A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo

Clinical Cancer Research

Volumn 17, Issue 23, 2011, Pages 7265-7272

  Banh, Alice ^a   Xiao, Nan ^a   Cao, Hongbin ^a   Chen, Che Hong ^a   Kuo, Peiwen ^a   Krakow, Trevor ^a   Bavan, Brindha ^a   Khong, Brian ^a   Yao, Mike ^a   Ha, Chi ^a   Kaplan, Michael J ^a   Sirjani, Davud ^a   Jensen, Kristin ^b   Kong, Christina S ^b   Mochly Rosen, Daria ^a   Koong, Albert C ^a   Le, Quynh Thu ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 3; BROXURIDINE; CD34 ANTIGEN; COLLAGEN; PILOCARPINE; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

ACINAR CELL; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD34 SELECTION; CELL DIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; DIAGNOSTIC KIT; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY STEM CELL; STEM CELL;

ADULT STEM CELLS; ALDEHYDE DEHYDROGENASE; ALLYL COMPOUNDS; ANIMALS; ANTIGENS, CD34; ANTIGENS, CD44; ANTIGENS, LY; ANTIGENS, THY-1; BENZODIOXOLES; BROMODEOXYURIDINE; ENZYME ACTIVATION; ENZYME ACTIVATORS; HEAD AND NECK NEOPLASMS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-KIT; RNA, MESSENGER; SUBMANDIBULAR GLAND; XEROSTOMIA;

EID: 82555189398     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-0179     Document Type: Article

References (34)

