Variations on brain microglial gene expression of MMPs, RECK, and TIMPs in inflammatory and non-inflammatory diseases in dogs

Veterinary Immunology and Immunopathology

Volumn 144, Issue 1-2, 2011, Pages 17-26

  Stein, Veronika M ^a   Puff, Christina ^a   Genini, Sem ^b   Contioso, Vanessa Bono ^a   Baumgärtner, Wolfgang ^a,c   Tipold, Andrea ^a,c  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Centre for Systems Neuroscience   (Germany)

Author keywords

Matrix metalloproteinase (MMP); Microglia; MRNA expression; Quantitative real time polymerase chain reaction (qPCR); RECK (reversion inducing cysteine rich protein with Kazal motifs); Tissue inhibitors of matrix metalloproteinases (TIMPs); Zymography

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; REVERSION INDUCING CYSTEINE RICH PROTEIN WITH KAZAL MOTIF; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CELL ISOLATION; CENTRAL NERVOUS SYSTEM; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DIAGNOSTIC IMAGING; DOG; DOWN REGULATION; ENCEPHALITIS; EX VIVO STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETIC VARIABILITY; HISTOPATHOLOGY; INFLAMMATORY DISEASE; LEUKOCYTE; MICROGLIA; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ZYMOGRAPHY;

ANIMALS; BRAIN; BRAIN DISEASES; COLLAGENASES; DOG DISEASES; DOGS; GPI-LINKED PROTEINS; INFLAMMATION; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICROGLIA; REAL-TIME POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASES;

CANIS FAMILIARIS;

EID: 82555191086     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.06.029     Document Type: Article

References (45)

