsonism. Curr Opin Neurol. 2011.
70. Dickson DW, Ahmed Z, Algom AA, Tsuboi Y, Josephs KA. Neuropathology of variants of progressive supranuclear palsy. Curr Opin Neurol. 2010;23(4):394-400.
71. Ebersbach G, Ebersbach A, Edler D, Kaufhold O, Kusch M, Kupsch A, et al. Comparing exercise in Parkinson's disease - the Berlin LSVT(R)BIG study. Mov Disord. 2010;25(12):1902-8.
72. Zampieri C, Di Fabio RP. Improvement of gaze control after balance and eye movement training in patients with progressive supranuclear palsy: a quasi-randomized controlled trial. Arch Phys Med Rehabil. 2009;90(2):263-70.
73. Gnädinger M, Mellinghoff HU, Kaelin-Lang A. Swiss Med Wkly. 2011 Feb 16;141:w13154. doi: 10.4414/smw.2011.13154.