1. Cotrim AP, Sowers AL, Lodde BM, Vitolo JM, Kingman A, Russo A, et al. Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res 2005;11:7564-8. (Pubitemid 41507719)
2. Lombaert IM, Brunsting JF, Wierenga PK, Faber H, Stokman MA, Kok T, et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One 2008;3:e2063.
3. Tran SD, Wang J, Bandyopadhyay BC, Redman RS, Dutra A, Pak E, et al. Primary culture of polarized human salivary epithelial cells for use in developing an artificial salivary gland. Tissue Eng 2005;11:172-81. (Pubitemid 40515185)
4. Lombaert IM, Wierenga PK, Kok T, Kampinga HH, deHaan G, Coppes RP. Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands. Clin Cancer Res 2006;12:1804-12.
5. Lee NY, Le QT. New developments in radiation therapy for head and neck cancer: intensity-modulated radiation therapy and hypoxia targeting. Semin Oncol 2008;35:236-50. (Pubitemid 351787693)
6. Sagowski C, Wenzel S, Metternich FU, Kehrl W. Studies on the radioprotective potency of amifostine on salivary glands of rats during fractionated irradiation: acute and late effects. Eur Arch Otorhinolaryngol 2003;260:42-7. (Pubitemid 36207661)
7. Tatsuishi Y, Hirota M, Kishi T, Adachi M, Fukui T, Mitsudo K, et al. Human salivary gland stem/progenitor cells remain dormant even after irradiation. Int J Mol Med 2009;24:361-6.
8. Murdoch-Kinch CA, Kim HM, Vineberg KA, Ship JA, Eisbruch A. Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 2008;72:373-82.
9. Kam MK, Leung SF, Zee B, Chau RM, Suen JJ, Mo F, et al. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol 2007;25:4873-9. (Pubitemid 350220416)
10. Liu XK, Su Y, Jha N, Hong MH, Mai HQ, Fan W, et al. Submandibular salivary gland transfer for the prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma: 5-year outcomes. Head Neck 2011;33:389-95.
11. Jha N, Seikaly H, Harris J, Williams D, Sultanem K, Hier M, et al. Phase III randomized study: oral pilocarpine versus submandibular salivary gland transfer protocol for the management of radiation-induced xerostomia. Head Neck 2009;31:234-43.
12. Rotter N, Oder J, Schlenke P, Lindner U, Bohrnsen F, Kramer J, et al. Isolation and characterization of adult stem cells from human salivary glands. Stem Cells Dev 2008;17:509-18. (Pubitemid 351948198)
13. Szlavik V, Szabo B, Vicsek T, Barabas J, Bogdan S, Gresz V, et al. Differentiation of primary human submandibular gland cells cultured on basement membrane extract. Tissue Eng Part A 2008;14:1915-26.
14. Jiang F, Qiu Q, Khanna A, Todd NW, Deepak J, Xing L, et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Mol Cancer Res 2009;7:330-8.
15. Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, et al. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009;69:3382-9.
16. Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ, et al. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci U S A 2006;103:11707-12. (Pubitemid 44182515)
17. Moreb JS, Baker HV, Chang LJ, Amaya M, Lopez MC, Ostmark B, et al. ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells. Mol Cancer 2008;7:87.
18. Sreerama L, Sladek NE. Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug-metabolizing enzymes in human breast malignancies. Clin Cancer Res 1997;3:1901-14. (Pubitemid 27505115)
19. Levi BP, Yilmaz OH, Duester G, Morrison SJ. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood 2009;113:1670-80.
20. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 2008;321:1493-5.
21. Lin AL, Johnson DA, Wu Y, Wong G, Ebersole JL, Yeh CK. Measuring short-term gamma-irradiation effects on mouse salivary gland function using a new saliva collection device. Arch Oral Biol 2001;46:1085-9. (Pubitemid 32963996)
22. Kishi T, Takao T, Fujita K, Taniguchi H. Clonal proliferation of multi-potent stem/progenitor cells in the neonatal and adult salivary glands. Biochem Biophys Res Commun 2006;340:544-52. (Pubitemid 43021782)
23. Feng J, van der Zwaag M, Stokman MA, van Os R, Coppes RP. Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiother Oncol 2009;92:466-71.
24. Bullard T, Koek L, Roztocil E, Kingsley PD, Mirels L, Ovitt CE. Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands. Dev Biol 2008;320:72-8.
25. Tucker AS. Salivary gland adaptations: modification of the glands for novel uses. Front Oral Biol 2010;14x:21-31.
26. Hsu LC, Chang WC. Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family. Gene 1996;174:319-22. (Pubitemid 26340815)
27. Moreb JS. Aldehyde dehydrogenase as a marker for stem cells. Curr Stem Cell Res Ther 2008;3:237-46.
28. Storms RW, Trujillo AP, Springer JB, Shah L, Colvin OM, Ludeman SM, et al. Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity. Proc Natl Acad Sci U S A 1999;96:9118-23. (Pubitemid 29374717)
29. Armstrong L, Stojkovic M, Dimmick I, Ahmad S, Stojkovic P, Hole N, et al. Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity. Stem Cells 2004;22:1142-51. (Pubitemid 39636394)
30. Corti S, Locatelli F, Papadimitriou D, Donadoni C, Salani S, Del Bo R, et al. Identification of a primitive brain-derived neural stem cell population based on aldehyde dehydrogenase activity. Stem Cells 2006;24:975-85. (Pubitemid 44464730)
31. Jean E, Laoudj-Chenivesse D, Notarnicola C, Rouger K, Serratrice N, Bonnieu A, et al. Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells. J Cell Mol Med 2011;15:119-33.
32. Zhou P, Hohm S, Olusanya Y, Hess DA, Nolta J. Human progenitor cells with high aldehyde dehydrogenase activity efficiently engraft into damaged liver in a novel model. Hepatology 2009;49:1992-2000.
33. Estes BT, Wu AW, Storms RW, Guilak F. Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells. J Cell Physiol 2006;209:987-95. (Pubitemid 44665721)
34. Hess DA, Craft TP, Wirthlin L, Hohm S, Zhou P, Eades WC, et al. Widespread nonhematopoietic tissue distribution by transplanted human progenitor cells with high aldehyde dehydrogenase activity. Stem Cells 2008;26:611-20.