Pure akinesia with gait freezing: A third clinical phenotype of progressive supranuclear palsy

Movement Disorders

Volumn 22, Issue 15, 2007, Pages 2235-2241

  Williams, David R ^a,b,c,d   Holton, Janice L ^b,c,d   Strand, Kate ^c,d   Revesz, Tamas ^c,d   Lees, Andrew J ^b,c,d  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Queen Square Brain Bank for Neurological Disorders ^*  (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Gait ignition failure; Primary progressive freezing gait; Progressive supranuclear palsy (PSP); Pure akinesia with gait freezing

Indexed keywords

AMANTADINE; CARBIDOPA PLUS LEVODOPA; CHOLINERGIC RECEPTOR BLOCKING AGENT; LEVODOPA;

ADULT; AGED; AKINESIA; ALZHEIMER DISEASE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEMENTIA; DISEASE COURSE; FEMALE; GAIT DISORDER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; OPHTHALMOPLEGIA; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; RIGIDITY; SPEECH; TREATMENT FAILURE; TREMOR;

ADULT; AGED; ALPHA-SYNUCLEIN; BRAIN; FATAL OUTCOME; FEMALE; GAIT DISORDERS, NEUROLOGIC; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; MALE; MIDDLE AGED; MOVEMENT DISORDERS; PHENOTYPE; RETROSPECTIVE STUDIES; SUPRANUCLEAR PALSY, PROGRESSIVE;

EID: 38049130310     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.21698     Document Type: Article

References (54)

