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Volumn 55, Issue 7-9, 2011, Pages 731-744

c-Jun N-terminal kinase activity supports multiple phases of 3D-mammary epithelial acinus formation

Author keywords

Acinus; EMT; ERK; JNK; Mammary epithelial cell; MAP kinase

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; FOCAL ADHESION KINASE; INTEGRIN; LAMININ; MITOGEN ACTIVATED PROTEIN KINASE; PAXILLIN; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

EID: 82555201377     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.113374sm     Document Type: Article
Times cited : (8)

References (42)
  • 1
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • ADAM, L., VADLAMUDI, R., KONDAPAKA, S.B., CHERNOFF, J., MENDELSOHN, J. and KUMAR, R. (1998). Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem 273: 28238-28246.
    • (1998) J Biol Chem , vol.273 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 2
    • 0034697303 scopus 로고    scopus 로고
    • Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
    • ADAM, L., VADLAMUDI, R., MANDAL, M., CHERNOFF, J. and KUMAR, R. (2000). Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 275: 12041-12050.
    • (2000) J Biol Chem , vol.275 , pp. 12041-12050
    • Adam, L.1    Vadlamudi, R.2    Mandal, M.3    Chernoff, J.4    Kumar, R.5
  • 3
    • 28444438456 scopus 로고    scopus 로고
    • Expression of BRCA1, HER-1 (EGFR) and HER-2 in sporadic breast cancer and relationships to other clinicopathological prognostic features
    • ANSQUER, Y., MANDELBROT, L., LEHY, T., SALOMON, L., DHAINAUT, C., MADELENAT, P., FELDMANN, G. and WALKER, F. (2005). Expression of BRCA1, HER-1 (EGFR) and HER-2 in sporadic breast cancer and relationships to other clinicopathological prognostic features. Anticancer Res 25: 4535-4541.
    • (2005) Anticancer Res , vol.25 , pp. 4535-4541
    • Ansquer, Y.1    Mandelbrot, L.2    Lehy, T.3    Salomon, L.4    Dhainaut, C.5    Madelenat, P.6    Feldmann, G.7    Walker, F.8
  • 4
    • 0346462998 scopus 로고    scopus 로고
    • p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
    • BALASENTHIL, S., SAHIN, A.A., BARNES, C.J., WANG, R.A., PESTELL, R.G., VADLAMUDI, R.K. and KUMAR, R. (2004). p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. J Biol Chem 279: 1422-1428.
    • (2004) J Biol Chem , vol.279 , pp. 1422-1428
    • Balasenthil, S.1    Sahin, A.A.2    Barnes, C.J.3    Wang, R.A.4    Pestell, R.G.5    Vadlamudi, R.K.6    Kumar, R.7
  • 6
    • 0033970533 scopus 로고    scopus 로고
    • Dual specificity phosphatases: A gene family for control of MAP kinase function
    • CAMPS, M., NICHOLS, A. and ARKINSTALL, S. (2000). Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J 14: 6-16.
    • (2000) FASEB J , vol.14 , pp. 6-16
    • Camps, M.1    Nichols, A.2    Arkinstall, S.3
  • 7
    • 25444443688 scopus 로고    scopus 로고
    • Modelling glandular epithelial cancers in three-dimensional cultures
    • DEBNATH, J. and BRUGGE, J.S. (2005). Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5: 675-688.
    • (2005) Nat Rev Cancer , vol.5 , pp. 675-688
    • Debnath, J.1    Brugge, J.S.2
  • 8
    • 0037020196 scopus 로고    scopus 로고
    • The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
    • DEBNATH, J., MILLS, K.R., COLLINS, N.L., REGINATO, M.J., MUTHUSWAMY, S.K. and BRUGGE, J.S. (2002). The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111: 29-40.
    • (2002) Cell , vol.111 , pp. 29-40
    • Debnath, J.1    Mills, K.R.2    Collins, N.L.3    Reginato, M.J.4    Muthuswamy, S.K.5    Brugge, J.S.6
  • 9