1. Björklund M., Koivunen E. Gelatinase-mediated migration and invasion of cancer cells. Biochim. Biophys. Acta 2005, 1755:37-69.
2. Brew K., Dinakarpandian D., Nagase H. Tissue inhibitors of metalloproteinases: evolution, structures and function. Biochim. Biophys. Acta 2000, 1477:267-283.
3. Bury-Moné S., Nomane Y., Reymond N., Barbet R., Jacquet E., Imbeaud S., Jacq A., Bouloc P. Global analysis of extracytoplasmic stress signaling in Escherichia coli. PLoS Genet. 2009, 5:e1000651.
4. Clements J.M., Cossins J.A., Wells G.M., Corkill D.J., Helfrich K., Wood L.M., Pigott R., Stabler G., Ward G.A., Gearing A.J., Miller K.M. Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor. J. Neuroimmunol. 1997, 74:85-94.
5. Crocker S.J., Frausto R.F., Whitton J.L., Milner R. A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia 2008, 56:1187-1198.
6. Das A., Tan W.L., Smith D.R. Expression of extracellular matrix markers in benign meningiomas. Neuropathology 2003, 23:275-281.
7. Gehrmann J., Kreutzberg G.W. Microglia in experimental neuropathology. Neuroglia 1995, 883-904. Oxford University Press, New York. H. Kettenmann, B.R. Ransom (Eds.).
8. Gijbels K., Masure S., Carton H., Opdenakker G. Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders. J. Neuroimmunol. 1992, 41:29-34.
9. Giulian D. Microglia and disease of the nervous system. Curr. Top. Neurol. 1992, 12:23-24.
10. Gottschall P.E., Deb S. Regulation of matrix metalloproteinase expressions in astrocytes, microglia and neurons. Neuroimmunomodulation 1996, 3:69-75.
11. Graeber M.B., Blakemore W.F., Kreutzberg G.W. Cellular pathology of the central nervous system. Greenfield's Neuropathology 2002, 158-191. Arnold, London. D.I. Graham, P.L. Lantos (Eds.).
12. Gröters S., Alldinger S., Baumgärtner W. Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis. Acta Neuropathologica 2005, 110:369-382.
13. Gurney K.J., Estrada E.Y., Rosenberg G.A. Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation. Neurobiol. Dis. 2006, 23:87-96.
14. Kieseier B.C., Clements J.M., Pischel H.B., Wells G.M., Miller K., Gearing A.J., Hartung H.P. Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barré syndrome. Ann. Neurol. 1998, 43:427-434.
15. Kieseier B.C., Paul R., Koedel U., Seifert T., Clements J.M., Gearing A.J., Pfister H.W., Hartung H.P. Differential expression of matrix metalloproteinases in bacterial meningitis. Brain 1999, 122:1579-1587.
16. Kleiner D.E., Tuuttila A., Tryggvason K., Stetler-Stevenson W.G. Stability analysis of latent and active 72-kDa type IV collagenase: the role of tissue inhibitor of metalloproteinases-2 (TIMP-2). Biochemistry 1993, 32:1583-1592.
17. Kumnok J., Ulrich R., Wewetzer K., Rohn K., Hansmann F., Baumgartner W., Alldinger S. Differential transcription of matrix-metalloproteinase genes in primary mouse astrocytes and microglia infected with Theiler's murine encephalomyelitis virus. J. Neurovirol. 2008, 14:205-217.
18. Lee M.A., Palace J., Stabler G., Ford J., Gearing A., Miller K. Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis. A longitudinal clinical and MRI study. Brain 1999, 122:191-197.
19. Lichtinghagen R., Seifert T., Kracke A., Marckmann S., Wurster U., Heidenreich F. Expression of matrix metalloproteinase-9 and its inhibitors in mononuclear blood cells of patients with multiple sclerosis. J. Neuroimmunol. 1999, 99:19-26.
20. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
21. Lo E.H., Wang X., Cuzner M.L. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J. Neurosci. Res. 2002, 69:1-9.
22. Mandl J.N., Barry A.P., Vanderford T.H., Kozyr N., Chavan R., Klucking S., Barrat F.J., Coffman R.L., Staprans S.I., Feinberg M.B. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nat. Med. 2008, 14:1077-1087.
23. Massova I., Kotra L.P., Fridman R., Mobashery S. Matrix metalloproteinases: structures, evolution, and diversification. FASEB J. 1998, 12:1075-1095.
24. Matrisian L.M. Metalloproteinases and their inhibitors in matrix remodelling. Trends Genet. 1990, 6:121-125.
25. McCawley L.J., Matrisian L.M. Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol. Med. Today 2000, 6:149-156.
26. Miao Q., Baumgärtner W., Failing K., Alldinger S. Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis. Acta Neuropathologica 2003, 106:486-494.
27. Mun-Bryce S., Rosenberg G.A. Gelatinase B modulates selective opening of the blood-brain barrier during inflammation. Am. J. Physiol. 1998, 274:R1203-R1211.
28. Parks W.C., Wilson C.L., López-Boado Y.S. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat. Rev. Immunol. 2004, 4:617-629.
29. Puff C., Krudewig C., Imbschweiler I., Baumgärtner W., Alldinger S. Influence of persistent canine distemper virus infection on expression of RECK, matrix-metalloproteinases and their inhibitors in a canine macrophage/monocytic tumour cell line (DH82). Vet. J. 2009, 182:100-107.
30. Pul R., Kopadze T., Skripuletz T., Voss E.V., Kieseier B.C., Stangel M. Polyclonal immunoglobulins (IVIg) induce expression of MMP-9 in microglia. J. Neuroimmunol. 2009, 217:46-50.
31. Raivich G., Bohatschek M., Kloss C.U.A., Werner A., Jones L.L., Kreutzberg G.W. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res. Rev. 1999, 30:77-105.
32. Rosenberg G.A. Matrix metalloproteinases in neuroinflammation. Glia 2002, 39:279-291.
33. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 2000, 132:365-386.
34. Siddique K., Yanamandra N., Gujrati M., Dinh D., Rao J.S., Olivero W. Expression of matrix metalloproteinases, their inhibitors, and urokinase plasminogen activator in human meningiomas. Int. J. Oncol. 2003, 22:289-294.
35. Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J. Pathol. 2003, 200:448-464.
36. Stein V.M., Baumgärtner W., Kreienbrock L., Zurbriggen A., Vandevelde M., Tipold A. Canine microglial cells: stereotypy in immunophenotype and specificity in function?. Vet. Immunol. Immunopathol. 2006, 113:277-287.
37. Stein V.M., Czub M., Hansen R., Leibold W., Moore P.F., Zurbriggen A., Tipold A. Characterization of canine microglia isolated ex vivo. Vet. Immunol. Immunopathol. 2004, 99:73-85.
38. Stoll G., Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 1999, 58:233-247.
39. Streit W.J., Graeber M.B., Kreutzberg G.W. Functional plasticity of microglia: a review. Glia 1988, 1:301-307.
40. Sternlicht M.D., Werb Z. How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell Dev. Biol. 2001, 17:463-516.
41. Waubant E., Goodkin D.E., Gee L., Bacchetti P., Sloan R., Stewart T., Andersson P.B., Stabler G., Miller K. Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis. Neurology 1999, 53:1397-1401.
42. Wellman M.L., Krakowka S., Jacobs R.M., Kociba G.J. A macrophage-monocyte cell line from a dog with malignant histiocytosis. In Vitro Cell. Dev. Biol. 1998, 24:223-229.
43. Woessner J.F. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 1991, 5:2145-2153.
44. Yong V.W., Krekoski C.A., Forsyth P.A., Bell R., Edwards D.R. Matrix metalloproteinases and diseases of the CNS. Trends Neurosci. 1998, 21:75-80.
45. Yong V.W., Power C., Forsyth P., Edwards D.R. Metalloproteinases in biology and pathology of the nervous system. Nat. Rev. Neurosci. 2001, 2:502-511.