1. Imai H, Narabayashi H. Akinesia - concerning 2 cases of pure akinesia. Adv Neurol Sci (Tokyo) 1974;18:787-794.
2. Mizusawa H, Mochizuki A, Ohkoshi N, Yoshizawa K, Kanazawa I, Imai H. Progressive supranuclear palsy presenting with pure akinesia. Adv Neurol 1993;60:618-621.
3. Barbeau A, Siegfried J. Contribution of levodopa therapy to the neuropharmacology of akinesia. In: Parkinson's disease. Bern: Hans Huber; 1972. p 151-174.
4. Petren K. Ueber den Zusammenhang zwischen anatomisch bedingter und functioneller Gangstfrung (besonders in der Form von trepidanter Abasie) im Greisenalter. Arch Psychiatr Nervenkr 1901;34:444-489.
5. Baezner H, Hennerici M. From trepidant abasia to motor network failure-gait disorders as a consequence of subcortical vascular encephalopathy (SVE): review of historical and contemporary concepts. J Neurol Sci 2005;229-230:81-88.
6. Atchison PR, Thompson PD, Frackowiak RS, Marsden CD. The syndrome of gait ignition failure: a report of six cases. Mov Disord 1993;8:285-292.
7. Achiron A, Ziv I, Goren M, et al. Primary progressive freezing gait. Mov Disord 1993;8:293-297.
8. Quinn NP, Luthert P, Honavar M, Marsden CD. Pure akinesia due to lewy body Parkinson's disease: a case with pathology. Mov Disord 1989;4:85-89.
9. Imai H, Narabayashi H. A case of pure akinesia due to Lewy body parkinson's disease with pathology. Mov Disord 1990;5:90-91.
10. Brissaud E. Lecons sur les maladies nerveuses. Paris: Masson; 1895.
11. Imai H, Nakamura T, Kondo T, Narabayashi H. Dopa-unresponsive pure akinesia or freezing. A condition within a wide spectrum of PSP? Adv Neurol 1993;60:622-625.
12. Factor SA, Jennings DL, Molho ES, Marek KL. The natural history of the syndrome of primary progressive freezing gait. Arch Neurol 2002;59:1778-1783.
13. Factor SA, Higgins DS, Qian J. Primary progressive freezing gait: a syndrome with many causes. Neurology 2006;66:411-414.
14. Riley DE, Fogt N, Leigh RJ. The syndrome of 'pure akinesia' and its relationship to progressive supranuclear palsy. Neurology 1994;44:1025-1029.
15. Konishi Y, Shirabe T, Katayama S, Funakawa I, Terao A. Autopsy case of pure akinesia showing pallidonigro-luysian atrophy. Neuropathology 2005;25:220-227.
16. Yoshikawa H, Oda Y, Sakajiri K, et al. Pure akinesia manifested neuroleptic malignant syndrome: a clinical variant of progressive supranuclear palsy. Acta Neuropathol (Berl) 1997;93:306-309.
17. Homma Y, Takahashi H, Takeda S, Ikuta F. [An autopsy case of progressive supranuclear palsy showing "pure akinesia without rigidity and tremor and with no effect by L-dopa therapy (Imai)"]. No To Shinkei 1987;39:183-187.
18. Matsuo H, Takashima H, Kishikawa M, et al. Pure akinesia: an atypical manifestation of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 1991;54:397-400.
19. Williams DR, de Silva R, Paviour DC, et al. Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism. Brain 2005;128:1247-1258.
20. Williams DR, Holton J, Strand C, et al. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain 2007;130:1566-1576.
21. Tsuboi Y, Josephs KA, Boeve BF, et al. Increased tau burden in the cortices of progressive supranuclear palsy presenting with cortico-basal syndrome. Mov Disord 2005;20:982-988.
22. Kosaka K. Diffuse Lewy body disease in Japan. J Neurol 1990;237:197-204.
23. Lantos PL. Diagnostic criteria for corticobasal degeneration. J Neurol Neurosurg Psychiatry 2000;69:705-706.
24. Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999;163:94-98.
25. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479-486.
26. McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996;47:1113-1124.
27. Litvan I, Hauw JJ, Bartko JJ, et al. Validity and reliability of the preliminary NINDS neuropathologic criteria for progressive supranuclear palsy and related disorders. J Neuropathol Exp Neurol 1996;55:97-105.
28. Litvan I, Agid Y, Calne D, et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 1996;47:1-9.
29. Daniel SE, de BV, Lees AJ. The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy): a reappraisal. Brain 1995;118:759-770.
30. Morris HR, Gibb G, Katzenschlager R, et al. Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy. Brain 2002;125:969-975.
31. Hughes AJ, Daniel SE, Ben-Shlomo Y, Lees AJ. The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 2002;125:861-870.
32. Fitz Gerald PM, Jankovic J. Lower body parkinsonism: evidence for vascular etiology. Mov Disord 1989;4:249-260.
33. Yamamoto M, Ujike H, Ogawa N. Effective treatment of pure akinesia with L-threo-3,4-dihydroxyphenylserine (DOPS): report of a case, with pharmacological considerations. Clin Neuropharmacol 1985;8:334-342.
34. Foltynie T, Barker R, Brayne C. Vascular parkinsonism: a review of the precision and frequency of the diagnosis. Neuroepidemiology 2002;21:1-7.
35. Jellinger KA. Vascular parkinsonism - neuropathologies findings. Acta Neurol Scand 2002;105:414-415.
36. Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ. What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. Neurology 1992;42:1142-1146.
37. Jellinger KA. The pathology of Parkinson's disease. Adv Neurol 2001;86:55-72.
38. Zijlmans JC, Daniel SE, Hughes AJ, Revesz T, Lees AJ. Clinico-pathological investigation of vascular parkinsonism, including clinical criteria for diagnosis. Mov Disord 2004;19:630-640.
39. Maraganore DM, Anderson DW, Bower JH, McDonnell SK, Rocca WA. Autopsy patterns for Parkinson's disease and related disorders in Olmsted County, Minnesota Neurology 1999;53:1342-1344.
40. Kim JS, Lee KJ, Guak TH, Kim BS, Yang DW. Gait ignition failure after unilateral anteromedial pallidotomy. Eur Neurol 2001;46:56-57.
41. Taniwaki T, Hosokawa S, Goto I, et al. Positron emission tomography (PET) in "pure akinesia". J Neurol Sci 1992;107:34-39.
42. Imai H. Clinicophysiological features of akinesia. Eur Neurol 1996;36 (Suppl 1):9-12.
43. Kondo S, Tanaka M, Sun X, Okamoto K, Hirai S. [Cerebral blood flow and oxygen metabolism in patients with pure akinesia and progressive supranuclear palsy]. Rinsho Shinkeigaku 1994;34:531-537.
44. Ohno T, Murata M, Ishii K, Nagura H, Yamanouchi H. [Two cases of pure akinesia with unusual activation in dorsal part of the frontal lobe during gait-surface EMG and PET study]. Rinsho Shinkeigaku 1997;37:675-679.
45. Yener GG, Kaya GC, Ozturk V, Akdal G. Improvement in Tc-99m HMPAO brain SPECT findings during donepezil therapy in a patient with pure akinesia. Ann Nucl Med 2005;19:607-609.
46. Mizusawa H. ["Pure akinesia" and progressive supranuclear palsy]. No To Shinkei 1993;45:113-118.
47. Yoritaka A, Hattori T, Hattori Y, et al. [A 85-year-old woman with the onset of progressive gait disturbance at 80 years of the age]. No To Shinkei 1997;49:379-389.
48. Katayama S, Watanabe C, Khoriyama T, et al. Slowly progressive L-dopa nonresponsive pure akinesia due to nigropallidal degeneration: a clinicopathological case study. J Neurol Sci 1998;161:69-172.
49. Pramstaller PP, Salerno A, Bhatia KP, Prugger M, Marsden CD. Primary central nervous system lymphoma presenting with a parkinsonian syndrome of pure akinesia. J Neurol 1999;246:934-938.
50. Suzuki T, Yamamoto M, Saitoh M, Aoki A, Imai H, Narabayashi H. [A case of intracranial malignant lymphoma with pure akinesia and repeated regression on CT scans]. No To Shinkei 1984;36:689-696.
51. Mori H, Motoi Y, Kobayashi T, et al. Tau accumulation in a patient with pallidonigroluysian atrophy. Neurosci Lett 2001;309:89-92.
52. Imai H, Narabayashi H, Sakata E. "Pure akinesia" and the later added supranuclear ophthalmoplegia. Adv Neurol 1987;45:207-212.
53. Nakagawa T, Uyama E, Kumamoto T, Uchino M, Araki S. [A case of pure akinesia with pheochromocytoma]. Rinsho Shinkeigaku 1987;27:1150-1153.
54. Molinuevo JL, Marti MJ, Blesa R, Tolosa E. Pure akinesia: an unusual phenotype of Hallervorden-Spatz syndrome. Mov Disord 2003;18:1351-1353.