Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction

Genes and Development

Volumn 23, Issue 14, 2009, Pages 1677-1688

  Jechlinger, Martin ^a   Podsypanina, Katrina ^a   Varmus, Harold ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Inducible transgenes; Mammary gland; Oncogene dependence; Primary cells; Residual tumor cells; Three dimensional culture

Indexed keywords

CASPASE 3; DOXYCYCLINE; HOE 33342; ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; CASP3 PROTEIN, MOUSE;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BREAST CARCINOGENESIS; BREAST CELL; BREAST EPITHELIUM; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; METAPHASE; MITOCHONDRION; MITOSIS; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE K RAS; ONCOGENE MYC; POLARIZATION; PRIORITY JOURNAL; REPOLARIZATION; TISSUE CULTURE CELL; TRANSGENE; TRANSGENIC MOUSE; TUMOR RECURRENCE; ANIMAL; CELL DIVISION; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; STEM CELL; TRANSCRIPTION INITIATION; UDDER;

MOUSE MAMMARY TUMOR VIRUS; MUS;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BENZIMIDAZOLES; CASPASE 3; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL SURVIVAL; DOXYCYCLINE; FEMALE; GENE EXPRESSION REGULATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; ONCOGENES; STEM CELLS; TRANSCRIPTIONAL ACTIVATION; TRANSGENES;

EID: 67650588401     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1801809     Document Type: Article

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