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • DEBNATH, J., MUTHUSWAMY, S.K. and BRUGGE, J.S. (2003a). Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30: 256-268.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 10
    • 0242266916 scopus 로고    scopus 로고
    • Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
    • DEBNATH, J., WALKER, S.J. and BRUGGE, J.S. (2003b). Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol 163: 315-326.
    • (2003) J Cell Biol , vol.163 , pp. 315-326
    • Debnath, J.1    Walker, S.J.2    Brugge, J.S.3
  • 11
    • 0025320158 scopus 로고
    • EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling
    • DI FIORE, P.P., SEGATTO, O., TAYLOR, W.G., AARONSON, S.A. and PIERCE, J.H. (1990). EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling. Science 248: 79-83.
    • (1990) Science , vol.248 , pp. 79-83
    • di Fiore, P.P.1    Segatto, O.2    Taylor, W.G.3    Aaronson, S.A.4    Pierce, J.H.5
  • 12
    • 34249325876 scopus 로고    scopus 로고
    • Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: C-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior
    • DIMRI, M., NARAMURA, M., DUAN, L., CHEN, J., ORTEGA-CAVA, C., CHEN, G., GOSWAMI, R., FERNANDES, N., GAO, Q., DIMRI, G.P. et al., (2007). Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior. Cancer Res 67: 4164-4172.
    • (2007) Cancer Res , vol.67 , pp. 4164-4172
    • Dimri, M.1    Naramura, M.2    Duan, L.3    Chen, J.4    Ortega-Cava, C.5    Chen, G.6    Goswami, R.7    Fernandes, N.8    Gao, Q.9    Dimri, G.P.10
  • 13
    • 2042538029 scopus 로고    scopus 로고
    • Structure and regulation of MAPK phosphatases
    • FAROOQ, A. and ZHOU, M.M. (2004). Structure and regulation of MAPK phosphatases. Cell Signal 16: 769-779.
    • (2004) Cell Signal , vol.16 , pp. 769-779
    • Farooq, A.1    Zhou, M.M.2
  • 14
    • 0029912847 scopus 로고    scopus 로고
    • Expression of a 74-kDa nuclear factor 1 (NF1) protein is induced in mouse mammary gland involution. Involution-enhanced occupation of a twin NF1 binding element in the testosterone-repressed prostate message-2/clusterin promoter
    • FURLONG, E.E., KEON, N.K., THORNTON, F.D., REIN, T. and MARTIN, F. (1996). Expression of a 74-kDa nuclear factor 1 (NF1) protein is induced in mouse mammary gland involution. Involution-enhanced occupation of a twin NF1 binding element in the testosterone-repressed prostate message-2/clusterin promoter. J Biol Chem 271: 29688-29697.
    • (1996) J Biol Chem , vol.271 , pp. 29688-29697
    • Furlong, E.E.1    Keon, N.K.2    Thornton, F.D.3    Rein, T.4    Martin, F.5
  • 15
    • 4143135282 scopus 로고    scopus 로고
    • Apoptosis regulation in the mammary gland
    • GREEN, K.A. and STREULI, C.H. (2004). Apoptosis regulation in the mammary gland. Cell Mol Life Sci 61: 1867-1883.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 1867-1883
    • Green, K.A.1    Streuli, C.H.2
  • 17
    • 0036676174 scopus 로고    scopus 로고
    • Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway
    • JANDA, E., LITOS, G., GRUNERT, S., DOWNWARD, J. and BEUG, H. (2002). Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway. Oncogene 21: 5148-5159.
    • (2002) Oncogene , vol.21 , pp. 5148-5159
    • Janda, E.1    Litos, G.2    Grunert, S.3    Downward, J.4    Beug, H.5
  • 18
    • 67650588401 scopus 로고    scopus 로고
    • Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction
    • JECHLINGER, M., PODSYPANINA, K, VARMUS H. (2009). Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes Dev 23: 1677-1688.
    • (2009) Genes Dev , vol.23 , pp. 1677-1688
    • Jechlinger, M.1    Podsypanina, K.2    Varmus, H.3
  • 19
    • 4744365623 scopus 로고    scopus 로고
    • Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal
    • KARLSSON, M., MATHERS, J., DICKINSON, R.J., MANDL, M. and KEYSE, S.M. (2004). Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal. J Biol Chem 279: 41882-41891.
    • (2004) J Biol Chem , vol.279 , pp. 41882-41891
    • Karlsson, M.1    Mathers, J.2    Dickinson, R.J.3    Mandl, M.4    Keyse, S.M.5
  • 20
    • 0031459917 scopus 로고    scopus 로고
    • Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
    • KEELY, P.J., WESTWICK, J.K., WHITEHEAD, I.P., DER, C.J. and PARISE, L.V. (1997). Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390: 632-636.
    • (1997) Nature , vol.390 , pp. 632-636
    • Keely, P.J.1    Westwick, J.K.2    Whitehead, I.P.3    Der, C.J.4    Parise, L.V.5
  • 21
    • 0034096201 scopus 로고    scopus 로고
    • Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
    • KEYSE, S.M. (2000). Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol 12: 186-192.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 186-192
    • Keyse, S.M.1
  • 22
    • 41649085584 scopus 로고    scopus 로고
    • p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
    • LI, Q., MULLINS, S.R., SLOANE, B.F. and MATTINGLY, R.R. (2008). p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia 10: 314-329.
    • (2008) Neoplasia , vol.10 , pp. 314-329
    • Li, Q.1    Mullins, S.R.2    Sloane, B.F.3    Mattingly, R.R.4
  • 24
    • 41449106480 scopus 로고    scopus 로고
    • JNK signaling controls border cell cluster integrity and collective cell migration
    • LLENSE, F. and MARTIN-BLANCO, E. (2008). JNK signaling controls border cell cluster integrity and collective cell migration. Curr Biol 18: 538-544.
    • (2008) Curr Biol , vol.18 , pp. 538-544
    • Llense, F.1    Martin-Blanco, E.2
  • 25
    • 0036441336 scopus 로고    scopus 로고
    • Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
    • MARSHMAN, E. and STREULI, C.H. (2002). Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function. Breast Cancer Res 4: 231-239.
    • (2002) Breast Cancer Res , vol.4 , pp. 231-239
    • Marshman, E.1    Streuli, C.H.2
  • 26
    • 3142743861 scopus 로고    scopus 로고
    • Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling
    • MURTAGH, J., MCARDLE, E., GILLIGAN, E., THORNTON, L., FURLONG, F. and MARTIN, F. (2004). Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling. J Cell Biol 166: 133-143.
    • (2004) J Cell Biol , vol.166 , pp. 133-143
    • Murtagh, J.1    McArdle, E.2    Gilligan, E.3    Thornton, L.4    Furlong, F.5    Martin, F.6
  • 27
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • MUTHUSWAMY, S.K., LI, D., LELIEVRE, S., BISSELL, M.J. and BRUGGE, J.S. (2001). ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 3: 785-792.
    • (2001) Nat Cell Biol , vol.3 , pp. 785-792
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 28
    • 0034873386 scopus 로고    scopus 로고
    • The role of overexpressed HER2 in transformation
    • NEVE, R.M., LANE, H.A. and HYNES, N.E. (2001). The role of overexpressed HER2 in transformation. Ann Oncol 12 Suppl 1: S9-S13.
    • (2001) Ann Oncol , vol.12 , Issue.SUPPL. 1
    • Neve, R.M.1    Lane, H.A.2    Hynes, N.E.3
  • 29
    • 0036636095 scopus 로고    scopus 로고
    • Opinion: Building epithelial architecture: Insights from three-dimensional culture models
    • O'BRIEN, L.E., ZEGERS, M.M. and MOSTOV, K.E. (2002). Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol 3: 531-537.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 531-537
    • O'brien, L.E.1    Zegers, M.M.2    Mostov, K.E.3
  • 30
    • 0037102190 scopus 로고    scopus 로고
    • MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition
    • PINKAS, J. and LEDER, P. (2002). MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res 62: 4781-4790.
    • (2002) Cancer Res , vol.62 , pp. 4781-4790
    • Pinkas, J.1    Leder, P.2
  • 31
    • 33845317655 scopus 로고    scopus 로고
    • Illuminating the center: Mechanisms regulating lumen formation and maintenance in mammary morphogenesis
    • REGINATO, M.J. and MUTHUSWAMY, S.K. (2006). Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. J Mammary Gland Biol Neoplasia 11: 205-211.
    • (2006) J Mammary Gland Biol Neoplasia , vol.11 , pp. 205-211
    • Reginato, M.J.1    Muthuswamy, S.K.2
  • 32
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • ROZEN, S. and SKALETSKY, H. (2000). Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.
    • (2000) Methods Mol Biol , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 33
    • 0028834898 scopus 로고
    • Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis
    • SAELMAN, E.U., KEELY, P.J. and SANTORO, S.A. (1995). Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis. J Cell Sci 108: 3531-3540.
    • (1995) J Cell Sci , vol.108 , pp. 3531-3540
    • Saelman, E.U.1    Keely, P.J.2    Santoro, S.A.3
  • 35
    • 0034680834 scopus 로고    scopus 로고
    • Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
    • VADLAMUDI, R.K., ADAM, L., WANG, R.A., MANDAL, M., NGUYEN, D., SAHIN, A., CHERNOFF, J., HUNG, M.C. and KUMAR, R. (2000). Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 275: 36238-36244.
    • (2000) J Biol Chem , vol.275 , pp. 36238-36244
    • Vadlamudi, R.K.1    Adam, L.2    Wang, R.A.3    Mandal, M.4    Nguyen, D.5    Sahin, A.6    Chernoff, J.7    Hung, M.C.8    Kumar, R.9
  • 37
    • 0032217084 scopus 로고    scopus 로고
    • Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
    • WANG, F., WEAVER, V.M., PETERSEN, O.W., LARABELL, C.A., DEDHAR, S., BRIAND, P., LUPU, R. and BISSELL, M.J. (1998). Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci USA 95: 14821-14826.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14821-14826
    • Wang, F.1    Weaver, V.M.2    Petersen, O.W.3    Larabell, C.A.4    Dedhar, S.5    Briand, P.6    Lupu, R.7    Bissell, M.J.8
  • 38
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
    • WEAVER, V.M., PETERSEN, O.W., WANG, F., LARABELL, C.A., BRIAND, P., DAMSKY, C. and BISSELL, M.J. (1997). Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137: 231-245.
    • (1997) J Cell Biol , vol.137 , pp. 231-245
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3    Larabell, C.A.4    Briand, P.5    Damsky, C.6    Bissell, M.J.7
  • 39
  • 40
    • 2142701427 scopus 로고    scopus 로고
    • Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
    • WROBEL, C.N., DEBNATH, J., LIN, E., BEAUSOLEIL, S., ROUSSEL, M.F. and BRUGGE, J.S. (2004). Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol 165: 263-273.
    • (2004) J Cell Biol , vol.165 , pp. 263-273
    • Wrobel, C.N.1    Debnath, J.2    Lin, E.3    Beausoleil, S.4    Roussel, M.F.5    Brugge, J.S.6
  • 41
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • YARDEN, Y. and SLIWKOWSKI, M.X. (2001). Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2: 127-137.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 42
    • 0035990925 scopus 로고    scopus 로고
    • Modulation of protein kinase signaling by protein phosphatases and inhibitors
    • ZHANG, Z.Y., ZHOU, B. and XIE, L. (2002). Modulation of protein kinase signaling by protein phosphatases and inhibitors. Pharmacol Ther 93: 307-317.
    • (2002) Pharmacol Ther , vol.93 , pp. 307-317
    • Zhang, Z.Y.1    Zhou, B.2    Xie, L.3


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